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MIRA

Characterizing Microbe-specific Immune Responses in the pathogenesis of Autoimmunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIRA project word cloud

Explore the words cloud of the MIRA project. It provides you a very rough idea of what is the project "MIRA" about.

heterogeneity    severity    immunological    fail    populations    mechanisms    vivo    foremost    inflammatory    dysregulation    microbial    treatment    techniques    intestinal    underlying    transgenic    sequencing    diversity    luminal    mucosal    regionalization    function    recognize    anatomically    cell    forms    cells    events    diseases    characterization    ibd    homing    cutting    alter    dramatically    immune    immunodominant    immunotherapies    cd4    functions    form    medical    therapeutic    disease    edge    antigen    regions    pathogenesis    balance    context    patients    proportion    shape    generation    microbiota    incidence    determines    exposed    little    deeply    differential    localization    therapy    mice    differentiation    cbir1    intestines    pivotal    single    antigens    anatomical    adaptive    chronic    localized    gut    severely    points    worldwide    population    tcr    comprise    commensal    rna    susceptibility    unmet    dysregulated    combine    helper    bowel    inflammation    plasticity   

Project "MIRA" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://villablancalab.com/
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 173˙857.00

Map

 Project objective

Dysregulation in the balance of CD4 T helper cell populations can severely alter susceptibility to a number of chronic inflammatory diseases, including inflammatory bowel disease (IBD). The incidence of IBD is dramatically increasing in Europe and worldwide and its therapy represents an important unmet medical need, since a significant proportion of patients fail to respond to currently available immunotherapies. Therefore, a better characterization of the immunological events underlying each form of IBD is of foremost importance. Increasing evidence points to the pivotal role of a dysregulated mucosal immune response to the intestinal microbiota in the pathogenesis of IBD. However, little is known about the mechanisms contributing to the generation of commensal-specific adaptive immune responses, and whether their differential localization can shape severity and anatomical extent of the disease. Indeed, the intestines comprise anatomically distinct regions that are exposed to different luminal antigens and this diversity eventually determines a regionalization of intestinal immune functions and microbiota-specific T cell responses. The aim of this proposal is to deeply characterize microbiota-specific T cell responses generated under different inflammatory conditions, in terms of differentiation, plasticity, heterogeneity, function and homing potential. To this aim, the proposed work will combine the use of CBir1 TCR transgenic mice, whose T cells recognize a microbial antigen that is immunodominant in IBD patients, and cutting-edge techniques such as single-cell RNA sequencing. By modelling the microbiota-specific immune response in vivo in the context of gut inflammation, I will characterize the function and homing properties of microbiota-specific T cells at the population and single-cell level, aiming at identifying new therapeutic targets for the treatment of localized forms of gut inflammation.

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The information about "MIRA" are provided by the European Opendata Portal: CORDIS opendata.

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