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Sweet Theranostics in Bitter Infections - Seek and Destroy

Total Cost €


EC-Contrib. €






 SWEETBULLETS project word cloud

Explore the words cloud of the SWEETBULLETS project. It provides you a very rough idea of what is the project "SWEETBULLETS" about.

spp    contact    employing    negative    ligand    vitro    empty    resistant    extracellular    wp2    bacterial    manufacturing    covalent    conjugates    packages    noncovalent    site    pipeline    carbohydrate    pace    infection    drugs    linker    nosocomially    theranostics    boost    lectindirecting    gram    appropriate    efficacy    extendable    wp3    optimization    conjugation    smart    biofilm    sweet    global    potency    acting    treatments    treatment    vivo    chronic    deleterious    pathogens    bacteria    tissue    fight    imaging    exposed    alarmingly    appearance    linkers    therapy    cystic    proof    directed    resistances    probes    charging    anti    pathogenic    cleavable    relief    sweetbullets    gap    demanding    overcome    fibrosis    threat    infections    cellular    antibiotics    resistance    klebsiella    carriers    intracellularly    nano    protective    aeruginosa    cargo    drug    linking    inhibitor    clinically    bactericidal    eskape    ligands    noninvasive    release    lectin    mechanism    successful    infected    envelope    proteins    pathogen    enzymes    highest    groups    surface    ing    patients    binding    pseudomonas    efficiency    wp1    fundamentally   

Project "SWEETBULLETS" data sheet

The following table provides information about the project.


Organization address
postcode: 38124

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙551 €
 EC max contribution 1˙499˙551 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2022-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Bacterial infections are now a global threat demanding novel treatments due to the appearance of resistances against antibiotics at a high pace. The ESKAPE pathogens are those with highest importance in the EU and chronic infections due to biofilm formation are a particular task. Noninvasive pathogen-specific imaging of the infected tissue is not clinically available. Its successful implementation will enable the choice of appropriate therapy and boost efficacy. Furthermore, Gram-negative bacteria have a highly protective cellular envelope as an important resistance mechanism for drugs acting intracellularly, resulting in an alarmingly empty drug-pipeline. To overcome this gap, I will establish Lectin-directed Theranostics targeting pathogens via their extracellular carbohydrate-binding proteins at the site of infection for specific imaging and treatment. This will be implemented for the highly resistant ESKAPE pathogen Pseudomonas aeruginosa through 3 different work packages. WP1 Sweet Imaging: Design & conjugation of lectin-directed ligands to imaging probes, Optimization of ligand/linker, in vivo proof-of-concept imaging study. WP2 Sweet Targeting: Delivery of antibiotics to the infection through covalent linking of lectindirecting groups. Employing different antibiotics, assessment of bactericidal potency and targeting efficiency. Manufacturing of nano-carriers with surface exposed lectin-directed ligands, noncovalent charging with antibiotics. In vitro and in vivo targeting. WP3 Sweet SMART Targeting: Conjugates as SMART drugs: specific release of anti-biofilm lectin inhibitor and drug cargo upon contact with pathogen, development of linkers cleavable by pathogenic enzymes. SWEETBULLETS will establish fundamentally novel lectin-directed theranostics to fight these deleterious infections and provide relief to nosocomially infected and cystic fibrosis patients. It is rapidly extendable towards other ESKAPE pathogens, e.g. Klebsiella spp..


year authors and title journal last update
List of publications.
2019 Roman Sommer, Katharina Rox, Stefanie Wagner, Dirk Hauck, Sarah S. Henrikus, Shelby Newsad, Tatjana Arnold, Thomas Ryckmans, Mark Brönstrup, Anne Imberty, Annabelle Varrot, Rolf W. Hartmann, Alexander Titz
Anti-biofilm Agents against Pseudomonas aeruginosa : A Structure–Activity Relationship Study of C -Glycosidic LecB Inhibitors
published pages: 9201-9216, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01120
Journal of Medicinal Chemistry 62/20 2020-04-24
2017 Stefanie Wagner, Dirk Hauck, Michael Hoffmann, Roman Sommer, Ines Joachim, Rolf Müller, Anne Imberty, Annabelle Varrot, Alexander Titz
Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging
published pages: 16559-16564, ISSN: 1433-7851, DOI: 10.1002/anie.201709368
Angewandte Chemie International Edition 56/52 2019-04-03

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