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HIVACAR SIGNED

Evaluating a Combination of Immune-based Therapies to Achieve a Functional Cure of HIV Infection

Total Cost €

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EC-Contrib. €

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Partnership

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Project "HIVACAR" data sheet

The following table provides information about the project.

Coordinator
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER 

Organization address
address: CALLE ROSSELLO 149 PUERTA BJS
city: BARCELONA
postcode: 8036
website: http://www.idibaps.org/en_index.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.hivacar.org/
 Total cost 6˙822˙299 €
 EC max contribution 6˙685˙111 € (98%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER ES (BARCELONA) coordinator 2˙859˙183.00
2    FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA ES (BARCELONA) participant 714˙375.00
3    THE ROCKEFELLER UNIVERSITY NOT FOR PROFIT CORPORATION US (NEW YORK) participant 706˙250.00
4    AARHUS UNIVERSITET DK (AARHUS C) participant 496˙250.00
5    ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK FR (PARIS) participant 309˙275.00
6    ZABALA INNOVATION CONSULTING, S.A. ES (MUTILVA ALTA NAVARRA) participant 273˙125.00
7    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 238˙063.00
8    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 216˙236.00
9    ETHERNA IMMUNOTHERAPIES BE (NIEL) participant 215˙000.00
10    VRIJE UNIVERSITEIT BRUSSEL BE (BRUSSEL) participant 198˙360.00
11    ASPHALION SL ES (BARCELONA) participant 175˙000.00
12    EUROPEAN AIDS TREATMENT GROUP EV DE (DUSSELDORF) participant 150˙000.00
13    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) participant 128˙750.00
14    AELIX THERAPEUTICS SL ES (BARCELONA) participant 5˙242.00
15    Simon Fraser University CA (BURNABY) participant 0.00

Map

 Project objective

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4 T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planned novel strategy is to successfully combine immune-based therapies, including therapeutic vaccines and broadly neutralizing antibodies with latency reversing agents, in a proof-of-concept phase IIa clinical trial. HIVACAR project will lead to a reduction of the actual costs related to HIV treatment and management and of the social public health as well as an improvement in the patients’ quality of life. HIVACAR project has been conceived under the framework of responsible research and innovation, so patients and other stakeholders will have a key role from the inception of the project until obtaining the results. Patients will be perfectly aware of how this therapy has been conceived and the real impact and change in their actual quality of life, as well as how the clinical trial has been designed and the consequences of participating in it. In addition, patients (and the general population) will tailor the project and its results dissemination and communication. This patient engagement will not be limited to the clinical trial but also to the rest of the activities of the project, so patients and the general society will be aware of how the research is developed and can include the patients’ point of view in the research activities. In addition, the socio-economic and psycho-social impact of the new treatment will be also analysed so overwhelming data on the benefits and impact of the new treatment will be obtained and shown to all the stakeholders.

 Deliverables

List of deliverables.
Intermediate report on dissemination activities Documents, reports 2020-02-19 17:35:24
Targeted communication tools Documents, reports 2020-02-19 17:35:24
Final Briefing Document sent to EMA to request Scientific Advice containing information on the quality, nonclinical and clinical development program Documents, reports 2020-02-19 17:35:24
Data Management Plan Documents, reports 2020-02-19 17:35:24
Communication plan Other 2020-02-19 17:35:24
HIVACAR Phase I/IIa clinical trial protocol Documents, reports 2020-02-19 17:35:24

Take a look to the deliverables list in detail:  detailed list of HIVACAR deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Oscar S. Sorzano, Lidia Saiz, Pilar Mediavilla, Mariano Esteban, Carmen Elena Gómez
A Novel MVA-Based HIV Vaccine Candidate (MVA-gp145-GPN) Co-Expressing Clade C Membrane-Bound Trimeric gp145 Env and Gag-Induced Virus-Like Particles (VLPs) Triggered Broad and Multifunctional HIV-1-Specific T Cell and Antibody Responses
published pages: 160, ISSN: 1999-4915, DOI: 10.3390/v11020160
Viruses 11(2) 2020-02-19
2018 Beatriz Perdiguero; Suresh C. Raman; Cristina Sánchez-Corzo; Carlos Oscar S. Sorzano; José Ramón Valverde; Mariano Esteban; Carmen Elena Gómez
Potent HIV-1-Specific CD8 T Cell Responses Induced in Mice after Priming with a Multiepitopic DNA-TMEP and Boosting with the HIV Vaccine MVA-B
published pages: 424, ISSN: 1999-4915, DOI: 10.3390/v10080424
Viruses 10(8) 2020-02-19

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The information about "HIVACAR" are provided by the European Opendata Portal: CORDIS opendata.

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