Explore the words cloud of the MEME project. It provides you a very rough idea of what is the project "MEME" about.
The following table provides information about the project.
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
|Coordinator Country||Ireland [IE]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-02-01 to 2022-01-31|
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|1||THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN||IE (DUBLIN)||coordinator||1˙500˙000.00|
The goal of this project is to understand how specific memory engrams are physically stored in the brain. Connectionist theories of memory storage have guided research into the neuroscience of memory for over a half century, but have received little direct proof due to experimental limitations. The major confound that has limited direct testing of such theories has been an inability to identify the cells and circuits that store specific memories. Memory engram technology, which allows the tagging and in vivo manipulation of specific engram cells, has recently allowed us to overcome this empirical limitation and has revolutionised the way memory can be studied in rodent models. Based on our research it is now known that sparse populations of hippocampal neurons that were active during a defined learning experience are both sufficient and necessary for retrieval of specific contextual memories. More recently we have established that hippocampal engram cells preferentially synapse directly onto postsynaptic engram cells. This “engram cell connectivity” could provide the neurobiological substrate for the storage of multimodal memories through a distributed engram circuit. However it is currently unknown whether engram cell connectivity itself is important for memory function. The proposed integrative neuroscience project will employ inter-disciplinary methods to directly probe the importance of engram cell connectivity for memory retrieval, storage, and encoding. The outcomes will directly inform a novel and comprehensive neurobiological model of memory engram storage.
|year||authors and title||journal||last update|
Michele Pignatelli, TomÃ¡s J. Ryan, Dheeraj S. Roy, Chanel Lovett, Lillian M. Smith, Shruti Muralidhar, Susumu Tonegawa
Engram Cell Excitability State Determines the Efficacy of Memory Retrieval
published pages: 274-284.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.11.029
Clara Ortega-de San Luis, TomÃ¡s J. Ryan
United states of amnesia: rescuing memory loss from diverse conditions
published pages: dmm035055, ISSN: 1754-8403, DOI: 10.1242/dmm.035055
|Disease Models & Mechanisms 11/5||2019-10-08|
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