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ZINCLAPS

Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degeneration.

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ZINCLAPS project word cloud

Explore the words cloud of the ZINCLAPS project. It provides you a very rough idea of what is the project "ZINCLAPS" about.

laps    life    cell    conjunction    planar    fluxes    technique    surfaces    functional    slow    quality    altered    potentiometric    agerelated    concentrations    pharmaceutical    attractive    spatiotemporal    fluorescence    initiation    elucidate    despite    cells    disorders    beneficial    potentials    eye    attachment    tool    photon    zinc    resolution    supplementation    molecular    conventional    reverse    play    cellular    cancer    time    light    electrophysiological    amd    retinal    industry    combined    forestall    alzheimer    treatments    contain    macular    disease    setup    addressable    accessible    surface    population    ion    basal    area    extracellular    electrochemical    poor    submicron    analysing    prevent    diabetes    scanning    degeneration    suffer    balance    health    either    physiological    suspected    treatment    ageing    imaging    retina    epithelium    underlying    participates    concentration    speed    microscopy    sensors    channel    deposits    pancreatic    diseases    sensitive    age    polarisation    pigment    events   

Project "ZINCLAPS" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
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surname: n.a.
function: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.sems.qmul.ac.uk/staff/research/s.krause
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-21   to  2019-08-24

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Light-addressable potentiometric sensors (LAPS) have great potential as a tool for functional electrochemical imaging of the attachment area of cells, providing information such as ion concentration, extracellular potentials and ion channel activity. The technique is particularly attractive for analysing cell responses of cells with planar polarisation as the cell-surface attachment area is not accessible to conventional electrophysiological measurements. However, current systems suffer either from poor resolution or slow scanning speed. In this project, we propose to develop a novel LAPS setup with high spatiotemporal resolution combined with two-photon fluorescence microscopy that allows imaging of physiological processes with submicron resolution and in real time. Novel zinc sensitive surfaces will be developed and used in conjunction with the new high-resolution and high-speed LAPS setup to investigate the role of zinc in age related macular degeneration (AMD). The retina and the underlying retinal pigment epithelium contain high concentrations of zinc. Several eye disorders are associated with altered zinc balance, and zinc supplementation has become a choice of treatment for diseases like agerelated macular degeneration. Despite its importance in health and diseases of the eye, it is still not well understood how zinc participates in cellular and molecular events and how zinc supplementation might be beneficial. We will investigate zinc fluxes at the basal side of the retinal pigment epithelium where zinc is suspected to play a key role in the formation of deposits and the initiation of AMD. The results of the study may lead to new treatments to prevent, forestall, or reverse the effects of the disease and may also help to elucidate zinc's role in other diseases including type 2 diabetes, pancreatic cancer, and Alzheimer disease and are therefore expected to impact the pharmaceutical industry and increase the quality of life for an ageing population.

 Publications

year authors and title journal last update
List of publications.
2019 Fan Wu, Bo Zhou, Jian Wang, Muchun Zhong, Anirban Das, Michael Watkinson, Karin Hing, De-Wen Zhang, Steffi Krause
Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges
published pages: 5896-5903, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b00304
Analytical Chemistry 91/9 2020-01-27
2019 Bo Zhou, Anirban Das, Menno J. Kappers, Rachel A. Oliver, Colin J. Humphreys, Steffi Krause
InGaN as a Substrate for AC Photoelectrochemical Imaging
published pages: 4386, ISSN: 1424-8220, DOI: 10.3390/s19204386
Sensors 19/20 2020-01-27

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