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MYCONEUTROPHILS SIGNED

Elucidating the involvement of neutrophils in the pathogenesis of tuberculosis using a zebrafish model

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EC-Contrib. €

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Partnership

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 Outcomes and results

 MYCONEUTROPHILS project word cloud

Explore the words cloud of the MYCONEUTROPHILS project. It provides you a very rough idea of what is the project "MYCONEUTROPHILS" about.

combined    leader    continues    lines    function    pathogen    little    infectious    intensively    strategies    me    never    macrophages    macrophage    opportunity    immunology    multitude    health    lab    roles    gene    deeper    effectiveness    phagocytosis    unknown    gain    light    scientific    immunopathogenesis    mycobacterial    question    expression    act    techniques    thinking    biomedical    elucidation    kill    vivo    physical    experts    imaging    diseases    mutant    tuberculosis    questions    group    facilities    involvement    mycobacteria    absence    until    origin    marinum    unsurpassable    pathogenesis    neutrophils    career    recruitment    interaction    mycobacterium    limited    improvement    populations    neutrophil    humans    infection    interactions    host    implications    treatments    environment    urgent    huge    functionally    human    drug    play    resistant    zebrafish    disease    toll    scavengers    evade    afflicted    model    transgenic    played    indicate    shed   

Project "MYCONEUTROPHILS" data sheet

The following table provides information about the project.

Coordinator		 THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://www.med.cam.ac.uk/ramakrishnan/group-members/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

Map

 Project objective

Tuberculosis has afflicted humans for about 70,000 years and continues to take a huge toll on human health. The increase of drug-resistant Mycobacterium tuberculosis and the limited effectiveness of the existing treatments make urgent a deeper understanding of its immunopathogenesis. The role of macrophages in the disease has been intensively studied, but little is known about the involvement of neutrophils. Recent findings indicate that neutrophils play crucial roles in the pathogenesis of tuberculosis that are unknown until the present. Thus, in this project I will use the recognized zebrafish-Mycobacterium marinum infection model, available in the host lab, to study the role played by neutrophils in mycobacterial infection. I propose to use this infection model combined with in vivo imaging of the interactions host-pathogen, gain and loss of gene function strategies, the use of zebrafish transgenic and mutant lines, gene expression analysis, and multitude of other techniques available in the host lab to study (1) how mycobacteria can evade neutrophil recruitment and phagocytosis, (2) what is the origin of the two functionally different neutrophil populations observed in mycobacterial infection, (3) how neutrophils can kill mycobacteria in the absence of macrophages and without any physical interaction, and (4) why neutrophils act as macrophage scavengers. The elucidation of all these questions never studied before will allow me to shed light on the involvement of neutrophils in the pathogenesis of tuberculosis, and will represent a relevant improvement in the field with biomedical implications. Moreover, it will be a crucial step in my scientific career thinking of becoming a group leader in the field of immunology and infectious diseases, since I will have the opportunity to work in a relevant biomedical question, with the support of the main experts in the field, in an unsurpassable scientific environment, and with the best facilities.

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The information about "MYCONEUTROPHILS" are provided by the European Opendata Portal: CORDIS opendata.

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