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EvISC

Infection of the human intestine by enteroviruses: A CRISPR-based screening approach

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EvISC project word cloud

Explore the words cloud of the EvISC project. It provides you a very rough idea of what is the project "EvISC" about.

intestinal    gastrointestinal    rna    jensen    biology    spread    poliovirus    academia    screen    opportunity    viruses    organs    picornaviridae    drug    cycle    lytic    belong    assemblage    therapies    expertise    cell    dissect    spectrum    demands    donors    health    enterovirus    genome    me    perspective    life    variations    integrating    13    lab    myself    vaccines    host    tapparel    cells    deletion    respectively    crispr    pathologies    human    survive    function    enteroviruses    guide    globally    tract    severe    primary    antivirals    genes    interdisciplinary    virus    performing    small    positive    respiratory    broad    entry    possibility    nature    pathogens    family    polio    interaction    diverse    stranded    epithelial    straightforward    hev    organoids    multiple    cultures    discovery    hevs    public    data    group    infected    infection    mediated    infections    pathogen    move    interactions    people    tropism    stem    species    exist    point    prominent    millions   

Project "EvISC" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://www.bric.ku.dk/Research/jensen_group/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

Enterovirus infections are of public health concern as globally millions of people become infected each year. Enteroviruses (HEV) are an assemblage of highly diverse positive-stranded RNA viruses that belong to the Picornaviridae family. Four out of the 13 known enterovirus species are human pathogens, with poliovirus being the most prominent member. The entry point for these viruses is the gastrointestinal or the respiratory tract from where they can spread to other organs and cause severe pathologies. Vaccines exist only against polio and no therapies are currently available against any HEV. Thus, there is a great need for new antivirals. I aim to identify host factors crucial for the HEV life cycle by performing a whole genome CRISPR loss-of-function screen in primary cultures of human intestinal epithelial cells. Importantly, the lytic nature of HEVs will allow a straightforward selection of cells that survive virus infection upon small guide RNA-mediated deletion of host genes that support HEV infection. This interdisciplinary project demands expertise both in stem cell, enterovirus biology and host-pathogen interaction, which is provided by the Jensen lab (host), the Tapparel lab (partner) and myself, respectively. Through access to intestinal stem cells and organoids from various donors and multiple HEVs I have the unique possibility to dissect host-enterovirus interactions by taking host and virus variations into account. By integrating this data, I will be able to dissect tropism both from a host and a pathogen perspective, and identify host factors that are necessary for HEV infection. This knowledge will contribute to the discovery of novel drug targets for broad-spectrum therapies against HEV infections and moreover provide me with the unique opportunity to move forward in academia and establish my own research group.

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The information about "EVISC" are provided by the European Opendata Portal: CORDIS opendata.

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