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SARCOM SIGNED

Selection for antimicrobial resistance in a complex community context

Total Cost €

0

EC-Contrib. €

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Partnership

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Project "SARCOM" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 183˙454.00

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 Project objective

Increased antibiotic resistance (AMR) in a wide range of human pathogens is a growing public health threat, and the World Health Organization (WHO) forecasts a post-antibiotic era for the 21st century (WHO, 2014). The evolution of AMR in bacteria is determined by both the acquisition of resistance through horizontal gene transfer or chromosomal mutation and by the way resistance affects the competitive ability of a microbe in the presence and absence of antibiotics.

The majority of research on selection for AMR to date has focused on detailed in vitro studies of selection for AMR in specific bacterial clones. More significantly, no studies to date have explicitly investigated the implication of being embedded in a complex community for the evolution of AMR. Therefore, in the proposed research I aim to use a multidisciplinary approach by for the first time combining the precision of in vitro experimental evolution experiments with the high resolution of molecular biology to study the evolution and spread of AMR in complex community contexts.

The proposed project will allow me to complement my strong background in molecular biology and microbial ecology with evolutionary microbiology and novel bioinformatic approaches. Being situated in one of the most prominent microbial ecology and evolution laboratories worldwide, based at the Biosciences Department at the University of Exeter will be crucial for my personal development in becoming an independent European researcher. The University of Exeter provides an EU accredited program for academic training and personal career development.

The proposed research will moreover provide ample opportunities to instigate and be involved in internal and international collaboration with world-leading researchers in diverse research fields. Furthermore, I aim to raise public awareness to the threat AMR bacteria possess to human health and involve the public in mitigation strategies to avoid the spread of AMR genes.

 Publications

year authors and title journal last update
List of publications.
2019 Michiel Vos, Louise Sibleyras, Lai Ka Lo, Elze Hesse, William H Gaze, Uli Klümper
Zinc can counteract selection for ciprofloxacin resistance
published pages: 780981, ISSN: , DOI:
bioRxiv 2020-02-05
2018 Maria Arias-Andres, Uli Klümper, Keilor Rojas-Jimenez, Hans-Peter Grossart
Microplastic pollution increases gene exchange in aquatic ecosystems
published pages: 253-261, ISSN: 0269-7491, DOI: 10.1016/j.envpol.2018.02.058
Environmental Pollution 237 2020-02-05
2019 Uli Klümper, Mario Recker, Lihong Zhang, Xiaole Yin, Tong Zhang, Angus Buckling, William H. Gaze
Selection for antimicrobial resistance is reduced when embedded in a natural microbial community
published pages: 2927-2937, ISSN: 1751-7362, DOI: 10.1038/s41396-019-0483-z
The ISME Journal 13/12 2020-02-05
2019 Uli Klümper, Arnaud Maillard, Elze Hesse, Florian Bayer, Stineke van Houte, Ben Longdon, Will Gaze, Angus Buckling
Short-term evolution under copper stress increases probability of plasmid uptake
published pages: 610873, ISSN: , DOI:
bioRxiv 2020-02-05
2019 Matthias C. Rillig, Anderson Abel de Souza Machado, Anika Lehmann, Uli Klümper
Evolutionary implications of microplastics for soil biota
published pages: 3, ISSN: 1448-2517, DOI: 10.1071/en18118
Environmental Chemistry 16/1 2020-02-05
2019 Zongbao Liu, Uli Klümper, Yang Liu, Yuchun Yang, Qiaoyan Wei, Jih-Gaw Lin, Ji-Dong Gu, Meng Li
Metagenomic and metatranscriptomic analyses reveal activity and hosts of antibiotic resistance genes in activated sludge
published pages: 208-220, ISSN: 0160-4120, DOI: 10.1016/j.envint.2019.05.036
Environment International 129 2020-02-05
2018 Kornelia Smalla, Kimberly Cook, Steven P Djordjevic, Uli Klümper, Michael Gillings
Environmental dimensions of antibiotic resistance: assessment of basic science gaps
published pages: , ISSN: 1574-6941, DOI: 10.1093/femsec/fiy195
FEMS Microbiology Ecology 94/12 2020-02-05
2019 Zongbao Liu, Uli Klümper, Lei Shi, Lei Ye, Meng Li
From Pig Breeding Environment to Subsequently Produced Pork: Comparative Analysis of Antibiotic Resistance Genes and Bacterial Community Composition
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.00043
Frontiers in Microbiology 10 2020-02-05

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The information about "SARCOM" are provided by the European Opendata Portal: CORDIS opendata.

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