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SmartHeart SIGNED

SmartHeart, a 3D in vitro assay for improved assessment of cardiac drug efficacy and toxicity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SmartHeart project word cloud

Explore the words cloud of the SmartHeart project. It provides you a very rough idea of what is the project "SmartHeart" about.

er    limiting    imaging    action    entering    retrieve    standards    4dcell    feedback    animal    read    drug    cros    culture    minimized    efficient    commercial    cardiomyocytes    qualitative    academic    simultaneously    cellular    specifications    drugs    maturation    body    sub       angle    platforms    clinical    commercialized    device    hcs    microstructured    screening    cardiac    mimic    hts    structure    3dcell    acquired    ultimate    assay    final    quantitative    pluripotent    proprietary    pharma    nature    plates    diseases    stage    techniques    technological    vitro    smartheart    transients    compatible    stem    fine    currently    resolution    leader    3d    gel    cultured    physics    candidate    managerial    models    cms    answer    multiwell    trials    career    act    cells    assays    put    meet    maturity    shortcomings    closer    expertise    contractility    industrial    predict    whom    ethical    tune    outs    observation    human    calcium    competences   

Project "SmartHeart" data sheet

The following table provides information about the project.

Coordinator
4DCELL 

Organization address
address: 14 RUE DE LA BEAUNE BAT C ETAGE 2
city: MONTREUIL
postcode: 93100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-02   to  2022-03-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    4DCELL FR (MONTREUIL) coordinator 196˙707.00

Map

 Project objective

Currently, animal models are still widely used in the pre-clinical stage of drug development to mimic human diseases or predict the human body’s response to candidate drugs. However, their use should be minimized as much as possible due to ethical issues and since only 9.6% of drugs entering phase I of clinical trials end up being commercialized. Therefore, the goal of this action is to develop a novel proprietary 3D in vitro cardiac assay. The SmartHeart will retrieve several of the most important read-outs commonly assessed to study the impact of drugs at the cardiac level in the pre-clinical phase. The all in one assay will be based on a microstructured gel where cardiac cells, as cardiomyocytes derived from induced pluripotent stem cells will be cultured. The SmartHeart will answer to the shortcomings of academic and commercial available in vitro assays, by enabling the qualitative and quantitative measurement of several parameters, as contractility and Calcium transients. Simultaneously, the assay will enable sub-cellular structure observation via high-resolution imaging techniques. Furthermore, the 3D nature of the assay will contribute to the efficient maturation of the induced CMs, which is still a limiting factor when not using cardiac human cells, but rather induced CMs, in in vitro assays. The ultimate aim of the project is to make this device available to screening platforms, e.g. Pharma or CROs. The technology will be implemented in multiwell plates compatible with the standards of HTS/HCS and will be available to early-users, from whom feedback will be acquired, enabling to fine tune the specifications of the final device. This project will meet the best of the ER competences in physics, with the expertise of 4Dcell in 3Dcell culture systems. With this project, the ER will reach a level of maturity on several technological, managerial and industrial aspects providing her a new career angle and put her a step closer to act as a leader in research.

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The information about "SMARTHEART" are provided by the European Opendata Portal: CORDIS opendata.

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