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ANATOMY-FOUND

Novel Imaging of the heart for new structural and metabolic diagnosis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ANATOMY-FOUND" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 200˙194.00

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 Project objective

Each year cardiovascular disease (CVD) causes over 4 million deaths in Europe. Predictions suggest that 80% of premature heart disease and stroke is preventable, but ~20% of CVDs are misdiagnosed, and in elderly patients up to 60% of CVDs remain undiagnosed. We need to develop new technologies and strategies for early and accurate diagnosis of the biggest killer in western society.

Currently, diagnosis of CVD is based on assessment of macro-anatomy, whole heart function, and whole body metabolic markers. Early CVD processes begin in heart cells, before evolving to the ’macro’ pathology recognisable by traditional techniques. Clinicians desire a non-invasive technique that can provide high-resolution 3D micro-anatomy, and organ specific regional metabolic assessment. However the intricate micro-anatomy of the heart and its dynamic relationship with cardiac function is still fiercely debated.

To elucidate the true micro-anatomy of the heart, and understand its correlation with both pump- and metabolic function in health and disease, I will investigate the following questions: 1)What is the true micro-anatomy of the heart, and how is it remodelled in disease? 2)What is the role of 3D micro-anatomy in 4D pump function? 3)Does micro-anatomical remodelling correlate with regional changes in metabolism?

Using novel state-of-the-art non-invasive 3D and 4D ex-vivo and in-vivo imaging methodologies, I will answer these questions. We will finally understand the micro-anatomy of the heart in 3D, and its relationship with cardiac contraction and metabolism in disease. I hypothesise detecting and correlating novel morphological and metabolic changes upstream of the macro-anatomical and non-specific metabolic changes identifiable by traditional techniques, will offer the foundation for a step-wise change in diagnosis of CVD.

Working with world-renowned researchers, I will develop interdisciplinary skills in functional cardiac imaging to support a productive career in academia.

 Publications

year authors and title journal last update
List of publications.
2017 Paul P Lunkenheimer, Peter Niederer, Robert S Stephenson, Klaus Redmann, Randas V Batista, Morten Smerup, Robert H Anderson
What is the clinical significance of ventricular mural antagonism?
published pages: , ISSN: 1010-7940, DOI: 10.1093/ejcts/ezx382
European Journal of Cardio-Thoracic Surgery 2019-08-30
2017 David H. MacIver, Robert S. Stephenson, Bjarke Jensen, Peter Agger, Damián Sánchez-Quintana, Jonathan C. Jarvis, John B. Partridge, Robert H. Anderson
The end of the unique myocardial band: Part I. Anatomical considerations
published pages: , ISSN: 1010-7940, DOI: 10.1093/ejcts/ezx290
European Journal of Cardio-Thoracic Surgery 2019-08-30
2017 David H. MacIver, John B. Partridge, Peter Agger, Robert S. Stephenson, Bastiaan J.D. Boukens, Camilla Omann, Jonathan C. Jarvis, Henggui Zhang
The end of the unique myocardial band: Part II. Clinical and functional considerations
published pages: , ISSN: 1010-7940, DOI: 10.1093/ejcts/ezx335
European Journal of Cardio-Thoracic Surgery 2019-08-30
2018 Robert Stephenson, Peter Agger, Camilla Omann, Damian Sanchez-Quintana, Jonathan Jarvis, Robert Anderson
Resolving the True Ventricular Mural Architecture
published pages: 34, ISSN: 2308-3425, DOI: 10.3390/jcdd5020034
Journal of Cardiovascular Development and Disease 5/2 2019-08-30
2018 Robert S. Stephenson1, Jack Rowley-Nobel, Caroline B. Jones, Rafael Guerrero, Tristan Lowe, Jichao Zhao, Henggui Zhang and Jonathan C. Jarvis
Morphological Substrates for Atrial Arrhythmogenesis in a Heart With Atrioventricular Septal Defect
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01071
Frontiers in Physiology 9:1071 2019-08-30

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