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Repro_organoid SIGNED

Direct reprogramming of human astrocytes into functional neurons in cerebral organoids derived from genome edited hiPSCs

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Repro_organoid" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ 

Organization address
address: Langenbeckstrasse 1
city: Mainz
postcode: 55131
website: http://www.um-mainz.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2020-03-18

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ DE (Mainz) coordinator 171˙460.00

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 Project objective

Work over the last decade has shown that the genetic programs underlying cell identity are still plastic in terminally differentiated cells. Direct lineage reprogramming takes advantage of this plasticity to induce cell fate conversions from one cell type into another. This is achieved by forced expression of specific fate determinants, usually transcription factors that regulate cell fate during development. This proposal will allow me to address the fundamental biological question whether human glia can be reprogrammed within a human tissue setting, and if so, whether this depends on their state of maturation. I propose to study the possibility of converting human glia into induced neurons within an in vivo-like tissue context. Towards this I will employ cutting-edge techniques such as generation of cerebral organoids from human induced pluripotent stem cells (hiPSCs) and genome-editing techniques to allow for inducible expression of reprogramming factors in human glia at different maturation stages within the cerebral organoids. In order to perform the hiPSCs genome-editing I will use CRISPR/Cas9 technology which will permit me to obtain stable, cell-type specific and inducible hiPSC lines. This novel and valuable genome editing strategy will facilitate the use of different reprogramming factors sets in order to optimize the reprogramming of glial cells into functional neurons. This study may pave the way for translating direct lineage reprogramming into new strategies for brain repair.

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The information about "REPRO_ORGANOID" are provided by the European Opendata Portal: CORDIS opendata.

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