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SmartHeart SIGNED

SmartHeart, a 3D in vitro assay for improved assessment of cardiac drug efficacy and toxicity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SmartHeart project word cloud

Explore the words cloud of the SmartHeart project. It provides you a very rough idea of what is the project "SmartHeart" about.

trials    human    read    pluripotent    plates    standards    microstructured    feedback       industrial    sub    entering    expertise    hcs    commercialized    cultured    qualitative    cms    assay    culture    screening    resolution    hts    leader    er    calcium    cardiomyocytes    assays    multiwell    competences    stem    ethical    models    predict    commercial    academic    angle    cells    cardiac    act    observation    retrieve    action    pharma    managerial    quantitative    meet    drugs    body    cellular    stage    clinical    device    animal    final    fine    compatible    limiting    cros    shortcomings    nature    imaging    whom    tune    3dcell    techniques    answer    diseases    maturity    specifications    mimic    gel    physics    vitro    ultimate    3d    proprietary    acquired    structure    candidate    put    outs    drug    contractility    simultaneously    efficient    4dcell    platforms    transients    technological    career    maturation    minimized    smartheart    currently    closer   

Project "SmartHeart" data sheet

The following table provides information about the project.

Coordinator
4DCELL 

Organization address
address: 14 RUE DE LA BEAUNE BAT C ETAGE 2
city: MONTREUIL
postcode: 93100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 196˙707 €
 EC max contribution 196˙707 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2020
 Duration (year-month-day) from 2020-03-02   to  2022-03-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    4DCELL FR (MONTREUIL) coordinator 196˙707.00

Map

 Project objective

Currently, animal models are still widely used in the pre-clinical stage of drug development to mimic human diseases or predict the human body’s response to candidate drugs. However, their use should be minimized as much as possible due to ethical issues and since only 9.6% of drugs entering phase I of clinical trials end up being commercialized. Therefore, the goal of this action is to develop a novel proprietary 3D in vitro cardiac assay. The SmartHeart will retrieve several of the most important read-outs commonly assessed to study the impact of drugs at the cardiac level in the pre-clinical phase. The all in one assay will be based on a microstructured gel where cardiac cells, as cardiomyocytes derived from induced pluripotent stem cells will be cultured. The SmartHeart will answer to the shortcomings of academic and commercial available in vitro assays, by enabling the qualitative and quantitative measurement of several parameters, as contractility and Calcium transients. Simultaneously, the assay will enable sub-cellular structure observation via high-resolution imaging techniques. Furthermore, the 3D nature of the assay will contribute to the efficient maturation of the induced CMs, which is still a limiting factor when not using cardiac human cells, but rather induced CMs, in in vitro assays. The ultimate aim of the project is to make this device available to screening platforms, e.g. Pharma or CROs. The technology will be implemented in multiwell plates compatible with the standards of HTS/HCS and will be available to early-users, from whom feedback will be acquired, enabling to fine tune the specifications of the final device. This project will meet the best of the ER competences in physics, with the expertise of 4Dcell in 3Dcell culture systems. With this project, the ER will reach a level of maturity on several technological, managerial and industrial aspects providing her a new career angle and put her a step closer to act as a leader in research.

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The information about "SMARTHEART" are provided by the European Opendata Portal: CORDIS opendata.

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