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IMMUNO_CRC SIGNED

Microbiota-immune interaction in colorectal cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IMMUNO_CRC project word cloud

Explore the words cloud of the IMMUNO_CRC project. It provides you a very rough idea of what is the project "IMMUNO_CRC" about.

progression    regulation    alter    infiltrating    outcomes    host    histo    mice    laboratory    techniques    mechanisms    conferring    gastrointestinal    flow    function    cancer    inflammatory    composition    manipulating    expression    human    strategies    sub    profiles    appear    neurological    roles    ultimately    elucidate    either    health    hypothesize    treatment    influence    clinical    combination    colorectal    multicolour    mucosal    assemblage    therapeutic    disease    immune    benefits    metabolites    harbour    biopsies    carcinogenesis    therapeutics    phenotype    innovative    inflammation    tract    types    altered    co    data    differentially    gut    cytometry    certain    microbial    metabolomics    metabolic    play    immunophenotyping    free    immuno    harbours    interact    environment    members    outcome    creates    immunological    therapy    gene    recruit    patients    investigation    germ    pave    oncogenesis    tumour    decade    bacterial    trillions    crc    prognostic    bacteria    last    microbiota    cells   

Project "IMMUNO_CRC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK 

Organization address
address: WESTERN ROAD
city: Cork
postcode: T12 YN60
website: www.ucc.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) coordinator 187˙866.00

Map

 Project objective

The human gastrointestinal tract harbours trillions of bacteria that have co-evolved to play important roles in health and disease, conferring immunological, metabolic and neurological benefits to the host. This assemblage is known as the Gut Microbiota and has been a focus of investigation over the last decade. Altered gut microbiota composition has been associated with colorectal cancer (CRC), and studies in germ-free mice established an important role for some gut microbiota members in oncogenesis outcome, tumour progression and response to therapy. Data from the host laboratory show that patients with CRC harbour specific gut microbiota sub-types, among which some are associated with distinct mucosal gene-expression profiles. Thus either directly or through their metabolites, these tumour-associated microbiota appear to differentially recruit and interact with host inflammatory cells, which we hypothesize may be involved in different outcomes of carcinogenesis. The presence of particular immune cells is known to be prognostic of clinical outcome, because it often creates a tumour-promoting environment. Therefore, strategies aimed at manipulating the tumour-associated microbiota in CRC represent a promising therapeutic approach for patients. IMMUNO-CRC’s goal is to elucidate the mechanisms by which certain bacterial sub-types associated with CRC may alter immune function and influence clinical outcome. Using multicolour flow cytometry, I will analyse infiltrating immune cells characteristic of different inflammatory responses and microbiota sub-types. Histo-immunophenotyping analysis on tumour biopsies will determine their inflammation and cancer phenotype. Metabolomics will identify specific microbial metabolites involved in the regulation and progression of inflammation. Ultimately, this unique and innovative combination of techniques will pave the way for novel therapeutics targeting the human microbiota for cancer treatment.

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The information about "IMMUNO_CRC" are provided by the European Opendata Portal: CORDIS opendata.

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