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Risk assessment of plaque rupture and future cardiovascular events (CVENT) by multi-spectral photoacoustic imaging

Total Cost €


EC-Contrib. €






Project "CVENT" data sheet

The following table provides information about the project.


Organization address
address: PHILIPSWEG 1
postcode: 6227AJ
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 4˙697˙377 €
 EC max contribution 4˙260˙790 € (91%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2016-1
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2020-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ESAOTE EUROPE B.V. NL (MAASTRICHT) coordinator 840˙000.00
2    LUMIBIRD FR (LANNION) participant 865˙000.00
4    UNIVERSITEIT TWENTE NL (ENSCHEDE) participant 413˙038.00
5    RUHR-UNIVERSITAET BOCHUM DE (BOCHUM) participant 399˙000.00
6    UNIVERSITE DE PARIS FR (PARIS) participant 399˙000.00
7    BRIGHTLOOP SAS FR (PARIS) participant 299˙916.00
8    SILIOS TECHNOLOGIES SA FR (Peynier) participant 265˙656.00
9    TP21 GMBH DE (BERLIN) participant 223˙750.00
10    UNIVERSITAET BERN CH (BERN) participant 0.00


 Project objective

Cardiovascular disease (CVD), more specifically, vulnerable plaque rupture, remains the major cause of death for people at middle age. The CVENT consortium will revolutionize screening, diagnosis and monitoring of CVD by means of a compact photoacoustic imaging (PAI) system for vulnerable plaque imaging. In the carotid arteries feeding the brain, vulnerable plaque rupture initiates cerebrovascular ischemic attacks. The state-of-the-art decision-making approach for a high-risk surgical intervention to avoid plaque rupture is based on stenosis severity alone, measured with ultrasound (US) imaging. However, this does not distinguish between vulnerable (rupture-prone) and stable (harmless) plaques, leading to severe overtreatment. Consequently, there is a worldwide unmet and urgent clinical need for functional information to enable in-depth diagnosis of carotid plaque vulnerability, avoiding cardiovascular events (CVENT) and reducing overtreatment risk. The objective of the CVENT consortium is the development of a portable multimodal and multiwavelength PAI system with a 3 cm imaging depth, for diagnosis and monitoring of carotid plaque vulnerability. The combination of high optical contrast of PAI and the high resolution of US will be used to identify plaque vulnerability markers, typically lipid pools and intra-plaque haemorrhage. Improved diagnosis of carotid plaque vulnerability will lead to a significant reduction in CVD-related disability and mortality. Simultaneously, by stratifying patients into high and low risk groups, overtreatment is reduced, leading to better allocation of healthcare funds. The CVENT consortium unites leading research groups, clinicians, industrial partners, and their expertise on R&D and a focus on exploitation, creating a breakthrough in carotid plaque vulnerability diagnosis. CVENT will bring together leading experts in the field of CVD, functional US imaging and PAI, introducing clinically applied PAI into the vascular medical arena.


List of deliverables.
Public website and communication kit Websites, patent fillings, videos etc. 2020-02-19 17:21:36

Take a look to the deliverables list in detail:  detailed list of CVENT deliverables.


year authors and title journal last update
List of publications.
2017 Pim J. van den Berg, Khalid Daoudi, Hein J. Bernelot Moens, Wiendelt Steenbergen
Feasibility of photoacoustic/ultrasound imaging of synovitis in finger joints using a point-of-care system
published pages: 8-14, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2017.08.002
Photoacoustics 8 2020-02-19
2018 M. Umit Arabul, H. Maarten Heres, Marcel C. M. Rutten, Marc R. H. M. van Sambeek, Frans N. van de Vosse, Richard G. P. Lopata
Investigation on the Effect of Spatial Compounding on Photoacoustic Images of Carotid Plaques in the In Vivo Available Rotational Range
published pages: 440-447, ISSN: 0885-3010, DOI: 10.1109/TUFFC.2018.2792903
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 65/3 2020-02-19
2017 Mithun Kuniyil Ajith Singh, Michael Jaeger, Martin Frenz, Wiendelt Steenbergen
Photoacoustic reflection artifact reduction using photoacoustic-guided focused ultrasound: comparison between plane-wave and element-by-element synthetic backpropagation approach
published pages: 2245, ISSN: 2156-7085, DOI: 10.1364/BOE.8.002245
Biomedical Optics Express 8/4 2020-02-19

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The information about "CVENT" are provided by the European Opendata Portal: CORDIS opendata.

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