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Innate-Like T-Cells In Sepsis (ILTIS): Implications for Early Diagnosis and Rescue of Immune Suppression.

Total Cost €


EC-Contrib. €






 ILTIS project word cloud

Explore the words cloud of the ILTIS project. It provides you a very rough idea of what is the project "ILTIS" about.

resistant    cardiff    leptospirosis    shock    teams    eacute    me    investigations    relation    function    communities    diseases    outbreaks    earlier    reunion    causative    multidrug    delta    alarming    island    pneumonia    types    medical    network    cellular    culture    neutrophils    phenotype    shaping    severe    productive    tackle    career    phagocytosis    disease    vitro    pave    health    considerable    death    clinical    immunology    french    link    join    cytokine    scientist    mediated    create    possibility    pathogen    community    bacteria    bed    pathogens    antigen    public    aspiration    cell    acute    renowned    collaborations    prevent    fight    internationally    release    ill    la    outcomes    scientific    union    signatures    infections    cytokines    cells    innate    bench    sepsis    gamma    presentation    monocytes    benefit    deciphering    university    threats    myself    microbial    returning    skills    molecular    research    activation    host    septic    acquired    hsdf    spread    functions    treatment    soluble    worldwide    analysing    viability    am    virus    immune    keen    infectious    diagnosis    pose    expertise    chikungunya    translational   

Project "ILTIS" data sheet

The following table provides information about the project.


Organization address
address: NEWPORT ROAD 30-36
postcode: CF24 ODE

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 97˙727 €
 EC max contribution 97˙727 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CARDIFF UNIVERSITY UK (CARDIFF) coordinator 97˙727.00


 Project objective

Research on infectious diseases has high priority for the scientific and medical communities worldwide, to tackle the alarming spread of multidrug resistant bacteria and to fight and prevent virus outbreaks. On the French island of La Réunion, infections such as leptospirosis and chikungunya pose considerable threats for public health. My career aspiration is to establish myself as a clinical scientist in the field of immunology of microbial infections, especially in severe conditions such as septic shock and leptospirosis. I am also interested in deciphering the emerging role of host cell-derived factors (HSDF) in shaping the innate immune response. The immune response to pathogens and HSDF involves numerous cell types and soluble factors such as cytokines but remains ill-characterized. A better understanding of the cellular and molecular signatures in acute disease may pave the way to better and earlier diagnosis, targeted treatment and improved outcomes. The aim of the proposed study is to study the phenotype and function of innate immune cells during sepsis, with a particular focus on γδ T-cells, neutrophils and monocytes. This translational research involves bed to bench-side approaches (clinical investigations on septic shock during community-acquired pneumonia) and in vitro studies in cell culture, by analysing cell viability and activation as well as key cellular functions such as cytokine release, phagocytosis and antigen presentation in relation to the causative pathogen. I am keen to link this project with my previous studies on immune-mediated cell death during septic shock and on the early immune response to leptospirosis. The possibility to join the internationally renowned immunology teams at Cardiff University will be of great benefit to my research and will allow me to further my skills and expertise as well as create a network of productive collaborations for my future career when returning to Reunion.

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The information about "ILTIS" are provided by the European Opendata Portal: CORDIS opendata.

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