Explore the words cloud of the HIGH-GEAR project. It provides you a very rough idea of what is the project "HIGH-GEAR" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||1˙968˙375 €|
|EC max contribution||1˙968˙375 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-06-01 to 2022-05-31|
Take a look of project's partnership.
|1||STOCKHOLMS UNIVERSITET||SE (STOCKHOLM)||coordinator||1˙968˙375.00|
It is estimated that almost half of all enzymes utilize metal cofactors for their function, for example the respiratory complexes and the oxygen-evolving photosystem II, the most fundamental requirements for aerobic life as we know it. If we could mimic nature’s use of metals for harvesting sunlight, energy conversion and chemical synthesis it would eliminate the need for fossil fuels and greatly increase the possibilities of chemical industry while reducing the environmental impact. Achieving this type of chemistry is an outstanding testament to evolution and understanding it is a glaring challenge to mankind.
These types of reactions are based on very challenging redox chemistry (involving one or several electrons). The key catalytic species are generally high-valent metal clusters with a varying ligand environment, provided by the protein and other bound molecules, that directly controls the reactivity of the inorganic core. To be able to understand and mimic this chemistry it is of central importance to know the geometric and electronic structures of the metal core as well as the entire ligand environment for these usually short-lived and very reactive intermediates. It has, for a number of reasons, proven extremely challenging to obtain these for protein-coordinated catalysts.
The central goal of this project is to determine true and accurate geometric and electronic structures of high-valent di-nuclear Fe/Fe and Mn/Fe metal sites coordinated in protein matrices known to direct these for varied and important chemistry. By combining new X-ray diffraction based techniques with advanced spectroscopy we aim to define how the protein controls the entatic state as well as reactivity and mechanism for some of the most potent catalysts in nature. The results will serve as a basis for design of oxygen-activating catalysts with novel properties.
|year||authors and title||journal||last update|
Yury Kutin, Ramona Kositzki, Rui M. M. Branca, Vivek Srinivas, Daniel Lundin, Michael Haumann, Martin HÃ¶gbom, Nicholas Cox, Julia J. Griese
Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins
published pages: 18372-18386, ISSN: 0021-9258, DOI: 10.1074/jbc.ra119.010570
|Journal of Biological Chemistry 294/48||2020-01-28|
Stefan Mebs, Vivek Srinivas, Ramona Kositzki, Julia J. Griese, Martin HÃ¶gbom, Michael Haumann
Fate of oxygen species from O2 activation at dimetal cofactors in an oxidase enzyme revealed by 57Fe nuclear resonance X-ray scattering and quantum chemistry
published pages: 148060, ISSN: 0005-2728, DOI: 10.1016/j.bbabio.2019.148060
|Biochimica et Biophysica Acta (BBA) - Bioenergetics 1860/12||2020-01-28|
Julia J. Griese, Ramona Kositzki, Michael Haumann, Martin HÃ¶gbom
Assembly of a heterodinuclear Mn/Fe cofactor is coupled to tyrosineâ€“valine ether cross-link formation in the R2-like ligand-binding oxidase
published pages: 211-221, ISSN: 0949-8257, DOI: 10.1007/s00775-019-01639-4
|JBIC Journal of Biological Inorganic Chemistry 24/2||2020-01-28|
Julia J. Griese, Martin HÃ¶gbom
Location-specific quantification of protein-bound metal ions by X-ray anomalous dispersion: Q-XAD
published pages: 764-771, ISSN: 2059-7983, DOI: 10.1107/s2059798319009926
|Acta Crystallographica Section D Structural Biology 75/8||2020-01-28|
Hongyi Xu, Hugo Lebrette, Max T. B. Clabbers, Jingjing Zhao, Julia J. Griese, Xiaodong Zou, Martin HÃ¶gbom
Solving a new R2lox protein structure by microcrystal electron diffraction
published pages: eaax4621, ISSN: 2375-2548, DOI: 10.1126/sciadv.aax4621
|Science Advances 5/8||2020-01-28|
KristÄ«ne GrÄve, Wietske Lambert, Gustav Berggren, Julia J. Griese, Matthew D. Bennett, Derek T. Logan, Martin HÃ¶gbom
Redox-induced structural changes in the di-iron and di-manganese forms of Bacillus anthracis ribonucleotide reductase subunit NrdF suggest a mechanism for gating of radical access
published pages: 849-861, ISSN: 0949-8257, DOI: 10.1007/s00775-019-01703-z
|JBIC Journal of Biological Inorganic Chemistry 24/6||2020-01-28|
Vivek Srinivas, Hugo Lebrette, Daniel Lundin, Yuri Kutin, Margareta Sahlin, Michael Lerche, JÃ¼rgen Eirich, Rui M. M. Branca, Nicholas Cox, Britt-Marie SjÃ¶berg, Martin HÃ¶gbom
Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens
published pages: 416-420, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0653-6
Pearson T. Maugeri, Julia J. Griese, Rui M. Branca, Effie K. Miller, Zachary R. Smith, JÃ¼rgen Eirich, Martin HÃ¶gbom, Hannah S. Shafaat
Driving Protein Conformational Changes with Light: Photoinduced Structural Rearrangement in a Heterobimetallic Oxidase
published pages: 1471-1480, ISSN: 0002-7863, DOI: 10.1021/jacs.7b11966
|Journal of the American Chemical Society 140/4||2019-05-14|
Julia J. Griese, Rui M. M. Branca, Vivek Srinivas, Martin HÃ¶gbom
Ether cross-link formation in the R2-like ligand-binding oxidase
published pages: 879-886, ISSN: 0949-8257, DOI: 10.1007/s00775-018-1583-3
|JBIC Journal of Biological Inorganic Chemistry 23/6||2019-05-14|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HIGH-GEAR" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "HIGH-GEAR" are provided by the European Opendata Portal: CORDIS opendata.
Learning from social scents: from territory to identityRead More
Comprehensive anatomical, genetic and functional identification of cerebellar nuclei neurons and their roles in sensorimotor tasksRead More
High throughput multiplexed trace-analyte screening for diagnostics applicationsRead More