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CureTheCloves SIGNED

PIK3CA inhibition in patients with the CLOVES syndrome

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "CureTheCloves" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PARIS DESCARTES 

Organization address
address: RUE DE L ECOLE DE MEDECINE 12
city: PARIS CEDEX 06
postcode: 75270
website: www.univ-paris5.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 148˙750 €
 EC max contribution 148˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2018-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE PARIS DESCARTES FR (PARIS CEDEX 06) coordinator 148˙750.00

Map

 Project objective

The Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Scoliosis/Skeletal and Spinal (CLOVES) syndrome is a genetic disorder due to a gain of function mutation of the PIK3CA in a mosaic fashion. This rare condition is associated with severe deformation and poor survival. We identified a new drug able to dramatically improve the outcome of patients with this rare disease. The purpose of the Proof of Concept grant is to better understand the molecular effect of this drug and to rapidly accede to Orphan drug designation.

 Publications

year authors and title journal last update
List of publications.
2018 Quitterie Venot, Thomas Blanc, Smail Hadj Rabia, Laureline Berteloot, Sophia Ladraa, Jean-Paul Duong, Estelle Blanc, Simon C. Johnson, Clément Hoguin, Olivia Boccara, Sabine Sarnacki, Nathalie Boddaert, Stephanie Pannier, Frank Martinez, Sato Magassa, Junna Yamaguchi, Bertrand Knebelmann, Pierre Merville, Nicolas Grenier, Dominique Joly, Valérie Cormier-Daire, Caroline Michot, Christine Bole-Feysot, Arnaud Picard, Véronique Soupre, Stanislas Lyonnet, Jeremy Sadoine, Lotfi Slimani, Catherine Chaussain, Cécile Laroche-Raynaud, Laurent Guibaud, Christine Broissand, Jeanne Amiel, Christophe Legendre, Fabiola Terzi, Guillaume Canaud
Targeted therapy in patients with PIK3CA-related overgrowth syndrome
published pages: 540-546, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0217-9
Nature 558/7711 2019-06-11

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The information about "CURETHECLOVES" are provided by the European Opendata Portal: CORDIS opendata.

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