Explore the words cloud of the PAPA-ARTIS project. It provides you a very rough idea of what is the project "PAPA-ARTIS" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||6˙187˙672 €|
|EC max contribution||5˙913˙922 € (96%)|
1. H2020-EU.3.1.3. (Treating and managing disease)
|Duration (year-month-day)||from 2017-01-01 to 2021-12-31|
Take a look of project's partnership.
|1||UNIVERSITAET LEIPZIG||DE (LEIPZIG)||coordinator||2˙535˙455.00|
|2||ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK||FR (PARIS)||participant||364˙750.00|
|3||UNIVERSIDAD DE GRANADA||ES (GRANADA)||participant||262˙596.00|
|4||OREBRO LANS LANDSTING||SE (OREBRO)||participant||229˙575.00|
|5||ACADEMISCH ZIEKENHUIS MAASTRICHT||NL (MAASTRICHT)||participant||223˙852.00|
|6||SKANE LANS LANDSTING||SE (KRISTIANSTAD)||participant||221˙302.00|
|7||UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF||DE (HAMBURG)||participant||216˙565.00|
|8||UNIVERSITAETSKLINIKUM FREIBURG||DE (FREIBURG)||participant||216˙563.00|
|9||LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN||DE (MUENCHEN)||participant||216˙562.00|
|10||ASSOCIATION MARIE LANNELONGUE||FR (LE PLESSIS ROBINSON)||participant||201˙307.00|
|11||BARTS AND THE LONDON NHS TRUST||UK (LONDON)||participant||179˙162.00|
|12||OSPEDALE SAN RAFFAELE SRL||IT (MILANO)||participant||166˙368.00|
|13||CHU HOPITAUX DE BORDEAUX||FR (TALENCE)||participant||159˙820.00|
|14||WARSZAWSKI UNIWERSYTET MEDYCZNY||PL (WARSZAWA)||participant||131˙875.00|
|15||ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA||IT (BOLOGNA)||participant||127˙156.00|
|16||SLASKIE CENTRUM CHOROB SERCA W ZABRZU||PL (ZABRZE)||participant||119˙910.00|
|17||MODUS RESEARCH AND INNOVATION LIMITED||UK (EDINBURGH)||participant||104˙006.00|
|18||SOCIETE EUROPEENNE DE CARDIOLOGIE||FR (BIOT SOPHIA ANTIPOLIS)||participant||68˙750.00|
|19||REGION HOVEDSTADEN||DK (HILLEROD)||participant||60˙687.00|
|20||BAYLOR COLLEGE OF MEDICINE||US (HOUSTON TX)||participant||50˙420.00|
|21||THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP||US (PHILADELPHIA)||participant||50˙420.00|
|22||KITE INNOVATION (EUROPE) LIMITED||UK (HUDDERSFIELD)||participant||6˙816.00|
|23||Insel Gruppe AG||CH (BERN)||participant||0.00|
|24||LIVERPOOL HEART AND CHEST HOSPITAL NHS FOUNDATION TRUST||UK (LIVERPOOL)||participant||0.00|
|25||UNIVERSITE DE LILLE||FR (LILLE)||participant||0.00|
|26||UNIVERSITE DE LILLE II - DROIT ET SANTE||FR (Lille)||participant||0.00|
Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in paraplegia from spinal cord ischaemia or even death, particularly for aneurysms extending from the thoracic to the abdominal aorta and thus involving many segmental arteries to the spinal cord, i.e. thoracoabdominal aortic aneurysms of Crawford type II. Although various strategies have achieved a remarkable decrease in the incidence of paraplegia, it is still no less than 10 to 20%. However, it has been found that the deliberate occlusion of the segmental arteries to the paraspinous collateral network finally supplying the spinal cord does not increase rates of permanent paraplegia. A therapeutic option, ‘minimally invasive segmental artery coil embolization’ has been devised which proceeds in a ‘staged’ way to occlude groups of arteries under highly controlled conditions after which time must be allowed for arteriogenesis to build a robust collateral blood supply. PAPA-ARTiS is a phase II trial to demonstrate that a staged treatment approach can reduce paraplegia and mortality dramatically. It can be expected to have both a dramatic impact on the individual patient's quality of life if saved from a wheelchair, and also upon financial systems through savings in; 1) lower costs in EU health care; 2) lower pay-outs in disability insurance (est. at 500k in Year 1), and; 3) loss of economic output from unemployment. Approx. 2500 patients a year in Europe undergo these high risk operations with a cumulative paraplegia rate of over 15%; therefore >100M per year in costs can be avoided and significantly more considering the expected elimination of type II endoleaks.
|Ethical guidance document||Documents, reports||2020-01-23 12:42:06|
|Links with existing projects/professional bodies||Documents, reports||2020-01-23 12:42:06|
|PAPA-ARTiS Project Management Handbook||Documents, reports||2020-01-23 12:42:06|
|Communication strategy||Documents, reports||2020-01-23 12:42:06|
|Project Data Management Plan||Documents, reports||2020-01-23 12:42:06|
|Trial registration||Other||2020-01-23 12:42:06|
|Clinical Trial Data Management plan||Documents, reports||2020-01-23 12:42:06|
Take a look to the deliverables list in detail: detailed list of PAPA-ARTIS deliverables.
|year||authors and title||journal||last update|
David Petroff, Martin Czerny, Tilo KÃ¶lbel, Germano Melissano, Lars Lonn, Josephina Haunschild, Konstantin von Aspern, Petra Neuhaus, Johann Pelz, David Epstein, Nuria Romo-AvilÃ©s, Katja Piotrowski, Christian D Etz
Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with â€˜Minimally-Invasive Staged Segmental Artery Coil-Embolizationâ€™ (MISÂ²ACE): Trial protocol for a Randomized Controlled Multicentre Trial.
published pages: , ISSN: 2044-6055, DOI:
|BMJ Open Volume 9, Issue 3||2020-01-23|
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The information about "PAPA-ARTIS" are provided by the European Opendata Portal: CORDIS opendata.
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