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Foie Gras SIGNED

Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 Foie Gras project word cloud

Explore the words cloud of the Foie Gras project. It provides you a very rough idea of what is the project "Foie Gras" about.

biosciences    stage    pathogenesis    gut    secondments    answer    societies    scientific    sme    13    training    innovative    citizens    commercialization    complementary    utilize    gras    cohesive    employment    interventions    advancing    network    first    stratification    disruption    economic    esrs    asia    prospects    fatty    skill    hepatic    endowed    disease    excellent    nafld    therapeutic    western    thereby    patient    expertise    cetics    alongside    liver    counterparts    questions    risk    critical    trained    lifestyle    skills    clinical    translational    industrial    creation    carcinoma    burden    unanswered    contributions    workshops    nash    nonalcoholic    outreach    diabetes    enhances    axis    societal    provides    remodelling    hepatocellular    reversing    health    surge    transfer    approaching    foie    diverse    lacking    seahorse    combination    intersection    sectors    alcoholic    organization    bioenergetic    public    combines    steatohepatitis    progression    academic    translation    synergistic    supporting    basic    interdisciplinary    cirrhosis    mediagnost    affiliated   

Project "Foie Gras" data sheet

The following table provides information about the project.

Coordinator
CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO 

Organization address
address: UNIVERSIDADE DE COIMBRA, LARGO DE POMBAL
city: COIMBRA
postcode: 3004 517
website: www.cnbc.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://www.projectfoiegras.eu/
 Total cost 3˙202˙195 €
 EC max contribution 3˙202˙195 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO PT (COIMBRA) coordinator 476˙712.00
2    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 516˙122.00
3    UNIVERSITA DEGLI STUDI DI BARI ALDO MORO IT (BARI) participant 516˙122.00
4    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 262˙875.00
5    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 249˙216.00
6    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 247˙872.00
7    Faculdade de Farmácia da Universidade de Lisboa PT (Lisboa) participant 238˙356.00
8    UNIVERSIDADE DO PORTO PT (PORTO) participant 238˙356.00
9    FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI) CZ (PRAHA 4) participant 232˙422.00
10    INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK PL (WARSZAWA) participant 224˙137.00
11    Associação Protectora dos Diabéticos de Portugal PT (Lisboa) partner 0.00
12    Cetics GmbH DE (Esslingen am Neckar) partner 0.00
13    MEDIAGNOST GESELLSCHAFT FUR FORSCHUNG UND HERSTELLUNG VON DIAGNOSTIKA GMBH DE (REUTLINGEN) partner 0.00
14    SEAHORSE BIOSCIENCE EUROPE APS DK (KOBENHAVN) partner 0.00

Map

 Project objective

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of non-alcoholic fatty liver disease (NAFLD). Its progression to nonalcoholic steatohepatitis (NASH) is a leading risk factor for development of Type 2 diabetes, cirrhosis, and hepatocellular carcinoma. FOIE GRAS is first in supporting a cohesive and synergistic intersection of complementary and interdisciplinary training skills from academic and non-academic partners. FOIE GRAS combines strong scientific expertise with integrated and complementary training in translational research, clinical practice, technology commercialization, and public outreach, the combination of which in targeting NAFLD is lacking in the EU. Industrial partners CETICS, Mediagnost and Seahorse Biosciences provide experience on technology commercialization alongside scientific contributions while the affiliated patient organization will contribute with important training in societal awareness topics. ESRs training will utilize network-wide workshops and secondments to foster translation of basic research to clinical applications and SME creation. This diverse yet integrated skill set enhances the employment prospects of the trained researchers in both academic and non-academic sectors. Researchers will be endowed with excellent basic scientific knowledge and timely technology transfer know-how for developing novel therapeutic approaches for reversing the burden of NAFLD, thereby advancing both health and economic well-being of European citizens and approaching NAFLD research in the EU from its counterparts in the US and Asia.

 Deliverables

List of deliverables.
Supervisory Board of the network Other 2019-05-13 12:07:39
FOIE GRAS public website Websites, patent fillings, videos etc. 2019-05-13 12:07:39

Take a look to the deliverables list in detail:  detailed list of Foie Gras deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Amine Majdi, Lynda Aoudjehane, Vlad Ratziu, Tawhidul Islam, Marta B. Afonso, Filomena Conti, Taïeb Mestiri, Marie Lagouge, Fabienne Foufelle, Florine Ballenghien, Tatiana Ledent, Marthe Moldes, Axelle Cadoret, Laura Fouassier, Jean-Louis Delaunay, Tounsia Aït-Slimane, Gilles Courtois, Bruno Fève, Olivier Scatton, Carina Prip-Buus, Cecília M.P. Rodrigues, Chantal Housset, Jérémie Gautheron
Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease
published pages: , ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.11.008
Journal of Hepatology 2019-12-16
2019 Molina-Molina E, Shanmugam H,Wang DQH, Vergani L, Portincasa P.
Physical Activity is Beneficial for Gallbladder Disease
published pages: 1-4, ISSN: 2435-1210, DOI:
Japanese Journal of Gastroenterology and Hepatology 1(1) 2019-11-22
2019 Malik, Simões, Rosa, Khan, Karkucinska-Wieckowska, Wieckowski
A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease
published pages: 1222, ISSN: 2073-4409, DOI: 10.3390/cells8101222
Cells 8/10 2019-11-14
2019 Getachew Debas Belew, Joao Silva, Joao Rito, Ludgero Tavares, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, Maria Paula Macedo, John G. Jones
Transfer of Glucose Hydrogens via Acetyl-CoA, Malonyl-CoA and NADPH to Fatty Acids during de novo Lipogenesis
published pages: jlr.RA119000354, ISSN: 0022-2275, DOI: 10.1194/jlr.ra119000354
Journal of Lipid Research 2019-10-08
2019 Adriana Fontes, Mireia Alemany-Pagès, Paulo J. Oliveira, João Ramalho-Santos, Hans Zischka, Anabela Marisa Azul
Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease
published pages: 3987, ISSN: 1422-0067, DOI: 10.3390/ijms20163987
International Journal of Molecular Sciences 20/16 2019-10-03
2019 Ivana Jarak, Cristina Barosa, Fatima O. Martins, Joao C. P. Silva, Cristiano Santos, Getachew Debas Belew, Joao Rito, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, John G. Jones
Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate
published pages: 639-644, ISSN: 0740-3194, DOI: 10.1002/mrm.27378
Magnetic Resonance in Medicine 81/1 2019-06-18
2018 Emilio Molina-Molina, Raquel Lunardi Baccetto, David Q-H Wang, Ornella de Bari, Marcin Krawczyk, Piero Portincasa
Exercising the hepatobiliary-gut axis. The impact of physical activity performance
published pages: e12958, ISSN: 0014-2972, DOI: 10.1111/eci.12958
European Journal of Clinical Investigation 2019-06-12
2018 Arnau Panisello-Roselló, Norma Alva, Marta Flores, Alexandre Lopez, Carlos Castro Benítez, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, René Adam, Teresa Carbonell, Joan Roselló-Catafau
Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury
published pages: 2479, ISSN: 1422-0067, DOI: 10.3390/ijms19092479
International Journal of Molecular Sciences 19/9 2019-06-12
2018 Arnau Panisello-Roselló, Norma Alva, Marta Flores, Alexandre Lopez, Carlos Castro Benítez, Emma Folch-Puy, Anabela Rolo, Carlos Palmeira, René Adam, Teresa Carbonell, Joan Roselló-Catafau
Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury
published pages: 2479, ISSN: 1422-0067, DOI: 10.3390/ijms19092479
International Journal of Molecular Sciences 19/9 2019-05-23
2019 Ivana Jarak, Cristina Barosa, Fatima O. Martins, Joao C. P. Silva, Cristiano Santos, Getachew Debas Belew, Joao Rito, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, John G. Jones
Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate
published pages: 639-644, ISSN: 0740-3194, DOI: 10.1002/mrm.27378
Magnetic Resonance in Medicine 81/1 2019-05-23
2019 Martina Theresa Hackl, Clemens Fürnsinn, Christina Maria Schuh, Martin Krssak, Fabrizia Carli, Sara Guerra, Angelika Freudenthaler, Sabina Baumgartner-Parzer, Thomas H. Helbich, Anton Luger, Maximilian Zeyda, Amalia Gastaldelli, Christoph Buettner, Thomas Scherer
Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10684-1
Nature Communications 10/1 2019-08-06
2019 Emilio Molina-Molina, Leonilde Bonfrate, Michele Lorusso, Harshitha Shanmugam, Giuseppe Scaccianoce, Theodore Rokkas, Piero Portincasa
Faster Detection of Helicobacter pylori Infection by 13 C-Urea Breath Test. Comparing Short versus Standard Sampling Time
published pages: 151-161, ISSN: 1841-8724, DOI: 10.15403/jgld-175
Journal of Gastrointestinal and Liver Diseases 28 2019-08-06
2019 Ignazio Grattagliano, Liliana P. Montezinho, Paulo J. Oliveira, Gema Frühbeck, Javier Gómez-Ambrosi, Fabrizio Montecucco, Federico Carbone, Mariusz R. Wieckowski, David Q.-H. Wang, Piero Portincasa
Targeting mitochondria to oppose the progression of nonalcoholic fatty liver disease
published pages: 34-45, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.11.020
Biochemical Pharmacology 160 2019-05-13
2018 Arnau Panisello-Roselló, Joan Roselló-Catafau
Molecular Mechanisms and Pathophysiology of Ischemia-Reperfusion Injury
published pages: 4093, ISSN: 1422-0067, DOI: 10.3390/ijms19124093
International Journal of Molecular Sciences 19/12 2019-05-13
2018 A. Panisello-Rosello, C. Castro-Benítez, A. Lopez, S. Balloji, E. Folch-Puy, R. Adam, J. Roselló-Catafau
Graft Protection Against Cold Ischemia Preservation: An Institute George Lopez 1 and Histidine-tryptophan-ketoglutarate Solution Appraisal
published pages: 714-718, ISSN: 0041-1345, DOI: 10.1016/j.transproceed.2018.02.044
Transplantation Proceedings 50/3 2019-05-13
2018 Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha-Gonçalves, Maria Paula Macedo
Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells
published pages: 1080-1094, ISSN: 2471-254X, DOI: 10.1002/hep4.1225
Hepatology Communications 2/9 2019-05-13
2018 Hu Huang, Seung-Hwan Lee, Inês Sousa-Lima, Sang Soo Kim, Won Min Hwang, Yossi Dagon, Won-Mo Yang, Sungman Cho, Min-Cheol Kang, Ji A. Seo, Munehiko Shibata, Hyunsoo Cho, Getachew Debas Belew, Jinhyuk Bhin, Bhavna N. Desai, Min Jeong Ryu, Minho Shong, Peixin Li, Hua Meng, Byung-Hong Chung, Daehee Hwang, Min Seon Kim, Kyong Soo Park, Maria Paula Macedo, Morris White, John Jones, Young-Bum Kim
Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition
published pages: 5335-5350, ISSN: 0021-9738, DOI: 10.1172/jci63562
Journal of Clinical Investigation 128/12 2019-05-13
2018 Arnau Panisello-Roselló, Alexandre Lopez, Emma Folch-Puy, Teresa Carbonell, Anabela Rolo, Carlos Palmeira, René Adam, Marc Net, Joan Roselló-Catafau
Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
published pages: 2984-2994, ISSN: 1007-9327, DOI: 10.3748/wjg.v24.i27.2984
World Journal of Gastroenterology 24/27 2019-05-13
2019 Ivana Jarak, Cristina Barosa, Fatima O. Martins, Joao C. P. Silva, Cristiano Santos, Getachew Debas Belew, Joao Rito, Ivan Viegas, Jose Teixeira, Paulo J. Oliveira, John G. Jones
Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate
published pages: 639-644, ISSN: 0740-3194, DOI: 10.1002/mrm.27378
Magnetic Resonance in Medicine 81/1 2019-05-13

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