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ChiPyrNMR

Better tools for combating insect borne diseases by understanding influences on the fate of common pesticides in paint formulations

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ChiPyrNMR project word cloud

Explore the words cloud of the ChiPyrNMR project. It provides you a very rough idea of what is the project "ChiPyrNMR" about.

quantifying    multidisciplinary    dosing    occurrence    formulation    adjusted    validate    insecticidal    humans    insecticides    gained    constitutes    interaction    centers    virus    innovative    risk    individual    prevention    behavior    malaria    advantage    deployment    organisation    little    spread    enantiomers    critical    photo    protection    mosquitoes    generate    fever    once    mosquito    tools    stability    environment    health    trial    exists    contact    fate    powerful    chemical    pyrethroids    chiral    nature    matrices    significantly    biological    ingredient    invasive    mechanisms    minimize    exploited    yellow    solutions    accurately    compounds    zika    insects    collateral    suffer    diseases    avoiding    composition    situ    paint    laboratory    extraction    potentially    tracking    nmr    spectroscopy    active    reduce    public    recommended    hydrolysis    configuration    either    preparation    enantiomeric    damage    degradation    formulations    performed    clear    safer    world    dengue    phenomena    determined    kinetic    vaccines    transmitted   

Project "ChiPyrNMR" data sheet

The following table provides information about the project.

Coordinator
NOURYON CHEMICALS B.V. 

Organization address
address: VELPERWEG 76
city: ARNHEM
postcode: 6824 BM
website: www.akzonobel.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NOURYON CHEMICALS B.V. NL (ARNHEM) coordinator 165˙598.00

Map

 Project objective

Malaria, Zika virus, dengue fever and yellow fever are mosquito transmitted diseases for which a vaccines either do not exists or are not widely available. Prevention control is the main way to reduce their spread, and the use of insecticides constitutes one of the key measures recommended by World Health Organisation. New innovative methods of bringing the insects into contact with the insecticides include the development of insecticidal paint with the advantage of safer application, targeted dosing and significantly reduced risk of collateral damage to humans and the environment. This project will address some of the challenges in developing these solutions. Pyrethroids are one of the best insecticides for public health use but suffer from hydrolysis and photo-degradation. Little is known about how their application in paint formulations affects this behavior. At a chemical level the biological activity of the individual enantiomers is determined by the configuration of their chiral centers, so accurately quantifying the enantiomeric composition is critical to tracking potential degradation. The aim of this project is to generate robust methods for a better understanding of the fate of insecticides in complex matrices like paint. Once the nature of the degradation products and the related mechanisms is clear, the formulation can be adjusted to minimize the occurrence of degradation or enhance active ingredient protection. The kinetic analysis of the degradation processes and the interaction/stability studies are best performed in-situ avoiding potentially invasive extraction sample preparation steps, so the powerful tools of advanced NMR spectroscopy will be exploited to characterize these phenomena. The knowledge gained will be used to validate/explain multidisciplinary laboratory biological trial results on mosquitoes and be able to be exploited more widely to other systems and support the research into other compounds for potential deployment in this way.

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The information about "CHIPYRNMR" are provided by the European Opendata Portal: CORDIS opendata.

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