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MIRA

Characterizing Microbe-specific Immune Responses in the pathogenesis of Autoimmunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIRA project word cloud

Explore the words cloud of the MIRA project. It provides you a very rough idea of what is the project "MIRA" about.

disease    exposed    populations    chronic    little    regions    helper    intestinal    population    pathogenesis    gut    diseases    worldwide    vivo    commensal    fail    microbial    unmet    foremost    proportion    cell    immunological    deeply    dramatically    immune    determines    mechanisms    inflammation    tcr    transgenic    inflammatory    generation    dysregulated    susceptibility    immunotherapies    adaptive    shape    therapeutic    pivotal    bowel    cutting    plasticity    cd4    differentiation    immunodominant    anatomically    patients    medical    context    balance    points    localized    rna    intestines    comprise    dysregulation    recognize    microbiota    edge    forms    function    events    homing    cells    regionalization    localization    antigen    underlying    mucosal    characterization    techniques    cbir1    differential    incidence    treatment    luminal    heterogeneity    ibd    alter    antigens    single    functions    therapy    severity    diversity    severely    mice    combine    sequencing    anatomical    form   

Project "MIRA" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://villablancalab.com/
 Total cost 173˙857 €
 EC max contribution 173˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 173˙857.00

Map

 Project objective

Dysregulation in the balance of CD4 T helper cell populations can severely alter susceptibility to a number of chronic inflammatory diseases, including inflammatory bowel disease (IBD). The incidence of IBD is dramatically increasing in Europe and worldwide and its therapy represents an important unmet medical need, since a significant proportion of patients fail to respond to currently available immunotherapies. Therefore, a better characterization of the immunological events underlying each form of IBD is of foremost importance. Increasing evidence points to the pivotal role of a dysregulated mucosal immune response to the intestinal microbiota in the pathogenesis of IBD. However, little is known about the mechanisms contributing to the generation of commensal-specific adaptive immune responses, and whether their differential localization can shape severity and anatomical extent of the disease. Indeed, the intestines comprise anatomically distinct regions that are exposed to different luminal antigens and this diversity eventually determines a regionalization of intestinal immune functions and microbiota-specific T cell responses. The aim of this proposal is to deeply characterize microbiota-specific T cell responses generated under different inflammatory conditions, in terms of differentiation, plasticity, heterogeneity, function and homing potential. To this aim, the proposed work will combine the use of CBir1 TCR transgenic mice, whose T cells recognize a microbial antigen that is immunodominant in IBD patients, and cutting-edge techniques such as single-cell RNA sequencing. By modelling the microbiota-specific immune response in vivo in the context of gut inflammation, I will characterize the function and homing properties of microbiota-specific T cells at the population and single-cell level, aiming at identifying new therapeutic targets for the treatment of localized forms of gut inflammation.

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The information about "MIRA" are provided by the European Opendata Portal: CORDIS opendata.

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