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CINMAB

Chiral Plasmons in Protein-Nanoparticle Hybrid Materials for Application as Biosensors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CINMAB project word cloud

Explore the words cloud of the CINMAB project. It provides you a very rough idea of what is the project "CINMAB" about.

therapy    mechanism       gold    nps    possessing    assembly    fabricate    nanoparticle    dimensional    utilize    sers    template    helical    electrostatic    patients    transfer    investigations    emphasized    molecules    biosensors    spectroscopic    utilized    interactions    nanomaterials    material    nature    surface    blood    signals    largely    raman    diabetic    crystals    smart    metal    aggregates    delivered    mode    proteins    scattering    covalent    below    detection    crystallographic    hence    enhanced    disassembly    fabrication    function    chiral    phenomena    insulin    conjugates    dissolution    first    nrs    plasmonic    direction    heterojunctions    ultimate    materials    candidates    hybrid    fabricating    silver    form    neurodegenerative    crystal    biological    generate    templates    medication    utilizing    nanoparticles    slow    synthesis    ing    fact    variety    plasmons    supplying    diseases    outlined    nanorods    stream    chirality    protein    efficient   

Project "CINMAB" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE 

Organization address
address: PASEO MIRAMON 182, PARQUE TECNOLOGICO DE SAN SEBASTIAN EDIFICIO EMPRESARIAL C
city: SAN SEBASTIAN
postcode: 20009
website: www.cicbiomagune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.cicbiomagune.es
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-10-20   to  2018-10-19

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE ES (SAN SEBASTIAN) coordinator 170˙121.00

Map

 Project objective

The real challenge in the field of nanomaterials is to fabricate hybrid systems that can function as smart materials in a wide variety of applications. Hybrid systems possessing protein templates can be potential candidates in this direction due to the wide variety of applications possible in biological systems. The project outlined below aims at the synthesis of novel hybrid conjugates based on protein templates and gold/silver nanoparticles (NPs)/nanorods (NRs) as plasmonic materials to generate chiral plasmons. Different proteins will be utilized for the fabrication of two different chiral templates: (i) helical one dimensional aggregates and (ii) chiral crystals. The plasmonic metal NPs/NRs can be introduced on these templates utilizing electrostatic and covalent interactions resulting in chiral plasmons. The mechanism of chirality transfer from the template to NPs/NRs can be studied by the detailed crystallographic investigations of the template, nanoparticle and their heterojunctions. The extent of chirality transfer would depend largely on the nature of the template and hence the project aims at fabricating hybrid systems wherein the transfer of chirality from the template to the plasmonic material is efficient. The hybrid systems can be used for enhancing the spectroscopic signals of molecules in Surface Enhanced Raman Scattering (SERS). Our ultimate goal is to utilize the hybrid chiral systems as biosensors (i) for the detection of assembly and disassembly of proteins as well as (ii) for understanding crystallographic changes in medication. The importance of the first part is emphasized by the fact that the assembly of proteins is the cause for various neurodegenerative diseases and its disassembly can be an effective mode of therapy. On the other hand, the insulin is delivered to diabetic patients in the form of crystals and the slow crystal dissolution is the mode of supplying insulin into the blood stream. The importance of the two biological phenomena m

 Publications

year authors and title journal last update
List of publications.
2018 Jatish Kumar, Luis M. Liz-Marzán
Recent Advances in Chiral Plasmonics – Towards Biomedical Applications
published pages: , ISSN: 0009-2673, DOI: 10.1246/bcsj.20180236
Bulletin of the Chemical Society of Japan 2019-05-13
2018 Jatish Kumar, Hasier Eraña, Elena López-Martínez, Nathalie Claes, Víctor F. Martín, Diego M. Solís, Sara Bals, Aitziber L. Cortajarena, Joaquín Castilla, Luis M. Liz-Marzán
Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality
published pages: 3225-3230, ISSN: 0027-8424, DOI: 10.1073/PNAS.1721690115
Proceedings of the National Academy of Sciences 115/13 2019-05-13
2018 Xiaoling Wu, Changlong Hao, Jatish Kumar, Hua Kuang, Nicholas A. Kotov, Luis M. Liz-Marzán, Chuanlai Xu
Environmentally responsive plasmonic nanoassemblies for biosensing
published pages: 4677-4696, ISSN: 0306-0012, DOI: 10.1039/c7cs00894e
Chemical Society Reviews 47/13 2019-05-13
2016 Jatish Kumar, K. George Thomas, Luis M. Liz-Marzán
Nanoscale chirality in metal and semiconductor nanoparticles
published pages: 12555-12569, ISSN: 1359-7345, DOI: 10.1039/C6CC05613J
Chemical Communications 52/85 2019-05-13

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The information about "CINMAB" are provided by the European Opendata Portal: CORDIS opendata.

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