Explore the words cloud of the Mushroomics project. It provides you a very rough idea of what is the project "Mushroomics" about.
The following table provides information about the project.
|Coordinator Country||Netherlands [NL]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
Take a look of project's partnership.
|1||UNIVERSITEIT UTRECHT||NL (UTRECHT)||coordinator||1˙500˙000.00|
Mushrooms are the sexual reproductive structures of basidiomycetes. Much remains to be learned about the molecular regulation of mushroom development. Only a few genes have been implicated in this process, but their exact function remains unknown. Schizophyllum commune is a model system for mushroom-forming fungi. It was recently shown that this species shows the highest intraspecies DNA variability in eukaryotes with 150 SNPs per 1000 base pairs, yet they can still reproduce sexually. This hypervariabity is also illustrated by variability in the response to environmental factors that initiate mushroom development and by the differences in morphology within this species. I propose a functional genomics approach to elucidate the molecular genetics of mushroom development. We have a collection of 100 S. commune strains sampled world-wide. I propose to leverage the extraordinary diversity among these strains. I will identify genes that explain differences in mushroom morphology and in responses to environmental stimuli such as light and CO2. The genes/alleles responsible for these phenotypes will by mapped by genome sequencing followed by bulk segregant analysis. Transcription factors (TFs) are expected to play an important role in regulation of mushroom development. Therefore I propose to systematically study TF function by generating a knock-down collection of all predicted 313 TFs. The phenotypes of the resulting strains will be analyzed and target genes of TFs will be identified by RNA-Seq and ChIP-Seq. The genes identified by these strategies will subsequently be analyzed to determine their function. My initial results demonstrate the feasibility of this approach. The availability of the strain collection, the available molecular toolbox, and my strong expertise both in genomics and molecular biology of mushroom development will enable me to take a huge step forward in our understanding of mushroom development.
|year||authors and title||journal||last update|
Krisztina KrizsÃ¡n, Ã‰va AlmÃ¡si, Zsolt MerÃ©nyi, Neha Sahu, MÃ¡tÃ© VirÃ¡gh, TamÃ¡s KÃ³szÃ³, Stephen Mondo, Brigitta Kiss, BalÃ¡zs BÃ¡lint, Ursula KÃ¼es, Kerrie Barry, Judit Cseklye, Botond HegedÃ¼s, Bernard Henrissat, Jenifer Johnson, Anna Lipzen, Robin A. Ohm, IstvÃ¡n Nagy, Jasmyn Pangilinan, Juying Yan, Yi Xiong, Igor V. Grigoriev, David S. Hibbett, LÃ¡szlÃ³ G. Nagy
Transcriptomic atlas of mushroom development reveals conserved genes behind complex multicellularity in fungi
published pages: 7409-7418, ISSN: 0027-8424, DOI: 10.1073/pnas.1817822116
|Proceedings of the National Academy of Sciences 116/15||2019-11-08|
Peter Jan Vonk, Natalia Escobar, Han A. B. WÃ¶sten, Luis G. Lugones, Robin A. Ohm
High-throughput targeted gene deletion in the model mushroom Schizophyllum commune using pre-assembled Cas9 ribonucleoproteins
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-44133-2
|Scientific Reports 9/1||2019-11-08|
Peter Jan Vonk, Robin A. Ohm
The role of homeodomain transcription factors in fungal development
published pages: , ISSN: 1749-4613, DOI: 10.1016/j.fbr.2018.04.002
|Fungal Biology Reviews||2019-06-13|
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