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GROWTHPATTERN SIGNED

Coordination Of Patterning And Growth In The Spinal Cord

Total Cost €

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EC-Contrib. €

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Partnership

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Project "GROWTHPATTERN" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://kichevalab.com/home/erc-starting-grant
 Total cost 1˙499˙119 €
 EC max contribution 1˙499˙119 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙499˙119.00

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 Project objective

Individuals of the same species vary widely in size, but their organs have reproducible proportions and patterns of cell types. How cell fate specification and tissue growth are coordinated during embryonic development to achieve this reproducibility is a fundamental question in biology. Yet, surprisingly little is known about the underlying mechanisms. A major challenge has been to obtain the quantitative data required to assess the dynamics and variability in growth, pattern and signalling by morphogens – molecules that regulate both cell fate specification and tissue growth. I recently established experimental and theoretical approaches that allowed me to reconstruct with unprecedented resolution the three-dimensional growth and pattern of mouse and chick spinal cord. My data revealed a previously unanticipated role of tissue growth dynamics in controlling pattern reproducibility. This quantitative framework provides an exciting opportunity to elucidate the biophysical and molecular mechanisms of growth and pattern coordination. I will use this unique position to understand: 1) how signalling by multiple morphogens is integrated to control pattern, 2) how morphogens control cell cycle kinetics, 3) how morphogen source and target tissue are coupled to achieve pattern reproducibility. To address these issues, I will build on my experience with quantitative analyses to design novel assays where signalling, cell cycle dynamics and transcriptomes can be precisely measured and manipulated with single cell resolution. I will exploit state-of-the-art genome editing techniques to uncouple the critical feedback links and gain a novel perspective on pattern reproducibility and morphogen function. The project will advance our fundamental understanding of tissue morphogenesis and provide novel insights relevant to understanding information processing by signal transduction cascades, morphogen gradient activity, tissue engineering, and cancer biology.

 Publications

year authors and title journal last update
List of publications.
2017 Anna Kicheva, Nicolas C. Rivron
Creating to understand – developmental biology meets engineering in Paris
published pages: 733-736, ISSN: 0950-1991, DOI: 10.1242/dev.144915
Development 144/5 2020-03-20
2017 Marcin Zagorski, Yoji Tabata, Nathalie Brandenberg, Matthias P. Lutolf, Gašper Tkačik, Tobias Bollenbach, James Briscoe, Anna Kicheva
Decoding of position in the developing neural tube from antiparallel morphogen gradients
published pages: 1379-1383, ISSN: 0036-8075, DOI: 10.1126/science.aam5887
Science 356/6345 2020-03-20
2017 James Briscoe, Anna Kicheva
The physics of development 100 years after D\'Arcy Thompson\'s “On Growth and Form”
published pages: 26-31, ISSN: 0925-4773, DOI: 10.1016/j.mod.2017.03.005
Mechanisms of Development 145 2020-03-20
2018 Marketa Kaucka, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Eleni Kastriti, Meng Xie, Anna Kicheva, Karl Annusver, Maria Kasper, Orsolya Symmons, Leslie Pan, Francois Spitz, Jozef Kaiser, Maria Hovorakova, Tomas Zikmund, Kazunori Sunadome, Michael P Matise, Hui Wang, Ulrika Marklund, Hind Abdo, Patrik Ernfors, Pascal Maire, Maud Wurmser, Andrei S Chagin, Kaj Fried, Igor Adameyko
Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.34465
eLife 7 2020-03-20

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The information about "GROWTHPATTERN" are provided by the European Opendata Portal: CORDIS opendata.

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