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CO-DEfENDENCE SIGNED
Bacteriophages, phage-host interactions and evolution of defence mechanisms in beneficial bacterium Propionibacterium freudenreichii
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0CO-DEfENDENCE project word cloud
Explore the words cloud of the CO-DEfENDENCE project. It provides you a very rough idea of what is the project "CO-DEfENDENCE" about.
innovative
bacteriophages
phages
diverse
defendence
multitude
food
added
hosts
benefit
genomic
itself
samples
bacterial
led
class
benefits
phenomena
specialists
freudenreichii
employed
guidance
protecting
phenotypic
multidisciplinary
copenhagen
closely
translated
proteomic
defence
health
documented
uses
world
b12
therapies
genera
understudied
genetic
active
subjected
origin
elucidation
infecting
actinobacterium
co
imaging
race
actinobacteria
diversity
mechanisms
vitamin
material
time
causing
combination
perspective
tools
strains
suggest
severely
aid
pathogenic
arms
universities
interactions
isolated
bacterium
university
human
grade
protect
propionibacterium
attacking
attacks
phage
systematic
Project "CO-DEfENDENCE" data sheet
The following table provides information about the project.
| Coordinator |
KOBENHAVNS UNIVERSITET
Organization address contact info |
| Coordinator Country | Denmark [DK] |
| Total cost | 219˙312 € |
| EC max contribution | 219˙312 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2018 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-01-01 to 2021-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KOBENHAVNS UNIVERSITET | DK (KOBENHAVN) | coordinator | 219˙312.00 |
Map
Project objective
Bacteriophages (phages) infecting Propionibacterium freudenreichii, a bacterium known for production of active vitamin B12 and for causing well-documented benefits to human health, are more diverse than those identified for closely related genera. At the same time, the defence mechanisms protecting the bacterial strains (hosts) from phage attacks are more diverse as well. These two phenomena suggest that P. freudenreichii strains and their phages have experienced complex interactions in phage-bacterium arms race. However, both phages attacking, and the defence mechanisms that this important food-grade Actinobacterium uses to protect itself from phage attacks are currently severely understudied. In CO-DEfENDENCE, I will use an innovative approach of systematic study of the defence mechanisms not only from the perspective of the bacterium, but also from the perspective of the phage. The use of strains and phages isolated from samples of different origin will ensure diversity of material subjected to analyses by a combination of phenotypic, genomic, proteomic and imaging methods. This multidisciplinary approach is possible due to guidance offered by world-class phage specialists at one of the world’s top universities, the University of Copenhagen. The expected result of CO-DEfENDENCE is elucidation of complex interactions between P. freudenreichii and its phages, which led to the high diversity of the phages and the multitude of defence mechanisms employed by the strains. As an added benefit, these results have a great potential for being translated into novel genetic tools and to aid the development of phage therapies, especially those aimed at pathogenic Actinobacteria.
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The information about "CO-DEFENDENCE" are provided by the European Opendata Portal: CORDIS opendata.
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