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GOLDENSENS

Intrinsically chiral gold nanoclusters as enantiodiscriminating sensors for methamphetamines.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "GOLDENSENS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE GENEVE 

Organization address
address: RUE DU GENERAL DUFOUR 24
city: GENEVE
postcode: 1211
website: www.unige.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.unige.ch/sciences/chifi/Buergi/start.html
 Total cost 175˙419 €
 EC max contribution 175˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE CH (GENEVE) coordinator 175˙419.00

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 Project objective

'The GOLDENSENS project aims at creating a new class of enantiodiscriminating sensors for methamphetamines based on intrinsically chiral Au38(SR)24 nanoclusters. These materials have unique optical properties which make them capable of conferring chirality to thiols protecting their surface, even when ligands themselves are achiral. The result of this chirality transfer is the formation of an asymmetric environment on the cluster surface which will be used for the enantiodiscrimination of D- and L-methamphetamines which can have distinct biological effects (The D-enantiomer is diffuse as psychotropic drug, whereas the L-enantiomer have been applied in medicine as in nasal decongestant). The first objective of GOLDENSENS will be the preparation of functional Au38 clusters. The protecting thiols of these novel clusters will bear specific chemical groups able to increase the enantioselective interactions with methamphetamines. The second objective will be the investigation of chiral properties of these gold nanoclusters by a combined chiroptical techniques and theoretical calculations. Ultimately, GOLDENSENS will investigate the enantiodiscriminating activity of prepared Au38 clusters towards methamphetamines, leading to the development of novel methods for enantiomeric separation. NMR-based techniques will quantify enantioselective interactions and 'absolute configuration modulation infrared spectroscopy' will clarify the mechanism of enantiodiscrimination by gold nanoclusters. Results and knowledge generated with GOLDENSENS will impact the understanding of chirality at the nanoscale, contributing to the growth of an emerging and frontier research field. The training provided by the project will help the experienced researcher to refine scientific and soft skills, ultimately acquiring all the abilities and competences necessary to start an independent academic career in nanotechnology.

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 Publications

year authors and title journal last update
List of publications.
2019 Laura Riccardi, Federico De Biasi, Marco De Vivo, Thomas Bürgi, Federico Rastrelli, Giovanni Salassa
Dynamic Origin of Chirality Transfer between Chiral Surface and Achiral Ligand in Au 38 Clusters
published pages: 7127-7134, ISSN: 1936-0851, DOI: 10.1021/acsnano.9b02552
ACS Nano 13/6 2019-11-22
2019 Giovanni Salassa, Alessio Terenzi
Metal Complexes of Oxadiazole Ligands: An Overview
published pages: 3483, ISSN: 1422-0067, DOI: 10.3390/ijms20143483
International Journal of Molecular Sciences 20/14 2019-11-22
2019 Marta Diez-Castellnou, Giovanni Salassa, Fabrizio Mancin, Paolo Scrimin
The Zn(II)-1,4,7-Trimethyl-1,4,7-Triazacyclononane Complex: A Monometallic Catalyst Active in Two Protonation States
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00469
Frontiers in Chemistry 7 2019-11-22

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The information about "GOLDENSENS" are provided by the European Opendata Portal: CORDIS opendata.

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