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BioMPCat TERMINATED

Bioorthogonal Metal-Peptide Catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BioMPCat project word cloud

Explore the words cloud of the BioMPCat project. It provides you a very rough idea of what is the project "BioMPCat" about.

therapeutics    structural    metal    identification    peptides    functional    zn    suited    toxic    modest    interface    render    had    compatible    metals    peptide    site    perspectives    tuned    avenues    limitations    herein    combinatorial    complexes    cycloaddition    optimal    bioorthogonal    profound    biocompatible    inherent    opened    efficiency    catalytic    chemistry    biotechnology    biomolecules    diversity    hindered    environment    limited    physiological    azide    native    selectivity    occurring    biompcat    reactions    medicinal    biochemistry    display    naturally    powerful    ligands    rationally    active    cu    cellular    alkyne    remarkable    catalysis    designed    class    proteins    investigations    stability    cleavage    selective    overcoming    cell    rate    biocompatibility    biology    reaction    chemical    unprecedented    catalysts    reactivity    assays    ligations    transformation    imaging    establishing    structures    transformations    ideally    catalyst    drug    hydrolytically   

Project "BioMPCat" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.wennemers.ethz.ch/
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 175˙419.00

Map

 Project objective

In recent years, the development of bioorthogonal reactions has had a profound impact on several research areas such as imaging, drug development, biochemistry, and biotechnology. However, further advances in this topic are hindered by the limited number of biocompatible chemical transformations and by their rather modest reaction rate. BioMPCat (Bioorthogonal Metal-Peptide Catalysis) aims at overcoming the current limitations by establishing metal-peptide complexes as a novel and powerful class of bioorthogonal catalysts capable of promoting unprecedented transformations with remarkable efficiency under physiological conditions. Naturally occurring peptides are ideally suited ligands for metals and, due to the inherent large structural and functional diversity, the chemical properties of their metal-complexes can be tuned to display optimal catalytic features: reactivity, selectivity, stability, and biocompatibility. Using simple and rationally designed combinatorial assays, the BioMPCat project will allow the identification of lead catalysts structures for biomolecules ligations as well as for site-selective cleavage of native proteins. The novel catalytic concepts will be established by: (1) identifying a non-toxic and highly effective Cu-peptide catalyst for the alkyne-azide cycloaddition reaction, which could render such important transformation compatible with the cellular environment; (2) developing a general approach to site-selective cleavage of native proteins based on the identification of a hydrolytically-active Zn-peptide complex. The research proposed herein will allow unprecedented investigations at the interface between chemistry and biology: new perspectives in biochemistry and cell biology will be opened, as well as novel avenues in medicinal chemistry and therapeutics.

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The information about "BIOMPCAT" are provided by the European Opendata Portal: CORDIS opendata.

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