Explore the words cloud of the TAML-ArM project. It provides you a very rough idea of what is the project "TAML-ArM" about.
The following table provides information about the project.
Coordinator |
UNIVERSITAT BASEL
Organization address contact info |
Coordinator Country | Switzerland [CH] |
Project website | https://www.chemie.unibas.ch/ |
Total cost | 175˙419 € |
EC max contribution | 175˙419 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2016 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2017 |
Duration (year-month-day) | from 2017-04-01 to 2019-03-31 |
Take a look of project's partnership.
# | ||||
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1 | UNIVERSITAT BASEL | CH (BASEL) | coordinator | 175˙419.00 |
The oxygenation of inert C-H bonds is a highly challenging reaction that has an enormous untapped potential for the European chemical industry. Indeed, it offers attractive means to upgrade cheap hydrocarbons into high value-added products. Nature relies on iron-based enzymes and oxygen to perform such transformations. In a biomimetic spirit, catalytic alkane hydroxylation is best achieved using iron-based catalysts and H2O2 as oxidant. Compared to natural enzymes, however, such systems display modest performance. In the TAML-ArM project, we aim to the development of a novel approach that consists of creating an artificial alkane monooxygenase by introducing a highly active iron complex within a protein scaffold. This strategy, pioneered in the Ward group, has ample precedent for less challenging reactions, and it potentially represents a significant step forward in bioinspired hydroxylation chemistry. To achieve this goal artificial metalloenzymes merge homogeneous- and enzymatic catalysis, two traditionally complementary strategies. We envision that this approach will: i) improve the catalytic activity by protecting the highly reactive Fe=O-moiety by shielding it from undesirable side-reactions and ii) provide novel selectivities, owing to second coordination sphere interactions between the protein and the substrate. Thanks to this innovative catalytic approach, we will develop a paradigm shifting technology for the selective hydroxylation of hydrocarbons: the reactions will be performed in water at room temperature using benign H2O2 as oxidant.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Alexandria Deliz Liang, Joan Serrano-Plana, Ryan L. Peterson, Thomas R. Ward Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology: Enzymatic Cascades and Directed Evolution published pages: 585-595, ISSN: 0001-4842, DOI: 10.1021/acs.accounts.8b00618 |
Accounts of Chemical Research 52/3 | 2019-06-06 |
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The information about "TAML-ARM" are provided by the European Opendata Portal: CORDIS opendata.
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