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ILTIS SIGNED

Innate-Like T-Cells In Sepsis (ILTIS): Implications for Early Diagnosis and Rescue of Immune Suppression.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ILTIS project word cloud

Explore the words cloud of the ILTIS project. It provides you a very rough idea of what is the project "ILTIS" about.

septic    immunology    molecular    acquired    pathogen    antigen    analysing    aspiration    delta    microbial    severe    ill    considerable    pose    presentation    research    island    reunion    treatment    eacute    cytokine    public    union    culture    sepsis    collaborations    community    productive    outcomes    bacteria    pneumonia    soluble    communities    function    activation    benefit    fight    teams    alarming    cell    gamma    skills    am    death    prevent    vitro    threats    shaping    neutrophils    release    returning    disease    earlier    multidrug    link    scientific    possibility    pathogens    deciphering    innate    viability    diseases    causative    infections    relation    bench    cardiff    create    university    cytokines    infectious    host    clinical    myself    monocytes    health    cells    keen    mediated    pave    virus    french    la    acute    renowned    tackle    shock    scientist    types    phenotype    immune    leptospirosis    chikungunya    outbreaks    translational    medical    internationally    bed    join    network    resistant    expertise    cellular    diagnosis    spread    me    worldwide    career    phagocytosis    hsdf    functions    signatures    investigations   

Project "ILTIS" data sheet

The following table provides information about the project.

Coordinator
CARDIFF UNIVERSITY 

Organization address
address: NEWPORT ROAD 30-36
city: CARDIFF
postcode: CF24 ODE
website: www.cardiff.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 97˙727 €
 EC max contribution 97˙727 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CARDIFF UNIVERSITY UK (CARDIFF) coordinator 97˙727.00

Map

 Project objective

Research on infectious diseases has high priority for the scientific and medical communities worldwide, to tackle the alarming spread of multidrug resistant bacteria and to fight and prevent virus outbreaks. On the French island of La Réunion, infections such as leptospirosis and chikungunya pose considerable threats for public health. My career aspiration is to establish myself as a clinical scientist in the field of immunology of microbial infections, especially in severe conditions such as septic shock and leptospirosis. I am also interested in deciphering the emerging role of host cell-derived factors (HSDF) in shaping the innate immune response. The immune response to pathogens and HSDF involves numerous cell types and soluble factors such as cytokines but remains ill-characterized. A better understanding of the cellular and molecular signatures in acute disease may pave the way to better and earlier diagnosis, targeted treatment and improved outcomes. The aim of the proposed study is to study the phenotype and function of innate immune cells during sepsis, with a particular focus on γδ T-cells, neutrophils and monocytes. This translational research involves bed to bench-side approaches (clinical investigations on septic shock during community-acquired pneumonia) and in vitro studies in cell culture, by analysing cell viability and activation as well as key cellular functions such as cytokine release, phagocytosis and antigen presentation in relation to the causative pathogen. I am keen to link this project with my previous studies on immune-mediated cell death during septic shock and on the early immune response to leptospirosis. The possibility to join the internationally renowned immunology teams at Cardiff University will be of great benefit to my research and will allow me to further my skills and expertise as well as create a network of productive collaborations for my future career when returning to Reunion.

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The information about "ILTIS" are provided by the European Opendata Portal: CORDIS opendata.

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