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EvISC

Infection of the human intestine by enteroviruses: A CRISPR-based screening approach

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 EvISC project word cloud

Explore the words cloud of the EvISC project. It provides you a very rough idea of what is the project "EvISC" about.

family    survive    spread    13    pathologies    dissect    biology    cultures    lab    diverse    polio    infection    prominent    poliovirus    infected    spectrum    picornaviridae    stranded    hevs    primary    me    multiple    vaccines    millions    cell    lytic    pathogens    move    species    interaction    genes    perspective    crispr    small    opportunity    human    tapparel    variations    point    possibility    integrating    rna    stem    cycle    host    antivirals    interdisciplinary    academia    myself    function    virus    respectively    organs    belong    public    nature    intestinal    tropism    performing    organoids    health    cells    epithelial    entry    group    respiratory    data    enteroviruses    hev    expertise    straightforward    jensen    tract    therapies    gastrointestinal    life    assemblage    viruses    mediated    globally    positive    screen    pathogen    enterovirus    severe    people    deletion    broad    demands    exist    interactions    discovery    donors    drug    genome    infections    guide   

Project "EvISC" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://www.bric.ku.dk/Research/jensen_group/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

Enterovirus infections are of public health concern as globally millions of people become infected each year. Enteroviruses (HEV) are an assemblage of highly diverse positive-stranded RNA viruses that belong to the Picornaviridae family. Four out of the 13 known enterovirus species are human pathogens, with poliovirus being the most prominent member. The entry point for these viruses is the gastrointestinal or the respiratory tract from where they can spread to other organs and cause severe pathologies. Vaccines exist only against polio and no therapies are currently available against any HEV. Thus, there is a great need for new antivirals. I aim to identify host factors crucial for the HEV life cycle by performing a whole genome CRISPR loss-of-function screen in primary cultures of human intestinal epithelial cells. Importantly, the lytic nature of HEVs will allow a straightforward selection of cells that survive virus infection upon small guide RNA-mediated deletion of host genes that support HEV infection. This interdisciplinary project demands expertise both in stem cell, enterovirus biology and host-pathogen interaction, which is provided by the Jensen lab (host), the Tapparel lab (partner) and myself, respectively. Through access to intestinal stem cells and organoids from various donors and multiple HEVs I have the unique possibility to dissect host-enterovirus interactions by taking host and virus variations into account. By integrating this data, I will be able to dissect tropism both from a host and a pathogen perspective, and identify host factors that are necessary for HEV infection. This knowledge will contribute to the discovery of novel drug targets for broad-spectrum therapies against HEV infections and moreover provide me with the unique opportunity to move forward in academia and establish my own research group.

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The information about "EVISC" are provided by the European Opendata Portal: CORDIS opendata.

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