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Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafish

Total Cost €


EC-Contrib. €






 GSTHgNDD project word cloud

Explore the words cloud of the GSTHgNDD project. It provides you a very rough idea of what is the project "GSTHgNDD" about.

prevalence    wellbeing    influence    career    dr    integrate    detection    training    health    environmental    childhood    embryos    presented    aetiology    brennan    communicable    serve    predisposition    markers    insult    older    adverse    exposure    genetic    toxicology    transferase    position    professional    researcher    relationship    diseases    alleviation    modifications    leads    phenotypes    toxicity    mental    altered    heavy    interdisciplinary    background    quality    assessing    biochemical    disease    toxin    mutant    maturity    original    gst    predictive    transcriptomic    integrating    uses    genetics    medicine    outcomes    environment    respect    mercury    conduct    metal    behavioural    ec    risk    model    relate    demographic    neurodevelopmental    spectrum    population    interactions    epigenomic    dominant    wild    glutathione    collaborations    developmental    zebrafish    later    skills    crispr    individual    disorders    ages    personalized    group    gene    generate   

Project "GSTHgNDD" data sheet

The following table provides information about the project.


Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-20   to  2020-06-04


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

Environmental factors, including the heavy metal mercury, are recognized as having a dominant influence on the aetiology and prevalence of neurodevelopmental behavioural disorders. This proposal will develop a new model for assessing the role of gene:environment interactions, specifically genetic predisposition for toxicity, in risk for disease, and identify early markers predictive of toxicity and later phenotypes. This will directly relate to the EC work program for Health, demographic change and wellbeing, with respect to both 'Personalized medicine' for non-communicable diseases and 'Early development' addressing mental health from childhood to older ages. The project uses the zebrafish model to investigate the relationship between glutathione-S-transferase (GST)-related genetic background, developmental exposure to mercury, and risk for neurodevelopmental disorders. This will be achieved by exposure of wild-type and CRISPR-generated Gst mutant embryos to mercury, and testing whether genetic predisposition leads to increased risk for toxin-induced behavioural phenotypes. We will test for altered biochemical, transcriptomic and epigenomic modifications that may serve as potential early markers for insult. The results obtained in this proposal will have significant impact on the ability to conduct individual and population specific toxicity risk assessment, and may lead to novel measures for early detection of increased risk and alleviation of potential adverse outcomes. The high-quality original research presented in the proposal will not only enable the Experienced Researcher to reach a position of professional maturity in her career, but will also allow her to develop a spectrum of new and interdisciplinary skills, integrating her previous training and knowledge into the behavioural genetics skills set. This project will also allow Dr. Brennan's group to integrate developmental toxicology into existing behavioural research, and will generate new collaborations.

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The information about "GSTHGNDD" are provided by the European Opendata Portal: CORDIS opendata.

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