Explore the words cloud of the TISuMR project. It provides you a very rough idea of what is the project "TISuMR" about.
The following table provides information about the project.
UNIVERSITY OF SOUTHAMPTON
|Coordinator Country||United Kingdom [UK]|
|Total cost||3˙138˙432 €|
|EC max contribution||3˙138˙432 € (100%)|
1. H2020-EU.1.2.1. (FET Open)
|Duration (year-month-day)||from 2017-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||UNIVERSITY OF SOUTHAMPTON||UK (SOUTHAMPTON)||coordinator||1˙256˙126.00|
|2||KARLSRUHER INSTITUT FUER TECHNOLOGIE||DE (KARLSRUHE)||participant||947˙185.00|
|3||RIJKSUNIVERSITEIT GRONINGEN||NL (GRONINGEN)||participant||935˙121.00|
We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolic study of tissues at the system level.
Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level. The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.
It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries. Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.
TISuMR will have a profound impact on wider society by providing alternatives to animal testing, by increasing the efficiency and specificity of drug safety testing, and by enabling new treatments in the management of liver disease.
|Optimised TLP-NMR System||Documents, reports||2020-02-12 15:32:11|
|Report on project symposium 1||Documents, reports||2019-05-14 15:49:50|
|Selection of protocols for tissue harvest and incubation||Documents, reports||2019-05-14 15:49:50|
|Project website||Websites, patent fillings, videos etc.||2019-05-14 15:49:50|
|Press releases||Websites, patent fillings, videos etc.||2019-05-14 15:49:50|
|Protocols for exposure of liver slices to 2-3 selected cholestatic drugs||Documents, reports||2019-05-14 15:49:50|
|Project Identity||Websites, patent fillings, videos etc.||2019-05-14 15:49:50|
Take a look to the deliverables list in detail: detailed list of TISuMR deliverables.
|year||authors and title||journal||last update|
Lorenzo Bordonali, Nurdiana Nordin, Erwin Fuhrer, Neil MacKinnon, Jan G. Korvink
Parahydrogen based NMR hyperpolarisation goes micro: an alveolus for small molecule chemosensing
published pages: 503-512, ISSN: 1473-0197, DOI: 10.1039/c8lc01259h
|Lab on a Chip 19/3||2020-01-14|
Hossein Davoodi, Mazin Jouda, Jan G. Korvink, Neil MacKinnon, Vlad Badilita
Broadband and multi-resonant sensors for NMR
published pages: 34-54, ISSN: 0079-6565, DOI: 10.1016/j.pnmrs.2019.05.001
|Progress in Nuclear Magnetic Resonance Spectroscopy 112-113||2020-01-14|
Yongbo Deng, Zhenyu Liu, Yasi Wang, Huigao Duan, Jan G. Korvink
Micro-textures inversely designed with overlayed-lithography manufacturability for wetting behavior in Cassieâ€“Baxter status
published pages: 621-640, ISSN: 0307-904X, DOI: 10.1016/j.apm.2019.04.059
|Applied Mathematical Modelling 74||2020-01-14|
Jan G. Korvink, Neil MacKinnon, Vlad Badilita, Mazin Jouda
â€œSmall is beautifulâ€ in NMR
published pages: 112-117, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.07.012
|Journal of Magnetic Resonance 306||2020-01-14|
Erwin Fuhrer, Mazin Jouda, Christopher O. Klein, Manfred Wilhelm, Jan G. Korvink
Gradient-induced mechanical vibration of neural interfaces during MRI
published pages: 1-1, ISSN: 0018-9294, DOI: 10.1109/tbme.2019.2923693
|IEEE Transactions on Biomedical Engineering||2020-01-14|
Mazin Jouda, Erwin Fuhrer, Pedro Silva, Jan G. Korvink, Neil MacKinnon
Automatic Adaptive Gain for Magnetic Resonance Sensitivity Enhancement
published pages: 2376-2383, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b05148
|Analytical Chemistry 91/3||2020-01-14|
Pedro F. Silva, SaraÃ M. Torres Delgado, Mazin Jouda, Dario Mager, Jan G. Korvink
A multi-purpose, rolled-up, double-helix resonator
published pages: 106599, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.106599
|Journal of Magnetic Resonance 309||2020-01-14|
Manvendra Sharma, Marcel Utz
Modular transmission line probes for microfluidic nuclear magnetic resonance spectroscopy and imaging
published pages: 75-81, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.04.007
|Journal of Magnetic Resonance 303||2019-11-26|
Hongxun Fang, Yibin Sun, Xinchang Wang, Manvendra Sharma, Zhong Chen, Xiaoyu Cao, Marcel Utz, Zhongqun Tian
Probing the kinetics in supramolecular chemistry and molecular assembly by microfluidic-NMR spectroscopy
published pages: 1460-1464, ISSN: 1674-7291, DOI: 10.1007/s11426-018-9293-3
|Science China Chemistry 61/11||2019-05-14|
William Hale, Gabriel Rossetto, Rachael Greenhalgh, Graeme Finch, Marcel Utz
High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets
published pages: 3018-3024, ISSN: 1473-0197, DOI: 10.1039/c8lc00712h
|Lab on a Chip 18/19||2019-05-14|
SaraÃ M. Torres Delgado, Jan G. Korvink, Dario Mager
The eLoaD platform endows centrifugal microfluidics with on-disc power and communication
published pages: 464-473, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.05.056
|Biosensors and Bioelectronics 117||2019-05-14|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TISUMR" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "TISUMR" are provided by the European Opendata Portal: CORDIS opendata.