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HEpatocellular carcinoma GErmline MutatiONs ImpaCt (HEGEMONIC)

Total Cost €


EC-Contrib. €






 HEGEMONIC project word cloud

Explore the words cloud of the HEGEMONIC project. It provides you a very rough idea of what is the project "HEGEMONIC" about.

advantage    effect    group    conventional    individuals    recurrently    patients    nearly    exome    amount    combining    cancer    first    rare    sizes    replication    series    carcinogenesis    hypotheses    sequencing    ngs    validation    integrative    compare    regions    worldwide    limited    gwas    variants    cohorts    cells    signals    associations    hcc    hepatocellular    performed    uncovered    compiled    identification    small    normal    usually    analyze    environmental    350    carcinoma    candidate    genes    controls    never    susceptibility    host    phenotype    death    biological    coding    hegemonic    genome    uk10k    proportion    publicly    clinical    variation    landscape    extensive    mutated    thousands    generation    genomic    reflect    nevertheless    sources    generate    epi    germline    tumors    risk    genetic    linked    proposes    pharmaceutical    biomarkers    data    ultimately    aggregation    somatic    liver    association    genotype    confer    detection    suggesting    hypothesizes    despite    contributed    cancers    reproducibly    heritability    few    captured    wes   

Project "HEGEMONIC" data sheet

The following table provides information about the project.


There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2019-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE PARIS FR (PARIS) coordinator 173˙076.00


 Project objective

Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide. Although several environmental factors have been identified, many affected individuals never develop HCC, suggesting a genetic susceptibility. Candidate genes and genome-wide association studies (GWAS) have only uncovered a few variants reproducibly linked to HCC. GWAS design typically allows the detection of common variants that usually have small effect sizes. Even taken together, they explain a very limited proportion of the heritability. This could reflect the presence of rare variants that may confer very large effect sizes. These may be captured by next-generation sequencing (NGS). Whole exome sequencing (WES) of thousands of tumors has defined the somatic genetic landscape of the most common cancers. Using WES, the host group has strongly contributed to the identification of the major pathways recurrently mutated in HCC. Nevertheless, despite the large amount of NGS data generated by cancer genome projects, the analysis of rare germline variants (i.e. variation pre-existing in normal cells) is currently a neglected field, particularly in liver carcinogenesis. The HEGEMONIC project hypothesizes that rare variants in coding regions of the genome (exome) impact the risk of HCC. This project proposes an integrative approach combining (epi)genomic information generated by the host group and from publicly available sources. First, the applicant will compare WES data from a series of 350 patients with HCC to nearly 70,000 controls compiled by the Exome Aggregation and UK10K consortia. Then, validation of the top signals will be performed by conventional sequencing in three replication cohorts. Finally, the applicant will analyze genotype-phenotype associations, taking advantage of the extensive clinical data available. Ultimately, the HEGEMONIC project may generate new biological hypotheses in liver carcinogenesis and identify new biomarkers and pharmaceutical targets.

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The information about "HEGEMONIC" are provided by the European Opendata Portal: CORDIS opendata.

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