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SZ_TEST SIGNED

Towards Early Molecular Diagnostics of Schizophrenia

Total Cost €

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EC-Contrib. €

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Partnership

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 SZ_TEST project word cloud

Explore the words cloud of the SZ_TEST project. It provides you a very rough idea of what is the project "SZ_TEST" about.

severe    finland    underlying    countries    unbiased    lifestyle    western    globe    times    combining    population    exceeds    possibilities    arsenal    regional    nature    cohorts    total    corresponding    efficient    network    care    quality    prevalence    immune    worldwide    systematic    socioeconomic    epigenetics    considerable    genetics    mechanisms    adult    life    status    poorly    aetiology    animal    training    disorder    sweden    reducing    overarching    clinical    mental    schizophrenia    screens    situation    budget    chronic    detect    efforts    treat    diagnostic    disabling    man    immunology    exposure    defects    risk    human    hypothesis       fourth    tools       disability    burden    marker    prior    multivariate    ideally    vulnerabilities    molecular    emotionally    disease    pathogens    candidate    compound    neurodevelopmental    test    omic    onset    patient    substantially    diagnostics    critical    averages    models    psychosis    difficult    biotech    cell    neurodevelopment    devastating    relative    illnesses    sz    healthcare    genetic    national    underscores    northern    regions    direr    choices    complementary    health    degree    manner    psychiatry    subjects    throughput    detection    limited    expertise   

Project "SZ_TEST" data sheet

The following table provides information about the project.

Coordinator
PROTOBIOS OU 

Organization address
address: MAEALUSE 4
city: TALLINN
postcode: 12618
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Estonia [EE]
 Project website https://sztest.eu/
 Total cost 990˙000 €
 EC max contribution 990˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2016
 Funding Scheme MSCA-RISE
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PROTOBIOS OU EE (TALLINN) coordinator 414˙000.00
2    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 139˙500.00
3    SYSTASY BIOSCIENCE GMBH DE (MUNCHEN) participant 103˙500.00
4    OU QURETEC EE (TARTU) participant 85˙500.00
5    KING'S COLLEGE LONDON UK (LONDON) participant 76˙500.00
6    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 58˙500.00
7    TARTU ULIKOOL EE (TARTU) participant 49˙500.00
8    TALLINNA TEHNIKAULIKOOL EE (TALLINN) participant 27˙000.00
9    LINKOPINGS UNIVERSITET SE (LINKOPING) participant 22˙500.00
10    SIHTASUTUS TARTU ULIKOOLI KLIINIKUM EE (TARTU) participant 9˙000.00
11    ELVESYS FR (PARIS) participant 4˙500.00
12    HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ FI (HELSINKI) participant 0.00

Map

 Project objective

Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management costs making up ~3% of the total healthcare budget in the Western countries. The situation is even direr in some regions, including northern Sweden and Finland, where relative prevalence of SZ exceeds two to three times corresponding national or regional averages. Poorly understood aetiology and limited diagnostic arsenal make it difficult to detect and treat SZ in a timely and efficient manner. This underscores a critical need for better understanding of the mechanisms underlying SZ and development of new diagnostic possibilities allowing its early detection, ideally prior to the onset of psychosis. The SZ_TEST will address these challenges by coordinating efforts with complementary areas of expertise in genetics, epigenetics, neurodevelopment, molecular psychiatry, clinical immunology and biotech R&D. The overarching hypothesis underlying our work is that genetic vulnerabilities, neurodevelopmental defects, exposure to pathogens, immune system status and specific lifestyle choices may compound the risk of SZ and that a systematic multivariate analysis of these factors should result in substantially improved diagnostic tools. SZ_TEST will work towards the development of molecular diagnostics tools for early detection of SZ, by using relevant cohorts of human subjects, unique animal and cell models, and combining unbiased high-throughput omic screens with knowledge-based candidate marker analyses. SZ_TEST training network is expected to have a major impact on improving the quality of life and reducing the health care costs in Europe and worldwide.

 Deliverables

List of deliverables.
Promotional materials including a dedicated website Websites, patent fillings, videos etc. 2020-03-20 18:46:13
Dissemination and communication plan Other 2020-03-20 18:46:14

Take a look to the deliverables list in detail:  detailed list of SZ_TEST deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Eli-Eelika Esvald, Jürgen Tuvikene, Alex Sirp, Sudarshan Patil, Clive R. Bramham, Tõnis Timmusk
CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons
published pages: 0367-19, ISSN: 0270-6474, DOI: 10.1523/jneurosci.0367-19.2019
The Journal of Neuroscience 2020-03-20
2020 Yaroslav A. Kainov, Eugene V. Makeyev
A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-14204-z
Nature Communications 11/1 2020-03-20
2017 Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild, Tõnis Timmusk
The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A
published pages: 10516-10527, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.1151-17.2017
The Journal of Neuroscience 37/43 2020-03-20
2017 Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski
Recent advances in applying mass spectrometry and systems biology to determine brain dynamics
published pages: 545-559, ISSN: 1478-9450, DOI: 10.1080/14789450.2017.1335200
Expert Review of Proteomics 14/6 2020-03-20
2018 Mehroz Ehsan, Matthew Kelly, Charlotte Hooper, Arash Yavari, Julia Beglov, Mohamed Bellahcene, Kirandeep Ghataorhe, Giulia Poloni, Anuj Goel, Theodosios Kyriakou, Karin Fleischanderl, Elisabeth Ehler, Eugene Makeyev, Stephan Lange, Houman Ashrafian, Charles Redwood, Benjamin Davies, Hugh Watkins, Katja Gehmlich
Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion
published pages: 287-296, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.07.248
Journal of Molecular and Cellular Cardiology 121 2020-03-20
2017 Dan Lindholm, Laura Korhonen, Ove Eriksson, Sulev Kõks
Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease
published pages: , ISSN: 2296-634X, DOI: 10.3389/fcell.2017.00048
Frontiers in Cell and Developmental Biology 5 2020-03-20
2018 Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm
Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling
published pages: 47-59, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.01.043
EBioMedicine 29 2020-03-20
2018 Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin Täht, Jana Tuusov, Tanel Visnapuu, Jürgen Innos, Mohan Jayaram, Tõnis Timmusk, Cynthia S. Weickert, Marika Väli, Eero Vasar, Mari-Anne Philips
Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2018.00008
Frontiers in Molecular Neuroscience 11 2020-03-20
2018 Karen Yap, Svetlana Mukhina, Gen Zhang, Jason S. C. Tan, Hong Sheng Ong, and Eugene V. Makeyev
A short tandem repeat-enriched RNA assembles a nuclear compartment to control alternative splicing and promote cell survival
published pages: , ISSN: , DOI:
MolCell 2020-03-20

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