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ILTIS SIGNED

Innate-Like T-Cells In Sepsis (ILTIS): Implications for Early Diagnosis and Rescue of Immune Suppression.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ILTIS project word cloud

Explore the words cloud of the ILTIS project. It provides you a very rough idea of what is the project "ILTIS" about.

vitro    communities    outcomes    network    presentation    acute    bench    signatures    sepsis    aspiration    immune    pneumonia    scientist    earlier    viability    island    cellular    ill    phagocytosis    health    french    culture    renowned    virus    cell    pathogens    hsdf    create    resistant    career    investigations    tackle    innate    gamma    medical    phenotype    internationally    eacute    shock    la    types    am    research    neutrophils    antigen    cells    outbreaks    me    mediated    community    cytokine    pathogen    expertise    microbial    prevent    severe    treatment    host    skills    activation    acquired    chikungunya    reunion    multidrug    leptospirosis    clinical    death    diseases    translational    disease    deciphering    returning    bed    pose    union    monocytes    causative    molecular    bacteria    possibility    teams    link    myself    considerable    diagnosis    relation    spread    soluble    infectious    university    cytokines    infections    immunology    shaping    alarming    public    productive    scientific    delta    functions    septic    collaborations    function    analysing    benefit    join    worldwide    release    cardiff    pave    threats    fight    keen   

Project "ILTIS" data sheet

The following table provides information about the project.

Coordinator
CARDIFF UNIVERSITY 

Organization address
address: NEWPORT ROAD 30-36
city: CARDIFF
postcode: CF24 ODE
website: www.cardiff.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 97˙727 €
 EC max contribution 97˙727 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CARDIFF UNIVERSITY UK (CARDIFF) coordinator 97˙727.00

Map

 Project objective

Research on infectious diseases has high priority for the scientific and medical communities worldwide, to tackle the alarming spread of multidrug resistant bacteria and to fight and prevent virus outbreaks. On the French island of La Réunion, infections such as leptospirosis and chikungunya pose considerable threats for public health. My career aspiration is to establish myself as a clinical scientist in the field of immunology of microbial infections, especially in severe conditions such as septic shock and leptospirosis. I am also interested in deciphering the emerging role of host cell-derived factors (HSDF) in shaping the innate immune response. The immune response to pathogens and HSDF involves numerous cell types and soluble factors such as cytokines but remains ill-characterized. A better understanding of the cellular and molecular signatures in acute disease may pave the way to better and earlier diagnosis, targeted treatment and improved outcomes. The aim of the proposed study is to study the phenotype and function of innate immune cells during sepsis, with a particular focus on γδ T-cells, neutrophils and monocytes. This translational research involves bed to bench-side approaches (clinical investigations on septic shock during community-acquired pneumonia) and in vitro studies in cell culture, by analysing cell viability and activation as well as key cellular functions such as cytokine release, phagocytosis and antigen presentation in relation to the causative pathogen. I am keen to link this project with my previous studies on immune-mediated cell death during septic shock and on the early immune response to leptospirosis. The possibility to join the internationally renowned immunology teams at Cardiff University will be of great benefit to my research and will allow me to further my skills and expertise as well as create a network of productive collaborations for my future career when returning to Reunion.

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The information about "ILTIS" are provided by the European Opendata Portal: CORDIS opendata.

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