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VGAP

The Viral Genome Associated Proteome

Total Cost €

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EC-Contrib. €

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Partnership

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Project "VGAP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITATSKLINIKUM ERLANGEN 

Organization address
address: MAXIMILIANSPLATZ 2
city: ERLANGEN
postcode: 91054
website: www.uk-erlangen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.virologie.uk-erlangen.de/en/research/research-groups/research-group-of-a-ensser/vgap/
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2019-07-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITATSKLINIKUM ERLANGEN DE (ERLANGEN) coordinator 171˙460.00

Map

 Project objective

The aim of this study is to analyze the comprehensive proteome associated with viral DNA. This systems biology approach that will combine functional proteomics and genomics has the name Viral Genome Associated Proteome (VGAP). It is based on a modification and refinement of the Hybridization Capture of Chromatin Associated Proteins for Proteomics (HyCCAPP) technology. All proteins associated with viral DNA, initially using Herpes simplex virus for proof of concept, will be cross-linked by paraformaldehyde treatment, the viral DNA will be selectively precipitated, and all proteins associated with the viral genome will be analyzed by mass spectrometry. The results will reveal all cellular and viral proteins that physically interact with the viral genome at a certain time and that are involved among others in regulation of viral genome structure, viral gene expression, DNA repair and cellular intrinsic immunity. The development of VGAP, a new method for the specific analysis of the viral genome-associated proteome will provide a new tool for the research of DNA viruses. In theory VGAP should be applicable to all DNA viruses, and we think it will be possible to analyze proteins associated with the DNA of all DNA viruses, so the entire field of virology should profit from the establishment of viral HyCCAPP. DNA viruses include important human pathogens like herpesviruses, human papillomaviruses and adenoviruses. A plethora of novel viral DNA-protein interactions will be discovered that will spark new research projects and can serve as new targets for antiviral therapy and vaccination strategies. Although beyond the scope of this proposal, so far unknown cellular proteins that are needed for efficient viral replication can be used for screening of small molecule libraries and novel small molecule inhibitors identified for antiviral therapy.

 Publications

year authors and title journal last update
List of publications.
2019 Florian Full, Armin Ensser
Early Nuclear Events after Herpesviral Infection
published pages: 1408, ISSN: 2077-0383, DOI: 10.3390/jcm8091408
Journal of Clinical Medicine 8/9 2020-01-29
2017 Florian Full, Alexander Hahn, Anna Großkopf, Armin Ensser
Gammaherpesviral Tegument Proteins, PML-Nuclear Bodies and the Ubiquitin-Proteasome System
published pages: 308, ISSN: 1999-4915, DOI: 10.3390/v9100308
Viruses 9/10 2020-01-29

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The information about "VGAP" are provided by the European Opendata Portal: CORDIS opendata.

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