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DismantlingNoise SIGNED

Dissecting the (epi)genetic origins of phenotypic variation and metabolic disease susceptibility

Total Cost €

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EC-Contrib. €

0

Partnership

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 DismantlingNoise project word cloud

Explore the words cloud of the DismantlingNoise project. It provides you a very rough idea of what is the project "DismantlingNoise" about.

billion    prevalence    chief    environment    latter    generates    time    vary    100    epigenome    disease    2030    regulator    map    economic    stable    mice    stochastic    understand    isogenic    phenome    socio    genetic    mapped    completely    fat    emergence    gene    feeding    trigger    variation    body    phenomics    current    obesity    epigenetic    builds    poorly    mutants    weight    plasticity    perfect    mechanisms    chromatin    dozen    series    phenotypic    unprecedented    place    matrix    worldwide    epigenetically    risk    regulatory    dissection    functional    eight    models    day    sensitized    contribution    powerful    framework    epistasis    resolution    interactions    stroke    begin    etiological    heart    regulation    unbiased    bi    developmental    context    first    buffer    catalogue    critical    explanation    examine    c57bl6    layers    estimates    mechanistic    epi    approximately    amplify    molecular    susceptibility    diabetes   

Project "DismantlingNoise" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.ie-freiburg.mpg.de/pospisilik
 Total cost 1˙997˙853 €
 EC max contribution 1˙997˙853 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙997˙853.00

Map

 Project objective

Current estimates place the prevalence of obesity beyond 1 billion by the year 2030. As a critical risk factor for heart disease, diabetes and stroke, obesity represents one of the chief socio-economic challenges of our day. While studies have mapped a genetic framework for understanding obesity, the etiological contribution of several regulatory layers, and in particular epigenetic regulation, remain poorly understood. A perfect example, we know that isogenic C57Bl6/J mice can vary by as much as 100% in body weight upon high fat feeding; currently, we have no mechanistic explanation for the emergence of such phenotypic variation. Here, I propose three aims dedicated towards understanding the (epi)genetic control of phenotypic variation and disease susceptibility. First, we will catalogue epigenome and phenome variation to an unprecedented depth and resolution in the isogenic context. Next, we will examine two completely novel models of epigenetically sensitized bi-stable obesity and thus begin a mechanistic dissection of phenotypic variation. Finally, we will map a series of gene-gene and gene-environment epistasis interactions including eight models of developmental plasticity and approximately a dozen chromatin regulator mutants. The latter epistasis matrix will identify the molecular mechanisms that trigger, amplify and buffer phenotypic variation and stochastic obesity in mice. The functional (epi)phenomics approach is unique. It builds the first unbiased framework against which to understand developmental plasticity and phenotypic variation, and at the same time generates powerful resources for disease researchers worldwide.

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The information about "DISMANTLINGNOISE" are provided by the European Opendata Portal: CORDIS opendata.

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