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BioMPCat TERMINATED

Bioorthogonal Metal-Peptide Catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BioMPCat project word cloud

Explore the words cloud of the BioMPCat project. It provides you a very rough idea of what is the project "BioMPCat" about.

unprecedented    catalytic    efficiency    overcoming    biochemistry    catalyst    stability    modest    tuned    interface    biocompatibility    cell    alkyne    complexes    functional    render    physiological    medicinal    transformation    reactivity    profound    peptides    limited    designed    site    reactions    transformations    metals    remarkable    metal    biomolecules    drug    combinatorial    occurring    cellular    had    suited    structural    cleavage    zn    chemistry    cu    avenues    therapeutics    proteins    naturally    selectivity    environment    optimal    establishing    structures    native    ideally    perspectives    limitations    selective    toxic    hydrolytically    biology    class    biotechnology    identification    biocompatible    rate    peptide    imaging    active    display    catalysts    bioorthogonal    chemical    hindered    powerful    compatible    biompcat    catalysis    herein    opened    azide    assays    ligands    inherent    diversity    investigations    reaction    rationally    cycloaddition    ligations   

Project "BioMPCat" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.wennemers.ethz.ch/
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 175˙419.00

Map

 Project objective

In recent years, the development of bioorthogonal reactions has had a profound impact on several research areas such as imaging, drug development, biochemistry, and biotechnology. However, further advances in this topic are hindered by the limited number of biocompatible chemical transformations and by their rather modest reaction rate. BioMPCat (Bioorthogonal Metal-Peptide Catalysis) aims at overcoming the current limitations by establishing metal-peptide complexes as a novel and powerful class of bioorthogonal catalysts capable of promoting unprecedented transformations with remarkable efficiency under physiological conditions. Naturally occurring peptides are ideally suited ligands for metals and, due to the inherent large structural and functional diversity, the chemical properties of their metal-complexes can be tuned to display optimal catalytic features: reactivity, selectivity, stability, and biocompatibility. Using simple and rationally designed combinatorial assays, the BioMPCat project will allow the identification of lead catalysts structures for biomolecules ligations as well as for site-selective cleavage of native proteins. The novel catalytic concepts will be established by: (1) identifying a non-toxic and highly effective Cu-peptide catalyst for the alkyne-azide cycloaddition reaction, which could render such important transformation compatible with the cellular environment; (2) developing a general approach to site-selective cleavage of native proteins based on the identification of a hydrolytically-active Zn-peptide complex. The research proposed herein will allow unprecedented investigations at the interface between chemistry and biology: new perspectives in biochemistry and cell biology will be opened, as well as novel avenues in medicinal chemistry and therapeutics.

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The information about "BIOMPCAT" are provided by the European Opendata Portal: CORDIS opendata.

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