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BioMPCat TERMINATED

Bioorthogonal Metal-Peptide Catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BioMPCat project word cloud

Explore the words cloud of the BioMPCat project. It provides you a very rough idea of what is the project "BioMPCat" about.

metal    stability    rationally    biochemistry    combinatorial    establishing    toxic    ligands    structural    occurring    reaction    naturally    ideally    zn    cellular    catalyst    imaging    display    structures    cycloaddition    rate    render    class    efficiency    catalytic    interface    suited    profound    functional    biocompatibility    environment    hydrolytically    biology    biompcat    ligations    azide    metals    physiological    overcoming    cu    bioorthogonal    remarkable    investigations    inherent    peptides    biomolecules    assays    compatible    reactivity    complexes    medicinal    site    cell    powerful    transformation    selective    proteins    cleavage    reactions    unprecedented    hindered    catalysts    limitations    peptide    modest    avenues    optimal    alkyne    identification    perspectives    opened    limited    chemical    transformations    diversity    chemistry    had    biocompatible    herein    designed    biotechnology    native    active    tuned    selectivity    drug    catalysis    therapeutics   

Project "BioMPCat" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.wennemers.ethz.ch/
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 175˙419.00

Map

 Project objective

In recent years, the development of bioorthogonal reactions has had a profound impact on several research areas such as imaging, drug development, biochemistry, and biotechnology. However, further advances in this topic are hindered by the limited number of biocompatible chemical transformations and by their rather modest reaction rate. BioMPCat (Bioorthogonal Metal-Peptide Catalysis) aims at overcoming the current limitations by establishing metal-peptide complexes as a novel and powerful class of bioorthogonal catalysts capable of promoting unprecedented transformations with remarkable efficiency under physiological conditions. Naturally occurring peptides are ideally suited ligands for metals and, due to the inherent large structural and functional diversity, the chemical properties of their metal-complexes can be tuned to display optimal catalytic features: reactivity, selectivity, stability, and biocompatibility. Using simple and rationally designed combinatorial assays, the BioMPCat project will allow the identification of lead catalysts structures for biomolecules ligations as well as for site-selective cleavage of native proteins. The novel catalytic concepts will be established by: (1) identifying a non-toxic and highly effective Cu-peptide catalyst for the alkyne-azide cycloaddition reaction, which could render such important transformation compatible with the cellular environment; (2) developing a general approach to site-selective cleavage of native proteins based on the identification of a hydrolytically-active Zn-peptide complex. The research proposed herein will allow unprecedented investigations at the interface between chemistry and biology: new perspectives in biochemistry and cell biology will be opened, as well as novel avenues in medicinal chemistry and therapeutics.

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The information about "BIOMPCAT" are provided by the European Opendata Portal: CORDIS opendata.

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