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Integrated Tissue Slice Culture and NMR Metabolomics – A Novel Approach Towards SystemicUnderstanding of Liver Function And Disease

Total Cost €


EC-Contrib. €






Project "TISuMR" data sheet

The following table provides information about the project.


Organization address
address: Highfield
postcode: SO17 1BJ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 3˙138˙432 €
 EC max contribution 3˙138˙432 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF SOUTHAMPTON UK (SOUTHAMPTON) coordinator 1˙256˙126.00


 Project objective

We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolic study of tissues at the system level.

Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level. The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.

It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries. Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.

TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing, and by enabling new treatments in the management of liver disease.


List of deliverables.
Optimised TLP-NMR System Documents, reports 2020-02-12 15:32:11
Report on project symposium 1 Documents, reports 2019-05-14 15:49:50
Selection of protocols for tissue harvest and incubation Documents, reports 2019-05-14 15:49:50
Project website Websites, patent fillings, videos etc. 2019-05-14 15:49:50
Press releases Websites, patent fillings, videos etc. 2019-05-14 15:49:50
Protocols for exposure of liver slices to 2-3 selected cholestatic drugs Documents, reports 2019-05-14 15:49:50
Project Identity Websites, patent fillings, videos etc. 2019-05-14 15:49:50

Take a look to the deliverables list in detail:  detailed list of TISuMR deliverables.


year authors and title journal last update
List of publications.
2019 Lorenzo Bordonali, Nurdiana Nordin, Erwin Fuhrer, Neil MacKinnon, Jan G. Korvink
Parahydrogen based NMR hyperpolarisation goes micro: an alveolus for small molecule chemosensing
published pages: 503-512, ISSN: 1473-0197, DOI: 10.1039/c8lc01259h
Lab on a Chip 19/3 2020-01-14
2019 Hossein Davoodi, Mazin Jouda, Jan G. Korvink, Neil MacKinnon, Vlad Badilita
Broadband and multi-resonant sensors for NMR
published pages: 34-54, ISSN: 0079-6565, DOI: 10.1016/j.pnmrs.2019.05.001
Progress in Nuclear Magnetic Resonance Spectroscopy 112-113 2020-01-14
2019 Yongbo Deng, Zhenyu Liu, Yasi Wang, Huigao Duan, Jan G. Korvink
Micro-textures inversely designed with overlayed-lithography manufacturability for wetting behavior in Cassie–Baxter status
published pages: 621-640, ISSN: 0307-904X, DOI: 10.1016/j.apm.2019.04.059
Applied Mathematical Modelling 74 2020-01-14
2019 Jan G. Korvink, Neil MacKinnon, Vlad Badilita, Mazin Jouda
“Small is beautiful” in NMR
published pages: 112-117, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.07.012
Journal of Magnetic Resonance 306 2020-01-14
2019 Erwin Fuhrer, Mazin Jouda, Christopher O. Klein, Manfred Wilhelm, Jan G. Korvink
Gradient-induced mechanical vibration of neural interfaces during MRI
published pages: 1-1, ISSN: 0018-9294, DOI: 10.1109/tbme.2019.2923693
IEEE Transactions on Biomedical Engineering 2020-01-14
2019 Mazin Jouda, Erwin Fuhrer, Pedro Silva, Jan G. Korvink, Neil MacKinnon
Automatic Adaptive Gain for Magnetic Resonance Sensitivity Enhancement
published pages: 2376-2383, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b05148
Analytical Chemistry 91/3 2020-01-14
2019 Pedro F. Silva, Saraí M. Torres Delgado, Mazin Jouda, Dario Mager, Jan G. Korvink
A multi-purpose, rolled-up, double-helix resonator
published pages: 106599, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.106599
Journal of Magnetic Resonance 309 2020-01-14
2019 Manvendra Sharma, Marcel Utz
Modular transmission line probes for microfluidic nuclear magnetic resonance spectroscopy and imaging
published pages: 75-81, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.04.007
Journal of Magnetic Resonance 303 2019-11-26
2018 Hongxun Fang, Yibin Sun, Xinchang Wang, Manvendra Sharma, Zhong Chen, Xiaoyu Cao, Marcel Utz, Zhongqun Tian
Probing the kinetics in supramolecular chemistry and molecular assembly by microfluidic-NMR spectroscopy
published pages: 1460-1464, ISSN: 1674-7291, DOI: 10.1007/s11426-018-9293-3
Science China Chemistry 61/11 2019-05-14
2018 William Hale, Gabriel Rossetto, Rachael Greenhalgh, Graeme Finch, Marcel Utz
High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets
published pages: 3018-3024, ISSN: 1473-0197, DOI: 10.1039/c8lc00712h
Lab on a Chip 18/19 2019-05-14
2018 Saraí M. Torres Delgado, Jan G. Korvink, Dario Mager
The eLoaD platform endows centrifugal microfluidics with on-disc power and communication
published pages: 464-473, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.05.056
Biosensors and Bioelectronics 117 2019-05-14

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