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FGFSTAB

Industrial Production of Stable Fibroblast Growth Factors for Regenerative Medicine and Related Research Areas

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 FGFSTAB project word cloud

Explore the words cloud of the FGFSTAB project. It provides you a very rough idea of what is the project "FGFSTAB" about.

chronic    tissue    fireprot    greatest    financial    investing    demanding    world    frequent    authorization    fact    market    engineering    biotechnological    manufacturing    dressings    commercial    skin    course    embryonic    stability    additional    goes    heavily    diabetes    clinical    care    slow    platform    stable    limited    instrument    thermal    angiogenesis    marketing    healing    risk    life    technological    started    population    effectiveness    homeostasis    practise    trials    play    global    ulcers    administrations    proprietary    stress    incidences    protein    see    sme    ageing    obesity    primarily    wound    therapy    aging    safe    innovative    close    hours    natural    gap    fgf    medicine    good    body    trauma    fgfstab    despite    surgical    treatment    organisms    rising    regenerative    minutes    companies    poor    expertise    closes    proteins    enantis    optimization    adverse    fibroblast    cleared    industrial    circulation    necessitating    lower    fgfs    half   

Project "FGFSTAB" data sheet

The following table provides information about the project.

Coordinator
ENANTIS SRO 

Organization address
address: KAMENICE 771/34
city: BRNO
postcode: 625 00
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Czech Republic [CZ]
 Project website https://www.enantis.com/fgfstab/
 Total cost 1˙030˙000 €
 EC max contribution 1˙030˙000 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2016-2017
 Funding Scheme SME-2
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ENANTIS SRO CZ (BRNO) coordinator 1˙030˙000.00

Map

 Project objective

The FGFSTAB project closes the gap between Enantis knowledge and expertise on protein engineering and the commercial applications of stable fibroblast growth factors (FGFs). FGFs are essential to the embryonic development, maintain tissue homeostasis, may slow down ageing of the organisms, and primarily promote angiogenesis and wound healing. FGFs see the greatest application in the care and treatment of chronic skin ulcers, but find use also in surgical and trauma wound healing. The global wound care market is rapidly growing due to the rising aging population and growing incidences of obesity and diabetes. Advanced wound dressings, such as those involving growth factors, play an important role in current regenerative medicine and companies around the world have started investing heavily in research and development of growth factor-based products. However, despite clinical value, applications of FGFs are limited by the fact that natural proteins have poor thermal stability and a short half-life in the circulation; they are often cleared from the body within hours, if not minutes, thus necessitating frequent administrations during the course of treatment, which goes hand in hand with a higher risk of adverse effects and lower cost-effectiveness of the protein therapy. The key objective of the FGFSTAB project is to use an innovative technological platform, based on the application of Enantis proprietary protein optimization concept FireProt, to increase FGF stability under various stress conditions. Additional challenges including high cost of production, current Good Manufacturing Practise, development of delivery systems for safe and effective wound healing, and pre-clinical testing to support future clinical trials and marketing authorization, will be targeted as well. Financial support provided within SME Instrument phase 2 will help us to close the gap from demanding biotechnological development to the target industrial application in regenerative medicine.

 Deliverables

List of deliverables.
FGFSTAB web presentation Websites, patent fillings, videos etc. 2019-09-09 15:23:38

Take a look to the deliverables list in detail:  detailed list of FGFSTAB deliverables.

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The information about "FGFSTAB" are provided by the European Opendata Portal: CORDIS opendata.

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