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DMC-MALVEC SIGNED

Automated diagnostic platform, data management system and innovative communication tool, for improving the impact of malaria vector control interventions

Total Cost €

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EC-Contrib. €

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Partnership

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Project "DMC-MALVEC" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.dmc-malvec.eu/
 Total cost 3˙167˙376 €
 EC max contribution 2˙768˙001 € (87%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2015
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 552˙066.00
2    LIVERPOOL SCHOOL OF TROPICAL MEDICINE UK (LIVERPOOL) participant 505˙355.00
3    HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. DE (Villingen) participant 403˙568.00
4    MINISTRY OF HEALTH ZM (LUSAKA) participant 267˙523.00
5    Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale CM (Yaounde) participant 267˙500.00
6    JIMMA UNIVERSITY ET (JIMMA) participant 264˙598.00
7    FAST TRACK DIAGNOSTICS LUXEMBOURG SARL LU (ESCH SUR ALZETTE) participant 251˙000.00
8    N.T. LABORATORY SRL IT (CALENZANO) participant 213˙888.00
9    GEOPONIKO PANEPISTIMION ATHINON EL (ATHINA) participant 42˙500.00
10    SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT CH (Basel) participant 0.00

Map

 Project objective

Malaria is a life-threatening disease causing more than 500,000 deaths every year in sub-Saharan Africa. Prevention of the disease is best achieved by vector control which relies on the use of insecticides. Monitoring mosquito vector populations is an integral component of control programmes and a prerequisite for effective interventions. Several individual methods are used for this task, However, there are obstacles to their uptake, as well as challenges in organizing, interpreting and communicating vector control data. We will develop a fully integrated and automated multiplex vector-diagnostic platform (LabDisk) for monitoring the species ID, the infection status of mosquitoes and the insecticide resistance profile of malaria vector populations. The system will provide sample-to-answer determinations, and it will perform genotyping at substantially lower cost, compared to the assays that are currently used in Africa. The LabDisk will be interfaced with a Disease Data Management System (DDMS), custom made data management software which will collect data from routine entomological monitoring activities, store, and make available stratified information based on “user queries” in a standardized way. The “GAME”, a modern ICT platform that employs interactive ways of communicating guidelines and exemplifying good practices of successful use of interventions in the health sector will be also employed, to teach operational end users the use of data to make informed decisions. The integrated system (LabDisk, DDMS & Game) will be implemented in four sub-Saharan African countries, highly representative of malaria settings and vector control problems, to support informed decision-making about vector control and disease management. It will cover the urgent needs of an existing “market” and will provide solution to end users, to address a most important societal challenge in Africa, the control of malaria. The system has a vast expansion potential in other applications.

 Deliverables

List of deliverables.
Periodic report 1 Documents, reports 2020-03-17 11:53:55
Report on fluidic layouts Documents, reports 2020-03-17 11:53:55
Second Report on communication activities Documents, reports 2020-03-17 11:53:55
Validated GAME available for pilot implementation Demonstrators, pilots, prototypes 2020-03-17 11:53:55
Second Annual plan for dissemination of information/knowledge and external communication Documents, reports 2020-03-17 11:53:55
Third Annual newsletter Websites, patent fillings, videos etc. 2020-03-17 11:53:55
Demo of LabDisk operation at lab scale Demonstrators, pilots, prototypes 2020-03-17 11:53:55
DDMS configured and validated in Cameroon for collation of historical entomology data Demonstrators, pilots, prototypes 2020-03-17 11:53:55
Report of lab testing of systems diagnostic performance Documents, reports 2020-03-17 11:53:55
Second Annual newsletter Websites, patent fillings, videos etc. 2020-03-17 11:53:55
Report on NA assay protocol (extraction and amplification) Documents, reports 2020-03-17 11:53:54
TaqMan kits and lyophilised components are manufactured and delivered to partners Other 2020-03-17 11:53:54
Exploitation Plan Documents, reports 2020-03-17 11:53:54
First Annual newsletter Websites, patent fillings, videos etc. 2020-03-17 11:53:55
Adapted and expanded GAME Other 2020-03-17 11:53:54
Project website to support networking and information exchange Websites, patent fillings, videos etc. 2020-03-17 11:53:55
Risk management plan Documents, reports 2020-03-17 11:53:54
First Report on communication activities Documents, reports 2020-03-17 11:53:54
Documented baseline information for the DDMS and GAME requirements Documents, reports 2020-03-17 11:53:55
First Annual plan for dissemination Documents, reports 2020-03-17 11:53:54
DDMS adapted to cater for gene expression data and analysis of pools of mosquito data Other 2020-03-17 11:53:54
Agenda of the Startup meeting Documents, reports 2020-03-17 11:53:54
Quality control handbook Documents, reports 2020-03-17 11:53:55

Take a look to the deliverables list in detail:  detailed list of DMC-MALVEC deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Konstantinos Mitsakakis, Sebastian Hin, Pie Müller, Nadja Wipf, Edward Thomsen, Michael Coleman, Roland Zengerle, John Vontas, Konstantinos Mavridis
Converging Human and Malaria Vector Diagnostics with Data Management towards an Integrated Holistic One Health Approach
published pages: 259, ISSN: 1660-4601, DOI: 10.3390/ijerph15020259
International Journal of Environmental Research and Public Health 15/2 2020-03-17
2018 Mary Kefi, Konstantinos Mavridis, Maria L. Simões, George Dimopoulos, Inga Siden-Kiamos, John Vontas
New rapid one-step PCR diagnostic assay for Plasmodium falciparum infective mosquitoes
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-19780-6
Scientific Reports 8/1 2020-03-17
2019 Konstantinos Mavridis, Nadja Wipf, Sandrine Medves, Ignacio Erquiaga, Pie Müller, John Vontas
Rapid multiplex gene expression assays for monitoring metabolic resistance in the major malaria vector Anopheles gambiae
published pages: , ISSN: 1756-3305, DOI: 10.1186/s13071-018-3253-2
Parasites & Vectors 12/1 2020-03-17
2018 Konstantinos Mavridis, Nadja Wipf, Pie Müller, Mohamed M. Traoré, Gunter Muller, John Vontas
Detection and Monitoring of Insecticide Resistance Mutations in Anopheles gambiae: Individual vs Pooled Specimens
published pages: 479, ISSN: 2073-4425, DOI: 10.3390/genes9100479
Genes 9/10 2020-03-17

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