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EvISC

Infection of the human intestine by enteroviruses: A CRISPR-based screening approach

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EvISC project word cloud

Explore the words cloud of the EvISC project. It provides you a very rough idea of what is the project "EvISC" about.

13    guide    positive    possibility    drug    respectively    lab    picornaviridae    variations    family    pathogens    millions    globally    academia    intestinal    organs    demands    rna    opportunity    life    prominent    hevs    infection    spectrum    small    poliovirus    straightforward    organoids    assemblage    diverse    viruses    primary    group    performing    lytic    function    deletion    crispr    respiratory    public    exist    discovery    interaction    antivirals    human    cycle    interdisciplinary    pathogen    broad    health    tapparel    people    multiple    gastrointestinal    genes    data    spread    interactions    infections    jensen    species    belong    mediated    biology    tropism    survive    virus    cell    vaccines    entry    polio    dissect    tract    therapies    enterovirus    point    myself    screen    cells    perspective    expertise    integrating    cultures    move    epithelial    donors    me    stem    infected    stranded    pathologies    genome    host    severe    enteroviruses    hev    nature   

Project "EvISC" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website https://www.bric.ku.dk/Research/jensen_group/
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

Enterovirus infections are of public health concern as globally millions of people become infected each year. Enteroviruses (HEV) are an assemblage of highly diverse positive-stranded RNA viruses that belong to the Picornaviridae family. Four out of the 13 known enterovirus species are human pathogens, with poliovirus being the most prominent member. The entry point for these viruses is the gastrointestinal or the respiratory tract from where they can spread to other organs and cause severe pathologies. Vaccines exist only against polio and no therapies are currently available against any HEV. Thus, there is a great need for new antivirals. I aim to identify host factors crucial for the HEV life cycle by performing a whole genome CRISPR loss-of-function screen in primary cultures of human intestinal epithelial cells. Importantly, the lytic nature of HEVs will allow a straightforward selection of cells that survive virus infection upon small guide RNA-mediated deletion of host genes that support HEV infection. This interdisciplinary project demands expertise both in stem cell, enterovirus biology and host-pathogen interaction, which is provided by the Jensen lab (host), the Tapparel lab (partner) and myself, respectively. Through access to intestinal stem cells and organoids from various donors and multiple HEVs I have the unique possibility to dissect host-enterovirus interactions by taking host and virus variations into account. By integrating this data, I will be able to dissect tropism both from a host and a pathogen perspective, and identify host factors that are necessary for HEV infection. This knowledge will contribute to the discovery of novel drug targets for broad-spectrum therapies against HEV infections and moreover provide me with the unique opportunity to move forward in academia and establish my own research group.

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The information about "EVISC" are provided by the European Opendata Portal: CORDIS opendata.

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