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RABYD-VAX SIGNED

Development of a Next-Generation, Dual-Target Rabies/Flavivirus Infectious DNA (iDNA) Vaccine

Total Cost €

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EC-Contrib. €

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Partnership

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 RABYD-VAX project word cloud

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Project "RABYD-VAX" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://rabyd-vax.eu/
 Total cost 4˙113˙385 €
 EC max contribution 4˙113˙385 € (100%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙818˙113.00
2    THE SECRETARY OF STATE FOR ENVIRONMENT, FOOD AND RURAL AFFAIRS UK (LONDON) participant 827˙107.00
3    STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER NL (RIJSWIJK ZH) participant 818˙458.00
4    SCIENSANO BE (ELSENE) participant 649˙705.00
5    INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE BE (BRUXELLES) participant 0.00

Map

 Project objective

Rabies is the deadliest disease on earth (99.9% fatality rate). Annually, ~58.000 people die from rabies, more than half of them are children. Many remain unvaccinated because of the high costs and the need for a cold-chain. Likewise, despite the existence of an excellent yellow fever (YF) vaccine, yearly ~30.000 people die of YF. The 80-year old low-tech production process does not allow to produce sufficient doses. There is now a real danger that major YF-outbreaks become uncontrollable. We aim at developing an efficient, safe, cheap, thermostable and easy-to-produce vaccine that can be needle-free administered, that protects against both rabies and YF, and that can be implemented in routine prophylactic paediatric vaccination. For this, we will employ our (P01a) proprietary infectious DNA (iDNA) vaccine technology. Simple, even needle-free injection of a low dose (1-10µg) of this easy-to-produce naked plasmid in mice and hamsters launches the YF vaccine virus and protects hamsters as efficiently as the commercial vaccine against lethal YF challenge. The iDNA YF vaccine will be used as vector to express relevant protective rabies antigens. Dual protection of such chimeric iDNA rabies/YF vaccine will be demonstrated against lethal rabies and YFV challenge in small animal models. Likewise, chimeric rabies/Japanese encephalitis and rabies/Zika virus iDNA vaccine candidates will be generated using this versatile platform. Next, induction of protective immunity will be demonstrated in rhesus macaques. The iDNA vaccines combine the benefits of both the YF live-attenuated vaccine (highly efficient life-long induction of immunity) and the thermo-stability, ease-of-production and the potential to customize (in response to emerging medical needs) of “classical” DNA vaccines. A path towards advanced pre-clinical and clinical development of such novel vaccines will be developed in compliance with European regulatory and WHO prequalification requirements.

 Deliverables

List of deliverables.
Dissemination and Communication Measures Documents, reports 2019-05-31 16:34:02

Take a look to the deliverables list in detail:  detailed list of RABYD-VAX deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Rebecca Shipley, Edward Wright, David Selden, Guanghui Wu, James Aegerter, Anthony R Fooks, Ashley C Banyard
Bats and Viruses: Emergence of Novel Lyssaviruses and Association of Bats with Viral Zoonoses in the EU
published pages: 31, ISSN: 2414-6366, DOI: 10.3390/tropicalmed4010031
Tropical Medicine and Infectious Disease 4/1 2020-03-11
2018 Dieudonné B. Kum, Niraj Mishra, Robbert Boudewijns, Ivan Gladwyn-Ng, Christian Alfano, Ji Ma, Michael A. Schmid, Rafael E. Marques, Dominique Schols, Suzanne Kaptein, Laurent Nguyen, Johan Neyts, Kai Dallmeier
A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice
published pages: , ISSN: 2059-0105, DOI: 10.1038/s41541-018-0092-2
npj Vaccines 3/1 2020-03-11
2018 Ashley C. Banyard, David Selden, Guanghui Wu, Leigh Thorne, Daisy Jennings, Denise Marston, Stefan Finke, Conrad M. Freuling, Thomas Müller, Juan E. Echevarría, Anthony R. Fooks
Isolation, antigenicity and immunogenicity of Lleida bat lyssavirus
published pages: 1590-1599, ISSN: 0022-1317, DOI: 10.1099/jgv.0.001068
Journal of General Virology 99/12 2020-03-11
2019 Dieudonné Buh Kum, Niraj Mishra, Bram Vrancken, Hendrik Jan Thibaut, Annelies Wilder-Smith, Philippe Lemey, Johan Neyts, Kai Dallmeier
Limited evolution of the yellow fever virus 17d in a mouse infection model
published pages: 1734-1746, ISSN: 2222-1751, DOI: 10.1080/22221751.2019.1694394
Emerging Microbes & Infections 8/1 2020-03-11
2019 Samuel P. Smith, Guanghui Wu, Anthony R. Fooks, Julian Ma, Ashley C. Banyard
Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS
published pages: 1171-1186, ISSN: 0022-1317, DOI: 10.1099/jgv.0.001269
Journal of General Virology 100/8 2020-03-11
2018 Jennifer Evans, Guanghui Wu, David Selden, Hubert Buczkowski, Leigh Thorne, Anthony Fooks, Ashley Banyard
Utilisation of Chimeric Lyssaviruses to Assess Vaccine Protection against Highly Divergent Lyssaviruses
published pages: 130, ISSN: 1999-4915, DOI: 10.3390/v10030130
Viruses 10/3 2019-06-11
2018 E. Kip, J. Staal, L. Verstrepen, H. G. Tima, S. Terryn, M. Romano, K. Lemeire, V. Suin, A. Hamouda, M. Kalai, R. Beyaert, S. Van Gucht
MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain
published pages: , ISSN: 0022-538X, DOI: 10.1128/JVI.02029-17
Journal of Virology 92/8 2019-06-11

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