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MAPGenome

Mapping migration and adaptation in genomes

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EC-Contrib. €

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Project "MAPGenome" data sheet

The following table provides information about the project.

Coordinator
FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS 

Organization address
address: CAMPO GRANDE, EDIFICIO C1, PISO 3
city: LISBON
postcode: 1749 016
website: http://www.fciencias-id.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website https://ce3c.ciencias.ulisboa.pt/member/vitorsousa
 Total cost 148˙635 €
 EC max contribution 148˙635 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS PT (LISBON) coordinator 148˙635.00

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 Project objective

There is increasing evidence that gene flow between populations adapted to different environments is widespread in nature. Understanding this interplay of adaptation and migration at the genomic level is a fundamental goal of evolutionary biology, with wide applications in situations where these two forces operate, e.g. pesticide resistance or species invasion. Yet, this goal remains largely elusive, mainly because genetic signatures of local adaptation are confounded by other evolutionary processes, such as past demography, the removal of deleterious mutations and recombination. I will address this by integrating new computational methods with new data from experimental evolution and field populations. First, I will develop a method to map gene flow along the genome to find regions under divergent selection, taking the challenging step of modelling recombination and background selection. I will then apply it to characterize the spread of pesticide resistance in field populations of a major crop pest, Tetranychus urticae (spider mite). Due to their small genome (90Mb) and haplodidploidy, we have the unique opportunity to get phased genomes from haploid males. Third, by training-through-research, I will follow mites (and their genomes) evolving under controlled selection regimes in the laboratory (with vs without pesticide), varying migration rates. Combining my background on population genomics with the PI’s knowledge in spider-mite evolutionary ecology and the excellent conditions for experimental evolution at the host institute, we will move the field towards a comprehensive characterization of the genomics of adaptation in face of gene flow. The new method will be of general application to address fundamental questions on speciation and ecology, while providing a transferable framework to tackle societal challenges, from agriculture to human health and global change (e.g. find genes responsible for human disease and crop response to increasing temperatures).

 Publications

year authors and title journal last update
List of publications.
2019 Martin Kuhlwilm, Sojung Han, Vitor C. Sousa, Laurent Excoffier, Tomas Marques-Bonet
Ancient admixture from an extinct ape lineage into bonobos
published pages: 957-965, ISSN: 2397-334X, DOI: 10.1038/s41559-019-0881-7
Nature Ecology & Evolution 3/6 2020-03-25
2019 David A. Marques, Kay Lucek, Vitor C. Sousa, Laurent Excoffier, Ole Seehausen
Admixture between old lineages facilitated contemporary ecological speciation in Lake Constance stickleback
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12182-w
Nature Communications 10/1 2020-03-25
2019 Vitor C Sousa, Flore Zélé, Leonor R Rodrigues, Diogo P Godinho, Maud Charlery de la Masselière, Sara Magalhães
Rapid host-plant adaptation in the herbivorous spider mite Tetranychus urticae occurs at low cost
published pages: 82-89, ISSN: 2214-5745, DOI: 10.1016/j.cois.2019.08.006
Current Opinion in Insect Science 36 2020-03-25
2019 Sofia L Mendes; Manuela M Coelho; Vitor C Sousa
Population genomics data supports introgression between Western Iberian Squalius freshwater fish species from different drainages
published pages: , ISSN: , DOI: 10.1101/585687
bioRxiv 2020-03-25

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