Explore the words cloud of the PROGLUTASIS project. It provides you a very rough idea of what is the project "PROGLUTASIS" about.
The following table provides information about the project.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
|Coordinator Country||France [FR]|
|Total cost||2˙091˙338 €|
|EC max contribution||2˙091˙338 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-04-01 to 2022-03-31|
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|1||INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE||FR (PARIS)||coordinator||2˙091˙338.00|
The metabolic syndrome (MetS) represents one of the major public health challenges worldwide. It reflects a combination of medical disorders that, when occurring together, increase the risk of developing diabetes and cardiovascular disease. The prevalence in the USA is estimated at 30% of the population and the European community follows this trajectory. It is now recognized that the state of chronic low-grade inflammation may favor the onset and progression of the MetS. While the notion of metabolic flexibility in hematopoietic cells has recently emerged in several inflammatory diseases, the origin of this immunometabolic alteration in the MetS remains elusive. There is a growing appreciation that the apportioning of nutrients into different metabolic pathways can support or direct functional immune and hematopoietic changes. Glutamine is the most abundant amino acid in the plasma and an important energy source through glutaminolysis. Despite its potential proliferative and/or immunosuppressive function and the strong association between high glutamine-to-glutamate ratio with cardiometabolic traits, the underlying mechanisms are poorly understood. Thus, there is a considerable therapeutic interest in better understanding the mechanisms linking glutamine to cardiometabolic risks and in particular cardiometabolic inflammation. In PROGLUTASIS, we will investigate the metabolic and immune regulation of glutamine homeostasis in the metabolic syndrome. We will validate the contribution of glutaminolysis in cardiometabolic inflammation, including obesity, diabetes and atherosclerosis through its role on hematopoiesis and macrophage dynamics. Given the ubiquitous association between glutamine and chronic metabolic stress, we expect that identifying the underlying molecular mechanism will offer novel therapeutic perspective on how to intervene in this pathway. This will ultimately allow for tailored strategies aimed at dampening cardiometabolic inflammation in the MetS.
|year||authors and title||journal||last update|
Laurent Yvan-Charvet, Johanna Merlin
Le sommeil protÃ¨ge-t-il nos vaisseaux sanguins ?
published pages: 743-746, ISSN: 0767-0974, DOI: 10.1051/medsci/2019147
Laurent Yvan-Charvet, Fabrizia Bonacina, Rodolphe RenÃ¨ Guinamard, Giuseppe Danilo Norata
Immunometabolic function of cholesterol in cardiovascular disease and beyond
published pages: 1393-1407, ISSN: 0008-6363, DOI: 10.1093/cvr/cvz127
|Cardiovascular Research 115/9||2019-11-25|
Stoyan Ivanov, Alexandre Gallerand, Marilyn Gros, Marion I. Stunault, Johanna Merlin, Nathalie Vaillant, Laurent Yvanâ€Charvet, Rodolphe R. Guinamard
Mesothelial cell CSF1 sustains peritoneal macrophage proliferation
published pages: 2012-2018, ISSN: 0014-2980, DOI: 10.1002/eji.201948164
|European Journal of Immunology 49/11||2019-11-25|
Laurent Yvan-Charvet, Lai Guan Ng
Granulopoiesis and Neutrophil Homeostasis: A Metabolic, Daily Balancing Act
published pages: 598-612, ISSN: 1471-4906, DOI: 10.1016/j.it.2019.05.004
|Trends in Immunology 40/7||2019-11-25|
Laurent Yvan-Charvet, Bertrand Cariou
Poststatin era in atherosclerosis management
published pages: 1, ISSN: 0957-9672, DOI: 10.1097/MOL.0000000000000505
|Current Opinion in Lipidology||2019-04-18|
Laurent Yvan-Charvet, Filip K Swirski
Is defective cholesterol efflux an integral inflammatory component in myelopoiesis-driven cardiovascular diseases?
published pages: 2168-2171, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehy269
|European Heart Journal 39/23||2019-04-18|
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