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PAPA-ARTIS SIGNED

Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with ‘Minimally-Invasive Segmental Artery Coil-Embolization’: A Randomized Controlled Multicentre Trial

Total Cost €

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EC-Contrib. €

0

Partnership

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 PAPA-ARTIS project word cloud

Explore the words cloud of the PAPA-ARTIS project. It provides you a very rough idea of what is the project "PAPA-ARTIS" about.

rates    abdominal    approx    chronic    collateral    strategies    care    arteries    health    sudden    supply    15    blood    asymptomatic    saved    est    thoracic    unemployment    undergo    cumulative    cures    incidence    remarkable    occlude    allowed    spinal    100m    500k    therapeutic    risk    2500    disease    embolization    disability    continue    ischaemia    arteriogenesis    diameter    life    localized    permanent    elimination    20    output    pay    rate    artis    dramatically    internal    successful    crawford    rupture    option    financial    minimally    time    supplying    prognosis    dismal    individual    thoracoabdominal    death    savings    brings    economic    proceeds    groups    paraplegia    patients    lower    devised    wheelchair    risky    invasive    network    found    dramatic    gt    outs    staged    patient    treatment    cord    occlusion    aortic    endoleaks    operations    significantly    papa    left    aneurysms    insurance    decrease    mortality    quality    paraspinous    periods    trial    deliberate    dilations    untreated    segmental    aorta    bleeding    considering    coil    reduce    artery   

Project "PAPA-ARTIS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET LEIPZIG 

Organization address
address: RITTERSTRASSE 26
city: LEIPZIG
postcode: 4109
website: www.uni-Ieipzig.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.papa-artis.eu/
 Total cost 6˙187˙672 €
 EC max contribution 5˙913˙922 € (96%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET LEIPZIG DE (LEIPZIG) coordinator 2˙535˙455.00
2    ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK FR (PARIS) participant 364˙750.00
3    UNIVERSIDAD DE GRANADA ES (GRANADA) participant 262˙596.00
4    OREBRO LANS LANDSTING SE (OREBRO) participant 229˙575.00
5    ACADEMISCH ZIEKENHUIS MAASTRICHT NL (MAASTRICHT) participant 223˙852.00
6    SKANE LANS LANDSTING SE (KRISTIANSTAD) participant 221˙302.00
7    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) participant 216˙565.00
8    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) participant 216˙563.00
9    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 216˙562.00
10    ASSOCIATION MARIE LANNELONGUE FR (LE PLESSIS ROBINSON) participant 201˙307.00
11    BARTS AND THE LONDON NHS TRUST UK (LONDON) participant 179˙162.00
12    OSPEDALE SAN RAFFAELE SRL IT (MILANO) participant 166˙368.00
13    CHU HOPITAUX DE BORDEAUX FR (TALENCE) participant 159˙820.00
14    WARSZAWSKI UNIWERSYTET MEDYCZNY PL (WARSZAWA) participant 131˙875.00
15    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 127˙156.00
16    SLASKIE CENTRUM CHOROB SERCA W ZABRZU PL (ZABRZE) participant 119˙910.00
17    MODUS RESEARCH AND INNOVATION LIMITED UK (EDINBURGH) participant 104˙006.00
18    SOCIETE EUROPEENNE DE CARDIOLOGIE FR (BIOT SOPHIA ANTIPOLIS) participant 68˙750.00
19    REGION HOVEDSTADEN DK (HILLEROD) participant 60˙687.00
20    BAYLOR COLLEGE OF MEDICINE US (HOUSTON TX) participant 50˙420.00
21    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP US (PHILADELPHIA) participant 50˙420.00
22    KITE INNOVATION (EUROPE) LIMITED UK (HUDDERSFIELD) participant 6˙816.00
23    Insel Gruppe AG CH (BERN) participant 0.00
24    LIVERPOOL HEART AND CHEST HOSPITAL NHS FOUNDATION TRUST UK (LIVERPOOL) participant 0.00
25    UNIVERSITE DE LILLE FR (LILLE) participant 0.00
26    UNIVERSITE DE LILLE II - DROIT ET SANTE FR (Lille) participant 0.00

Map

 Project objective

Chronic aortic aneurysms are permanent and localized dilations of the aorta that remain asymptomatic for long periods of time but continue to increase in diameter before they eventually rupture. Left untreated, the patients’ prognosis is dismal, since the internal bleeding of the rupture brings about sudden death. Although successful treatment cures the disease, the risky procedures can result in paraplegia from spinal cord ischaemia or even death, particularly for aneurysms extending from the thoracic to the abdominal aorta and thus involving many segmental arteries to the spinal cord, i.e. thoracoabdominal aortic aneurysms of Crawford type II. Although various strategies have achieved a remarkable decrease in the incidence of paraplegia, it is still no less than 10 to 20%. However, it has been found that the deliberate occlusion of the segmental arteries to the paraspinous collateral network finally supplying the spinal cord does not increase rates of permanent paraplegia. A therapeutic option, ‘minimally invasive segmental artery coil embolization’ has been devised which proceeds in a ‘staged’ way to occlude groups of arteries under highly controlled conditions after which time must be allowed for arteriogenesis to build a robust collateral blood supply. PAPA-ARTiS is a phase II trial to demonstrate that a staged treatment approach can reduce paraplegia and mortality dramatically. It can be expected to have both a dramatic impact on the individual patient's quality of life if saved from a wheelchair, and also upon financial systems through savings in; 1) lower costs in EU health care; 2) lower pay-outs in disability insurance (est. at 500k in Year 1), and; 3) loss of economic output from unemployment. Approx. 2500 patients a year in Europe undergo these high risk operations with a cumulative paraplegia rate of over 15%; therefore >100M per year in costs can be avoided and significantly more considering the expected elimination of type II endoleaks.

 Deliverables

List of deliverables.
Ethical guidance document Documents, reports 2020-01-23 12:42:06
Links with existing projects/professional bodies Documents, reports 2020-01-23 12:42:06
PAPA-ARTiS Project Management Handbook Documents, reports 2020-01-23 12:42:06
Communication strategy Documents, reports 2020-01-23 12:42:06
Project Data Management Plan Documents, reports 2020-01-23 12:42:06
Trial registration Other 2020-01-23 12:42:06
Clinical Trial Data Management plan Documents, reports 2020-01-23 12:42:06

Take a look to the deliverables list in detail:  detailed list of PAPA-ARTIS deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 David Petroff, Martin Czerny, Tilo Kölbel, Germano Melissano, Lars Lonn, Josephina Haunschild, Konstantin von Aspern, Petra Neuhaus, Johann Pelz, David Epstein, Nuria Romo-Avilés, Katja Piotrowski, Christian D Etz
Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging with ‘Minimally-Invasive Staged Segmental Artery Coil-Embolization’ (MIS²ACE): Trial protocol for a Randomized Controlled Multicentre Trial.
published pages: , ISSN: 2044-6055, DOI:
BMJ Open Volume 9, Issue 3 2020-01-23

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