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BispecificsThatClick SIGNED

Combinatorial Antibody Synthesis for the Discovery of New Anti-Tumour Immunomodulators

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BispecificsThatClick project word cloud

Explore the words cloud of the BispecificsThatClick project. It provides you a very rough idea of what is the project "BispecificsThatClick" about.

antigen    tissues    condensation    efficacy    cell    medicine    monoclonal    acceleration    lack    inefficiency    carcinogenic    library    antigens    lot    harnessing    combination    diels    linear    selectively    bsabs    herein    identification    fight    content    substrates    tagged    antibodies    methodology    platform    modern    community    therapeutic    consist    trigger    responsible    ligation    constructs    cells    led    cancer    specificities    tumour    select    tested    modality    of    anticancer    lie    extense    immunondulatory    significantly    inverse    combinations    mode    assembled    demand    kill    scientific    mabs    immunology    speed    strategies    classic    synthesis    bispecific    efficiency    simultaneously    action    binding    tedious    treatment    tools    electron    bioorthogonal    slow    alder    tag    treatments    malignant    serve    scaffold    anti    reactions    site    bind    imaging    healthy    linkers    immune    throughput   

Project "BispecificsThatClick" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

Map

 Project objective

Cancer represents one of the major challenges for modern medicine as we still lack tools to selectively target malignant over healthy tissues. The main issues with state of the art anti-cancer treatments lie on their inefficiency and their associated side-effects. Improving this treatments has focused a lot of attention of the scientific community and has led to the development of new strategies. Harnessing our own immune system to fight malignant cells is one of the strategies with promising potential to improve cancer treatments, although challenges still remain. An emerging therapeutic modality to trigger our immune system against carcinogenic tissues are bispecific antibodies (bsAbs). bsAbs are the combination of two antigen binding specificities on a common scaffold. The potential of these constructs to bind to two antigens can be used to simultaneously target cancer cells and the immune cell which will effectively kill it. The problem of bsAbs is their slow and tedious production process, which is responsible for their linear development. Herein we propose a methodology to speed up and improve the efficiency of their production. Our approach will consist in using novel site-specific bioorthogonal ligation reactions to tag monoclonal antibodies (mAbs) with linkers that will serve as substrates for an inverse electron demand Diels Alder condensation. By condensation of different combinations of tagged mAbs a library of bsAbs will be assembled. The immunondulatory properties of the bsAbs will be tested in high throughput using a high content imaging platform. We will be able to select potential bsAbs for anticancer treatment from our extense library which will study in more depth using classic immunology methods to determine their mode of action and their anti tumour efficacy. The acceleration of both the synthesis and identification of relevant bsAbs for anticancer treatments would significantly increase the presence and value of this technology.

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The information about "BISPECIFICSTHATCLICK" are provided by the European Opendata Portal: CORDIS opendata.

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