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BispecificsThatClick SIGNED

Combinatorial Antibody Synthesis for the Discovery of New Anti-Tumour Immunomodulators

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BispecificsThatClick project word cloud

Explore the words cloud of the BispecificsThatClick project. It provides you a very rough idea of what is the project "BispecificsThatClick" about.

speed    carcinogenic    of    cells    community    therapeutic    malignant    scaffold    modality    combination    antigens    methodology    combinations    acceleration    imaging    throughput    demand    trigger    significantly    scientific    library    tagged    assembled    immunology    harnessing    diels    serve    tools    bispecific    ligation    extense    immunondulatory    simultaneously    specificities    bsabs    tedious    monoclonal    efficiency    lie    selectively    consist    medicine    tumour    electron    substrates    lot    anticancer    antibodies    content    binding    tested    alder    mode    classic    reactions    condensation    immune    linear    healthy    strategies    platform    action    kill    inefficiency    linkers    inverse    treatment    cancer    tag    select    constructs    treatments    responsible    site    tissues    anti    herein    cell    antigen    lack    fight    synthesis    identification    bind    led    bioorthogonal    mabs    modern    efficacy    slow   

Project "BispecificsThatClick" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-06-03   to  2021-06-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 212˙933.00

Map

 Project objective

Cancer represents one of the major challenges for modern medicine as we still lack tools to selectively target malignant over healthy tissues. The main issues with state of the art anti-cancer treatments lie on their inefficiency and their associated side-effects. Improving this treatments has focused a lot of attention of the scientific community and has led to the development of new strategies. Harnessing our own immune system to fight malignant cells is one of the strategies with promising potential to improve cancer treatments, although challenges still remain. An emerging therapeutic modality to trigger our immune system against carcinogenic tissues are bispecific antibodies (bsAbs). bsAbs are the combination of two antigen binding specificities on a common scaffold. The potential of these constructs to bind to two antigens can be used to simultaneously target cancer cells and the immune cell which will effectively kill it. The problem of bsAbs is their slow and tedious production process, which is responsible for their linear development. Herein we propose a methodology to speed up and improve the efficiency of their production. Our approach will consist in using novel site-specific bioorthogonal ligation reactions to tag monoclonal antibodies (mAbs) with linkers that will serve as substrates for an inverse electron demand Diels Alder condensation. By condensation of different combinations of tagged mAbs a library of bsAbs will be assembled. The immunondulatory properties of the bsAbs will be tested in high throughput using a high content imaging platform. We will be able to select potential bsAbs for anticancer treatment from our extense library which will study in more depth using classic immunology methods to determine their mode of action and their anti tumour efficacy. The acceleration of both the synthesis and identification of relevant bsAbs for anticancer treatments would significantly increase the presence and value of this technology.

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The information about "BISPECIFICSTHATCLICK" are provided by the European Opendata Portal: CORDIS opendata.

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