Opendata, web and dolomites

IMMUNO_CRC SIGNED

Microbiota-immune interaction in colorectal cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IMMUNO_CRC project word cloud

Explore the words cloud of the IMMUNO_CRC project. It provides you a very rough idea of what is the project "IMMUNO_CRC" about.

microbiota    differentially    phenotype    laboratory    influence    tract    creates    cancer    function    decade    roles    innovative    therapeutic    colorectal    types    immune    neurological    environment    inflammation    immuno    treatment    pave    benefits    manipulating    data    outcomes    therapy    members    mechanisms    carcinogenesis    human    patients    therapeutics    health    co    combination    metabolic    sub    hypothesize    mice    either    recruit    host    crc    harbours    outcome    bacteria    regulation    elucidate    play    certain    flow    strategies    free    profiles    interact    expression    cells    immunological    infiltrating    conferring    gut    last    alter    multicolour    composition    tumour    germ    histo    metabolites    cytometry    harbour    inflammatory    clinical    altered    gene    bacterial    ultimately    prognostic    biopsies    disease    mucosal    immunophenotyping    oncogenesis    techniques    trillions    progression    appear    metabolomics    investigation    microbial    gastrointestinal    assemblage   

Project "IMMUNO_CRC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 187˙866.00

Map

 Project objective

The human gastrointestinal tract harbours trillions of bacteria that have co-evolved to play important roles in health and disease, conferring immunological, metabolic and neurological benefits to the host. This assemblage is known as the Gut Microbiota and has been a focus of investigation over the last decade. Altered gut microbiota composition has been associated with colorectal cancer (CRC), and studies in germ-free mice established an important role for some gut microbiota members in oncogenesis outcome, tumour progression and response to therapy. Data from the host laboratory show that patients with CRC harbour specific gut microbiota sub-types, among which some are associated with distinct mucosal gene-expression profiles. Thus either directly or through their metabolites, these tumour-associated microbiota appear to differentially recruit and interact with host inflammatory cells, which we hypothesize may be involved in different outcomes of carcinogenesis. The presence of particular immune cells is known to be prognostic of clinical outcome, because it often creates a tumour-promoting environment. Therefore, strategies aimed at manipulating the tumour-associated microbiota in CRC represent a promising therapeutic approach for patients. IMMUNO-CRC’s goal is to elucidate the mechanisms by which certain bacterial sub-types associated with CRC may alter immune function and influence clinical outcome. Using multicolour flow cytometry, I will analyse infiltrating immune cells characteristic of different inflammatory responses and microbiota sub-types. Histo-immunophenotyping analysis on tumour biopsies will determine their inflammation and cancer phenotype. Metabolomics will identify specific microbial metabolites involved in the regulation and progression of inflammation. Ultimately, this unique and innovative combination of techniques will pave the way for novel therapeutics targeting the human microbiota for cancer treatment.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNO_CRC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNO_CRC" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

ToMComputations (2019)

How other minds are represented in the human brain: Neural computations underlying Theory of Mind

Read More  

DEMOS (2019)

Disfluencies and Eye MOvements during Speech: what can they reveal about language production?

Read More