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ZINCLAPS

Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degeneration.

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 ZINCLAPS project word cloud

Explore the words cloud of the ZINCLAPS project. It provides you a very rough idea of what is the project "ZINCLAPS" about.

basal    agerelated    speed    participates    combined    fluxes    play    degeneration    spatiotemporal    sensitive    population    setup    scanning    tool    sensors    electrophysiological    eye    disorders    balance    concentrations    prevent    pigment    technique    suffer    channel    attractive    diseases    imaging    epithelium    retina    submicron    quality    supplementation    retinal    reverse    cell    resolution    surface    addressable    suspected    concentration    elucidate    forestall    deposits    altered    cells    age    conjunction    health    area    macular    poor    functional    pharmaceutical    laps    treatments    attachment    amd    light    either    electrochemical    events    despite    surfaces    molecular    alzheimer    slow    extracellular    fluorescence    disease    life    polarisation    potentiometric    industry    ion    pancreatic    diabetes    planar    physiological    underlying    potentials    conventional    cellular    initiation    zinc    ageing    beneficial    photon    contain    microscopy    accessible    analysing    cancer    treatment    time   

Project "ZINCLAPS" data sheet

The following table provides information about the project.

Coordinator		 QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
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surname: n.a.
function: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.sems.qmul.ac.uk/staff/research/s.krause
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-21   to  2019-08-24

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Light-addressable potentiometric sensors (LAPS) have great potential as a tool for functional electrochemical imaging of the attachment area of cells, providing information such as ion concentration, extracellular potentials and ion channel activity. The technique is particularly attractive for analysing cell responses of cells with planar polarisation as the cell-surface attachment area is not accessible to conventional electrophysiological measurements. However, current systems suffer either from poor resolution or slow scanning speed. In this project, we propose to develop a novel LAPS setup with high spatiotemporal resolution combined with two-photon fluorescence microscopy that allows imaging of physiological processes with submicron resolution and in real time. Novel zinc sensitive surfaces will be developed and used in conjunction with the new high-resolution and high-speed LAPS setup to investigate the role of zinc in age related macular degeneration (AMD). The retina and the underlying retinal pigment epithelium contain high concentrations of zinc. Several eye disorders are associated with altered zinc balance, and zinc supplementation has become a choice of treatment for diseases like agerelated macular degeneration. Despite its importance in health and diseases of the eye, it is still not well understood how zinc participates in cellular and molecular events and how zinc supplementation might be beneficial. We will investigate zinc fluxes at the basal side of the retinal pigment epithelium where zinc is suspected to play a key role in the formation of deposits and the initiation of AMD. The results of the study may lead to new treatments to prevent, forestall, or reverse the effects of the disease and may also help to elucidate zinc's role in other diseases including type 2 diabetes, pancreatic cancer, and Alzheimer disease and are therefore expected to impact the pharmaceutical industry and increase the quality of life for an ageing population.

 Publications

year authors and title journal last update
List of publications.
2019 Fan Wu, Bo Zhou, Jian Wang, Muchun Zhong, Anirban Das, Michael Watkinson, Karin Hing, De-Wen Zhang, Steffi Krause
Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges
published pages: 5896-5903, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b00304 		Analytical Chemistry 91/9 2020-01-27
2019 Bo Zhou, Anirban Das, Menno J. Kappers, Rachel A. Oliver, Colin J. Humphreys, Steffi Krause
InGaN as a Substrate for AC Photoelectrochemical Imaging
published pages: 4386, ISSN: 1424-8220, DOI: 10.3390/s19204386 		Sensors 19/20 2020-01-27

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