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PROGLUTASIS SIGNED

Protection of cardiometabolic inflammation by modulation of myeloid glutamine homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 PROGLUTASIS project word cloud

Explore the words cloud of the PROGLUTASIS project. It provides you a very rough idea of what is the project "PROGLUTASIS" about.

combination    nutrients    immunometabolic    disease    emerged    usa    public    risk    abundant    intervene    regulation    hematopoiesis    energy    diabetes    30    validate    origin    stress    ubiquitous    ratio    population    traits    acid    mets    glutamine    glutaminolysis    source    proliferative    association    linking    glutamate    cardiometabolic    hematopoietic    atherosclerosis    progression    apportioning    diseases    flexibility    medical    chronic    dampening    trajectory    alteration    homeostasis    notion    community    therapeutic    mechanism    proglutasis    occurring    poorly    mechanisms    grade    onset    direct    inflammation    functional    molecular    health    ultimately    elusive    obesity    macrophage    syndrome    follows    risks    prevalence    worldwide    metabolic    perspective    disorders    underlying    immune    amino    immunosuppressive    reflects    favor    dynamics    cardiovascular    cells    appreciation    contribution    considerable    inflammatory    plasma    function    despite    strategies   

Project "PROGLUTASIS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙091˙338 €
 EC max contribution 2˙091˙338 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙091˙338.00

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 Project objective

The metabolic syndrome (MetS) represents one of the major public health challenges worldwide. It reflects a combination of medical disorders that, when occurring together, increase the risk of developing diabetes and cardiovascular disease. The prevalence in the USA is estimated at 30% of the population and the European community follows this trajectory. It is now recognized that the state of chronic low-grade inflammation may favor the onset and progression of the MetS. While the notion of metabolic flexibility in hematopoietic cells has recently emerged in several inflammatory diseases, the origin of this immunometabolic alteration in the MetS remains elusive. There is a growing appreciation that the apportioning of nutrients into different metabolic pathways can support or direct functional immune and hematopoietic changes. Glutamine is the most abundant amino acid in the plasma and an important energy source through glutaminolysis. Despite its potential proliferative and/or immunosuppressive function and the strong association between high glutamine-to-glutamate ratio with cardiometabolic traits, the underlying mechanisms are poorly understood. Thus, there is a considerable therapeutic interest in better understanding the mechanisms linking glutamine to cardiometabolic risks and in particular cardiometabolic inflammation. In PROGLUTASIS, we will investigate the metabolic and immune regulation of glutamine homeostasis in the metabolic syndrome. We will validate the contribution of glutaminolysis in cardiometabolic inflammation, including obesity, diabetes and atherosclerosis through its role on hematopoiesis and macrophage dynamics. Given the ubiquitous association between glutamine and chronic metabolic stress, we expect that identifying the underlying molecular mechanism will offer novel therapeutic perspective on how to intervene in this pathway. This will ultimately allow for tailored strategies aimed at dampening cardiometabolic inflammation in the MetS.

 Publications

year authors and title journal last update
List of publications.
2019 Laurent Yvan-Charvet, Johanna Merlin
Le sommeil protège-t-il nos vaisseaux sanguins ?
published pages: 743-746, ISSN: 0767-0974, DOI: 10.1051/medsci/2019147
médecine/sciences 35/10 2019-11-25
2019 Laurent Yvan-Charvet, Fabrizia Bonacina, Rodolphe Renè Guinamard, Giuseppe Danilo Norata
Immunometabolic function of cholesterol in cardiovascular disease and beyond
published pages: 1393-1407, ISSN: 0008-6363, DOI: 10.1093/cvr/cvz127
Cardiovascular Research 115/9 2019-11-25
2019 Stoyan Ivanov, Alexandre Gallerand, Marilyn Gros, Marion I. Stunault, Johanna Merlin, Nathalie Vaillant, Laurent Yvan‐Charvet, Rodolphe R. Guinamard
Mesothelial cell CSF1 sustains peritoneal macrophage proliferation
published pages: 2012-2018, ISSN: 0014-2980, DOI: 10.1002/eji.201948164
European Journal of Immunology 49/11 2019-11-25
2019 Laurent Yvan-Charvet, Lai Guan Ng
Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act
published pages: 598-612, ISSN: 1471-4906, DOI: 10.1016/j.it.2019.05.004
Trends in Immunology 40/7 2019-11-25
2018 Laurent Yvan-Charvet, Bertrand Cariou
Poststatin era in atherosclerosis management
published pages: 1, ISSN: 0957-9672, DOI: 10.1097/MOL.0000000000000505
Current Opinion in Lipidology 2019-04-18
2018 Laurent Yvan-Charvet, Filip K Swirski
Is defective cholesterol efflux an integral inflammatory component in myelopoiesis-driven cardiovascular diseases?
published pages: 2168-2171, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy269
European Heart Journal 39/23 2019-04-18

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