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GSTHgNDD SIGNED

Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafish

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 GSTHgNDD project word cloud

Explore the words cloud of the GSTHgNDD project. It provides you a very rough idea of what is the project "GSTHgNDD" about.

demographic    interdisciplinary    spectrum    presented    career    dr    genetics    group    modifications    gst    medicine    altered    relationship    uses    biochemical    alleviation    environment    insult    phenotypes    personalized    childhood    dominant    generate    background    behavioural    interactions    aetiology    prevalence    metal    detection    markers    influence    communicable    embryos    population    training    epigenomic    genetic    conduct    heavy    integrate    model    risk    mercury    toxin    researcher    assessing    mental    brennan    serve    neurodevelopmental    relate    wild    transcriptomic    skills    quality    transferase    mutant    professional    later    gene    original    disease    ec    exposure    predictive    integrating    older    adverse    glutathione    developmental    zebrafish    collaborations    wellbeing    environmental    maturity    ages    diseases    predisposition    outcomes    crispr    individual    toxicity    respect    toxicology    leads    position    health    disorders   

Project "GSTHgNDD" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-20   to  2020-06-04

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Environmental factors, including the heavy metal mercury, are recognized as having a dominant influence on the aetiology and prevalence of neurodevelopmental behavioural disorders. This proposal will develop a new model for assessing the role of gene:environment interactions, specifically genetic predisposition for toxicity, in risk for disease, and identify early markers predictive of toxicity and later phenotypes. This will directly relate to the EC work program for Health, demographic change and wellbeing, with respect to both 'Personalized medicine' for non-communicable diseases and 'Early development' addressing mental health from childhood to older ages. The project uses the zebrafish model to investigate the relationship between glutathione-S-transferase (GST)-related genetic background, developmental exposure to mercury, and risk for neurodevelopmental disorders. This will be achieved by exposure of wild-type and CRISPR-generated Gst mutant embryos to mercury, and testing whether genetic predisposition leads to increased risk for toxin-induced behavioural phenotypes. We will test for altered biochemical, transcriptomic and epigenomic modifications that may serve as potential early markers for insult. The results obtained in this proposal will have significant impact on the ability to conduct individual and population specific toxicity risk assessment, and may lead to novel measures for early detection of increased risk and alleviation of potential adverse outcomes. The high-quality original research presented in the proposal will not only enable the Experienced Researcher to reach a position of professional maturity in her career, but will also allow her to develop a spectrum of new and interdisciplinary skills, integrating her previous training and knowledge into the behavioural genetics skills set. This project will also allow Dr. Brennan's group to integrate developmental toxicology into existing behavioural research, and will generate new collaborations.

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The information about "GSTHGNDD" are provided by the European Opendata Portal: CORDIS opendata.

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