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Innate-Like T-Cells In Sepsis (ILTIS): Implications for Early Diagnosis and Rescue of Immune Suppression.

Total Cost €


EC-Contrib. €






 ILTIS project word cloud

Explore the words cloud of the ILTIS project. It provides you a very rough idea of what is the project "ILTIS" about.

delta    multidrug    medical    presentation    reunion    bench    earlier    clinical    me    collaborations    shaping    gamma    host    cell    fight    immunology    sepsis    create    pathogen    island    tackle    outbreaks    spread    monocytes    health    resistant    productive    immune    death    pathogens    keen    worldwide    neutrophils    aspiration    microbial    diagnosis    innate    join    ill    bed    severe    career    cardiff    functions    leptospirosis    benefit    relation    myself    community    eacute    internationally    shock    cytokine    threats    analysing    investigations    translational    bacteria    virus    antigen    soluble    union    pose    phagocytosis    teams    scientist    causative    acute    cellular    signatures    french    phenotype    hsdf    returning    public    renowned    university    molecular    septic    function    cells    vitro    communities    pave    release    acquired    prevent    cytokines    la    treatment    network    scientific    outcomes    infectious    research    diseases    viability    alarming    deciphering    am    activation    skills    mediated    pneumonia    expertise    link    disease    culture    chikungunya    considerable    types    infections    possibility   

Project "ILTIS" data sheet

The following table provides information about the project.


Organization address
address: NEWPORT ROAD 30-36
postcode: CF24 ODE

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 97˙727 €
 EC max contribution 97˙727 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CARDIFF UNIVERSITY UK (CARDIFF) coordinator 97˙727.00


 Project objective

Research on infectious diseases has high priority for the scientific and medical communities worldwide, to tackle the alarming spread of multidrug resistant bacteria and to fight and prevent virus outbreaks. On the French island of La Réunion, infections such as leptospirosis and chikungunya pose considerable threats for public health. My career aspiration is to establish myself as a clinical scientist in the field of immunology of microbial infections, especially in severe conditions such as septic shock and leptospirosis. I am also interested in deciphering the emerging role of host cell-derived factors (HSDF) in shaping the innate immune response. The immune response to pathogens and HSDF involves numerous cell types and soluble factors such as cytokines but remains ill-characterized. A better understanding of the cellular and molecular signatures in acute disease may pave the way to better and earlier diagnosis, targeted treatment and improved outcomes. The aim of the proposed study is to study the phenotype and function of innate immune cells during sepsis, with a particular focus on γδ T-cells, neutrophils and monocytes. This translational research involves bed to bench-side approaches (clinical investigations on septic shock during community-acquired pneumonia) and in vitro studies in cell culture, by analysing cell viability and activation as well as key cellular functions such as cytokine release, phagocytosis and antigen presentation in relation to the causative pathogen. I am keen to link this project with my previous studies on immune-mediated cell death during septic shock and on the early immune response to leptospirosis. The possibility to join the internationally renowned immunology teams at Cardiff University will be of great benefit to my research and will allow me to further my skills and expertise as well as create a network of productive collaborations for my future career when returning to Reunion.

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The information about "ILTIS" are provided by the European Opendata Portal: CORDIS opendata.

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