DeMMYR SIGNED
Decoding the molecular mechanisms driving host adaptation of yellow rust on cereal crops and grasses
Total Cost €
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Project "DeMMYR" data sheet
The following table provides information about the project.
| Coordinator |
JOHN INNES CENTRE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙714˙779 € |
| EC max contribution | 1˙714˙779 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-03-01 to 2022-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | JOHN INNES CENTRE | UK (NORWICH) | coordinator | 1˙714˙779.00 |
Map
Project objective
Yellow rust (YR) disease is a major threat to cereal crops and grasses worldwide, causing significant losses to the global wheat harvest each year. The long-term aim of this research is to develop new varieties of wheat with enhanced resistance to YR. To do this, it is essential to understand host specificity - the ability of the pathogen to specialize on particular grass hosts, coupled with the ability of the host to resist infection by different strains of YR.
I recently pioneered a field-based 'pathogenomics' approach to enable a comprehensive evaluation of the genetic diversity of YR. This new method provides unparalleled resolution of the pathogen population that can identify gene families associated with the ability to cause disease on all the major hosts of YR in Europe, namely wheat barley, rye, triticale and cocksfoot grass. Using this approach, I previously uncovered a genetically distinct population of YR on triticale and showed that these isolates contained gene clusters that were specifically expressed in all isolates identified on triticale and had no or negligible levels of expression in all wheat YR isolates.
In this ERC project, I will use the pathogenomics approach to collect an extensive dataset of YR on all its major hosts, aiming to characterise genomic regions and the genes they encode to understand the underlying regulatory mechanisms that drive host specialization and adaptation. I will then assess changes at the transcriptomic level in closely related host-specialized YR races to provide insights into how pathogens adapt to new hosts. In parallel, I will identify host targets of effectors from YR to resolve the underlying molecular processes that are targeted by the pathogen to enable successful host-specific colonization. I will then disrupt the function of these host targets using precision genome editing to determine their contribution to YR pathogenicity and reveal novel susceptibility genes that are essential for pathogen progression.
Deliverables
| Data management plan | Open Research Data Pilot | 2019-05-31 11:58:51 |
Take a look to the deliverables list in detail: detailed list of DeMMYR deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Diane G. O. Saunders, Zacharias A. Pretorius, Mogens S. Hovmøller Tackling the re-emergence of wheat stem rust in Western Europe published pages: , ISSN: 2399-3642, DOI: 10.1038/s42003-019-0294-9 |
Communications Biology 2/1 | 2019-10-29 |
| 2019 |
M. Carvajal-Yepes, K. Cardwell, A. Nelson, K. A. Garrett, B. Giovani, D. G. O. Saunders, S. Kamoun, J. P. Legg, V. Verdier, J. Lessel, R. A. Neher, R. Day, P. Pardey, M. L. Gullino, A. R. Records, B. Bextine, J. E. Leach, S. Staiger, J. Tohme A global surveillance system for crop diseases published pages: 1237-1239, ISSN: 0036-8075, DOI: 10.1126/science.aaw1572 |
Science 364/6447 | 2019-10-29 |
| 2019 |
Willem H.P. Boshoff, Botma Visser, Clare Lewis, Thomas Michael Adams, Diane Saunders, Tarekegn Terefe, Tegwe Soko, Nyasha Chuiraise, Zacharias A. Pretorius First Report of Puccinia striiformis f. sp. tritici , Causing Stripe Rust of Wheat, in Zimbabwe published pages: , ISSN: 0191-2917, DOI: 10.1094/pdis-07-19-1395-pdn |
Plant Disease | 2019-10-29 |
| 2017 |
Vanessa Bueno-Sancho, Antoine Persoons, Amelia Hubbard, Luis Enrique Cabrera-Quio, Clare M Lewis, Pilar Corredor-Moreno, Daniel C E Bunting, Sajid Ali, Soonie Chng, David P Hodson, Ricardo Madariaga Burrows, Rosie Bryson, Jane Thomas, Sarah Holdgate, Diane G O Saunders Pathogenomic Analysis of Wheat Yellow Rust Lineages Detects Seasonal Variation and Host Specificity published pages: 3282-3296, ISSN: 1759-6653, DOI: 10.1093/gbe/evx241 |
Genome Biology and Evolution 9/12 | 2019-10-29 |
| 2019 |
E.S. Orton, C.M. Lewis, P.E. Davey, G.V. Radhakrishnan, D.G.O. Saunders Stem rust ( Puccina graminis ) identified on spring barley in the UK adjacent to infected Berberis vulgaris published pages: 11, ISSN: 2044-0588, DOI: 10.5197/j.2044-0588.2019.040.011 |
New Disease Reports 40 | 2019-10-29 |
| 2019 |
Pilar Corredorâ€Moreno, Diane G. O. Saunders Expecting the unexpected: factors influencing the emergence of fungal and oomycete plant pathogens published pages: , ISSN: 0028-646X, DOI: 10.1111/nph.16007 |
New Phytologist | 2019-10-29 |
| 2019 |
Guru V. Radhakrishnan, Nicola M. Cook, Vanessa Bueno-Sancho, Clare M. Lewis, Antoine Persoons, Abel Debebe Mitiku, Matthew Heaton, Phoebe E. Davey, Bekele Abeyo, Yoseph Alemayehu, Ayele Badebo, Marla Barnett, Ruth Bryant, Jeron Chatelain, Xianming Chen, Suomeng Dong, Tina Henriksson, Sarah Holdgate, Annemarie F. Justesen, Jay Kalous, Zhensheng Kang, Szymon Laczny, Jean-Paul Legoff, Driecus Lesch, MARPLE, a point-of-care, strain-level disease diagnostics and surveillance tool for complex fungal pathogens published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-019-0684-y |
BMC Biology 17/1 | 2019-10-29 |
| 2018 |
Clare M. Lewis, Antoine Persoons, Daniel P. Bebber, Rose N. Kigathi, Jens Maintz, Kim Findlay, Vanessa Bueno-Sancho, Pilar Corredor-Moreno, Sophie A. Harrington, Ngonidzashe Kangara, Anna Berlin, Richard GarcÃa, Silvia E. Germán, Alena Hanzalová, David P. Hodson, Mogens S. Hovmøller, Julio Huerta-Espino, Muhammed Imtiaz, Javed Iqbal Mirza, Annemarie F. Justesen, Rients E. Niks, Ali Omrani, Meh Potential for re-emergence of wheat stem rust in the United Kingdom published pages: , ISSN: 2399-3642, DOI: 10.1038/s42003-018-0013-y |
Communications Biology 1/1 | 2019-10-08 |
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