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MIREDI

Mechanisms of Immune Receptor Diversification in Cereals

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MIREDI project word cloud

Explore the words cloud of the MIREDI project. It provides you a very rough idea of what is the project "MIREDI" about.

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Project "MIREDI" data sheet

The following table provides information about the project.

Coordinator
EARLHAM INSTITUTE 

Organization address
address: NORWICH RESEARCH PARK COLNEY LANE
city: NORWICH
postcode: NR4 7UZ
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.krasilevalab.org
 Total cost 1˙499˙997 €
 EC max contribution 1˙499˙997 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EARLHAM INSTITUTE UK (NORWICH) coordinator 882˙899.00
2    THE SAINSBURY LABORATORY UK (NORWICH) participant 617˙098.00

Map

 Project objective

The plant immune system is innate – it is encoded in the germline. In natural pathosystems, plants efficiently deploy hundreds of immune receptors to detect and disarm rapidly evolving pathogens including viruses, bacteria, nematodes, insects, fungi and oomycetes. Exactly how such receptor diversity can evolve is an elusive question with important practical ramifications. A central class of plant immune receptors, called Nucleotide Binding Leucine Rich Repeats proteins (NLR), has been implicated in recognition of vastly diverse pathogen-derived effector molecules. An emerging paradigm of receptor diversification in plant genomes involves new gene fusions of receptors with host proteins that are normally targeted by pathogen effectors. Such fusion receptors ‘bait’ pathogens and their integrated domains are thought to function as ‘decoys’ or ‘sensors’ that mediate pathogen recognition. I have recently demonstrated that the mechanism of generating new receptors through gene fusions originated at least 500 million years ago in mosses and is common to all flowering plants. Here, I propose to decode the mechanisms of plant immune receptor diversification by gene fusions by studying diversity and functions of immune receptors in grasses, a young highly diversified plant family that includes the three most important crops: maize, rice and wheat. My specific aims are to:

1) Determine rates of receptor diversification within and across genomes 2) Dissect the mechanisms of receptor regulation and receptor activation 3) Generate novel plant immune receptors based on the NLR platform prone to fusions.

In this MIREDI research programme, I will combine state of the art sequencing techniques and bioinformatics, molecular biology and novel reverse genetics techniques to study how plant immune system co-evolves with pathogens and what limits diversification of immunity in domesticated crops.

 Publications

year authors and title journal last update
List of publications.
2018 Schudoma, Christian; Jackson, William; Baggs, Erin; Moscou, Matthew; Krasileva, Ksenia; Dagdas, Gulay; Haerty, Wilfried; Bailey, Paul
Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions
published pages: 19-23, ISSN: 1664-462X, DOI: 10.1101/100834
Genome Biology 1 2019-07-19

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