SZ_TEST SIGNED
Towards Early Molecular Diagnostics of Schizophrenia
Total Cost €
0EC-Contrib. €
0Partnership
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0SZ_TEST project word cloud
Explore the words cloud of the SZ_TEST project. It provides you a very rough idea of what is the project "SZ_TEST" about.
Project "SZ_TEST" data sheet
The following table provides information about the project.
| Coordinator |
PROTOBIOS OU
Organization address contact info |
| Coordinator Country | Estonia [EE] |
| Project website | https://sztest.eu/ |
| Total cost | 990˙000 € |
| EC max contribution | 990˙000 € (100%) |
| Programme |
1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge) |
| Code Call | H2020-MSCA-RISE-2016 |
| Funding Scheme | MSCA-RISE |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | PROTOBIOS OU | EE (TALLINN) | coordinator | 414˙000.00 |
| 2 | HELSINGIN YLIOPISTO | FI (HELSINGIN YLIOPISTO) | participant | 139˙500.00 |
| 3 | SYSTASY BIOSCIENCE GMBH | DE (MUNCHEN) | participant | 103˙500.00 |
| 4 | OU QURETEC | EE (TARTU) | participant | 85˙500.00 |
| 5 | KING'S COLLEGE LONDON | UK (LONDON) | participant | 76˙500.00 |
| 6 | LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN | DE (MUENCHEN) | participant | 58˙500.00 |
| 7 | TARTU ULIKOOL | EE (TARTU) | participant | 49˙500.00 |
| 8 | TALLINNA TEHNIKAULIKOOL | EE (TALLINN) | participant | 27˙000.00 |
| 9 | LINKOPINGS UNIVERSITET | SE (LINKOPING) | participant | 22˙500.00 |
| 10 | SIHTASUTUS TARTU ULIKOOLI KLIINIKUM | EE (TARTU) | participant | 9˙000.00 |
| 11 | ELVESYS | FR (PARIS) | participant | 4˙500.00 |
| 12 | HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ | FI (HELSINKI) | participant | 0.00 |
Map
Project objective
Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management costs making up ~3% of the total healthcare budget in the Western countries. The situation is even direr in some regions, including northern Sweden and Finland, where relative prevalence of SZ exceeds two to three times corresponding national or regional averages. Poorly understood aetiology and limited diagnostic arsenal make it difficult to detect and treat SZ in a timely and efficient manner. This underscores a critical need for better understanding of the mechanisms underlying SZ and development of new diagnostic possibilities allowing its early detection, ideally prior to the onset of psychosis. The SZ_TEST will address these challenges by coordinating efforts with complementary areas of expertise in genetics, epigenetics, neurodevelopment, molecular psychiatry, clinical immunology and biotech R&D. The overarching hypothesis underlying our work is that genetic vulnerabilities, neurodevelopmental defects, exposure to pathogens, immune system status and specific lifestyle choices may compound the risk of SZ and that a systematic multivariate analysis of these factors should result in substantially improved diagnostic tools. SZ_TEST will work towards the development of molecular diagnostics tools for early detection of SZ, by using relevant cohorts of human subjects, unique animal and cell models, and combining unbiased high-throughput omic screens with knowledge-based candidate marker analyses. SZ_TEST training network is expected to have a major impact on improving the quality of life and reducing the health care costs in Europe and worldwide.
Deliverables
| Promotional materials including a dedicated website | Websites, patent fillings, videos etc. | 2020-03-20 18:46:13 |
| Dissemination and communication plan | Other | 2020-03-20 18:46:14 |
Take a look to the deliverables list in detail: detailed list of SZ_TEST deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Eli-Eelika Esvald, Jürgen Tuvikene, Alex Sirp, Sudarshan Patil, Clive R. Bramham, Tõnis Timmusk CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons published pages: 0367-19, ISSN: 0270-6474, DOI: 10.1523/jneurosci.0367-19.2019 |
The Journal of Neuroscience | 2020-03-20 |
| 2020 |
Yaroslav A. Kainov, Eugene V. Makeyev A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-14204-z |
Nature Communications 11/1 | 2020-03-20 |
| 2017 |
Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild, Tõnis Timmusk The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A published pages: 10516-10527, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.1151-17.2017 |
The Journal of Neuroscience 37/43 | 2020-03-20 |
| 2017 |
Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski Recent advances in applying mass spectrometry and systems biology to determine brain dynamics published pages: 545-559, ISSN: 1478-9450, DOI: 10.1080/14789450.2017.1335200 |
Expert Review of Proteomics 14/6 | 2020-03-20 |
| 2018 |
Mehroz Ehsan, Matthew Kelly, Charlotte Hooper, Arash Yavari, Julia Beglov, Mohamed Bellahcene, Kirandeep Ghataorhe, Giulia Poloni, Anuj Goel, Theodosios Kyriakou, Karin Fleischanderl, Elisabeth Ehler, Eugene Makeyev, Stephan Lange, Houman Ashrafian, Charles Redwood, Benjamin Davies, Hugh Watkins, Katja Gehmlich Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion published pages: 287-296, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.07.248 |
Journal of Molecular and Cellular Cardiology 121 | 2020-03-20 |
| 2017 |
Dan Lindholm, Laura Korhonen, Ove Eriksson, Sulev Kõks Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2017.00048 |
Frontiers in Cell and Developmental Biology 5 | 2020-03-20 |
| 2018 |
Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling published pages: 47-59, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.01.043 |
EBioMedicine 29 | 2020-03-20 |
| 2018 |
Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin Täht, Jana Tuusov, Tanel Visnapuu, Jürgen Innos, Mohan Jayaram, Tõnis Timmusk, Cynthia S. Weickert, Marika Väli, Eero Vasar, Mari-Anne Philips Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2018.00008 |
Frontiers in Molecular Neuroscience 11 | 2020-03-20 |
| 2018 |
Karen Yap, Svetlana Mukhina, Gen Zhang, Jason S. C. Tan, Hong Sheng Ong, and Eugene V. Makeyev A short tandem repeat-enriched RNA assembles a nuclear compartment to control alternative splicing and promote cell survival published pages: , ISSN: , DOI: |
MolCell | 2020-03-20 |
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The information about "SZ_TEST" are provided by the European Opendata Portal: CORDIS opendata.