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ChiLTERN SIGNED

Children’s Liver Tumour European Research Network

Total Cost €

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EC-Contrib. €

0

Partnership

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 ChiLTERN project word cloud

Explore the words cloud of the ChiLTERN project. It provides you a very rough idea of what is the project "ChiLTERN" about.

patients    safely    surgery    transplant    therapy    population    tests    genetic    approximately    resection    damage    young    operation    cancer    receive    health    serious    toxicities    commonest    surgical    trial    hcc    assign    relates    see       correct    10    phc    ultimately    underlying    diseases    interventions    surgeons    linked    era    clinical    usually    chemotherapy    establishing    survival    operations    sometimes    hepatic    18    kidney    fewer    phitt    toxic    risk    adapt    plan    paediatric    hepatocellular    partnership    questions    biological    children    international    care    randomised    hb    biomarkers    incidence    undergo    infants    patient    accurately    chiltern    amount    move    global    cure    expose    opportunity    carcinoma    rarer    liver    hepatoblastoma    tools    rare    groups    detect    teenage    builds    subgroups    childhood    heart    cancers    six    monitor    personalised    tumour    safe    treatment    cirrhotic    single    prevent    deafness    imaging    million    effectiveness    undertaken   

Project "ChiLTERN" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.birmingham.ac.uk/generic/chiltern/index.aspx
 Total cost 8˙191˙665 €
 EC max contribution 7˙941˙665 € (97%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 3˙127˙320.00
2    INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL ES (BADALONA BARCELONA) participant 990˙456.00
3    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 702˙250.00
4    CENTRE HOSPITALIER UNIVERSITAIRE DE RENNES FR (RENNES CEDEX 9) participant 472˙356.00
5    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 406˙250.00
6    CINECA CONSORZIO INTERUNIVERSITARIO IT (CASALECCHIO DI RENO BO) participant 281˙250.00
7    CLINIQUES UNIVERSITAIRES SAINT-LUC BE (BRUXELLES) participant 236˙402.00
8    UNIVERSITATSKLINIKUM BONN DE (BONN) participant 230˙500.00
9    SERVICIO ANDALUZ DE SALUD ES (SEVILLA) participant 187˙575.00
10    GDANSKI UNIWERSYTET MEDYCZNY PL (GDANSK) participant 181˙425.00
11    AZIENDA OSPEDALIERA DI PADOVA IT (PADOVA) participant 177˙275.00
12    ISTITUTO DI RICERCA PEDIATRICA CITTA DELLA SPERANZA IT (PADOVA) participant 130˙000.00
13    CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL DE (KIEL) participant 121˙875.00
14    VASTRA GOTALANDS LANS LANDSTING SE (VANERSBORG) participant 117˙825.00
15    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) participant 107˙387.00
16    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 105˙625.00
17    OUR LADYS CHILDRENS HOSPITAL CRUMLIN IE (DUBLIN) participant 92˙262.00
18    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) participant 87˙655.00
19    MEVIS MEDICAL SOLUTIONS AG DE (BREMEN) participant 75˙000.00
20    PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV NL (UTRECHT) participant 48˙000.00
21    FAKULTNI NEMOCNICE V MOTOLE CZ (PRAHA 5) participant 36˙725.00
22    XENTECH SAS FR (Evry) participant 26˙250.00
23    SCHWEIZERISCHE PADIATRISCHE ONKOLOGIE GRUPPE (SPOG) CH (BERN) participant 0.00

Map

 Project objective

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying cirrhotic liver diseases. The ChiLTERN project relates to topic PHC 18 ‘establishing effectiveness of health care interventions in the paediatric population’. The ChiLTERN project builds on a unique opportunity to undertake a comprehensive research programme linked to an ambitious global partnership which will see the single largest clinical trial (the Paediatric Hepatic International Tumour Trial - PHITT) ever undertaken in this population of patients, with several randomised questions in six subgroups of patients. ChiLTERN will allow us to move towards an era of personalised therapy in which each patient will receive the correct amount of chemotherapy and will undergo has the best surgical operation (surgical resection or liver transplant). By using both clinical and biological information, we can assign patients more accurately to risk groups based on their survival. Using genetic tests and biomarkers, we will determine those children who may be at risk of developing long term side effects (deafness, heart failure, kidney damage). In addition, biomarkers will allow us to monitor during therapy and detect toxicities early before serious damage is done so that we can adapt treatment and prevent these problems. Finally, we will be using imaging technology tools which will help our surgeons plan liver operations more safely and effectively. Ultimately ChiLTERN will allow us to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe.

 Deliverables

List of deliverables.
Publication Policy Documents, reports 2020-04-07 20:37:05
Registration in ISRCTN Websites, patent fillings, videos etc. 2020-04-07 20:37:05
Protocols for standardised collection of clinical samples and sample analysis Documents, reports 2020-04-07 20:37:05
Project Data Management Plan Documents, reports 2020-04-07 20:37:05
Dissemination and Communication Plan: and updated regularly Documents, reports 2020-04-07 20:37:05
Protocol finalisation and submission to EC. Documents, reports 2020-04-07 20:37:05
Project Management Documents, reports 2020-04-07 20:37:04
Website activation Websites, patent fillings, videos etc. 2020-04-07 20:37:05

Take a look to the deliverables list in detail:  detailed list of ChiLTERN deliverables.

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The information about "CHILTERN" are provided by the European Opendata Portal: CORDIS opendata.

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