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Structure-activity relationships of an emerging family of fungal lytic polysaccharide monooxygenases

Total Cost €


EC-Contrib. €






 ARTFUL project word cloud

Explore the words cloud of the ARTFUL project. It provides you a very rough idea of what is the project "ARTFUL" about.

context    financial    chemicals    rising    lpmos    representative    solid    huge    host    polysaccharides    degrading    emissions    toolbox    structural    nevertheless    unsustainable    characterization    lignocellulosic    marseille    biology    efficiency    amounts    enzymology    first    artful    hydrocarbons    glycobiology    chemical    enzymes    shown    biochemistry    materials    fellow    reducing    functional    bioconversion    training    transfer    resource    catalytic    subsequent    france    maximise    organisation    reinforce    substantial    degradation    conversion    placing    source    century    center    cocktails    boost    led    environmental    fungal    sustainable    aix    omics    during    basis    fossil    lytic    collection    oxygenases    feedstock    predictive    arrangements    expertise    members    light    energy    shed    mono    co2    biomass    industrial    alternative    considerable    enlarging    cellulases    french    recalcitrance    improvement    tools    polysaccharide    penalties    secretomes    quality    physical    family    university    lpmo    experts    obstacle    screening    combined    societies    collaborations    enzymatic    recalcitrant    acquired    form    suited    thereby    bioinformatic    hosting   

Project "ARTFUL" data sheet

The following table provides information about the project.


Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 173˙076.00


 Project objective

During the past century, fossil-based hydrocarbons have been the main source of energy and chemicals, but in addition to be an unsustainable resource, they have led to important environmental concerns such as rising CO2 emissions. The great challenge for our societies is to develop alternative approaches for the sustainable production of energy and materials; the bioconversion of lignocellulosic biomass is one of them. Nevertheless, the physical and chemical recalcitrance of the biomass is the main obstacle to its cost-effective conversion as huge amounts of degrading enzymes are still required. Therefore, a significant improvement in enzymatic degradation is necessary, which involves enlarging the catalytic toolbox. By doing a large scale screening of the secretomes of a substantial fungal collection, the host organisation has shed light on the first member of a new family of lytic polysaccharide mono-oxygenases (LPMOs). LPMOs have been shown to boost the efficiency of cellulases industrial cocktails, thereby greatly reducing the financial and environmental penalties associated with the use of recalcitrant polysaccharides as a feedstock and, moreover, placing LPMOs at the center of considerable research interest. The objective of the ARTFUL project is the functional and structural characterization of the representative members of the new fungal LPMO family. The 6 years’ experience of the French fellow in the glycobiology field (biochemistry, enzymology, structural biology) combined with the expertise of Aix-Marseille University (France) in fungal omics form a solid basis that will be reinforce by the collaborations of experts. The quality of the hosting arrangements will maximise the training opportunities of the fellow and is suited for the two way transfer of knowledge. Acquired generated knowledge will provide a robust functional context to bioinformatic-based predictive biology as well as new enzymatic tools for subsequent industrial applications.


year authors and title journal last update
List of publications.
2018 Marie Couturier, Simon Ladevèze, Gerlind Sulzenbacher, Luisa Ciano, Mathieu Fanuel, Céline Moreau, Ana Villares, Bernard Cathala, Florence Chaspoul, Kristian E Frandsen, Aurore Labourel, Isabelle Herpoël-Gimbert, Sacha Grisel, Mireille Haon, Nicolas Lenfant, Hélène Rogniaux, David Ropartz, Gideon J Davies, Marie-Noëlle Rosso, Paul H Walton, Bernard Henrissat, Jean-Guy Berrin
Lytic xylan oxidases from wood-decay fungi unlock biomass degradation
published pages: 306-310, ISSN: 1552-4450, DOI: 10.1038/nchembio.2558
Nature Chemical Biology 14/3 2019-09-25
2018 Feng Zhang, George E. Anasontzis, Aurore Labourel, Charlotte Champion, Mireille Haon, Minna Kemppainen, Carine Commun, Aurélie Deveau, Alejandro Pardo, Claire Veneault-Fourrey, Annegret Kohler, Marie-Noëlle Rosso, Bernard Henrissat, Jean-Guy Berrin, Francis Martin
The ectomycorrhizal basidiomycete Laccaria bicolor releases a secreted β-1,4 endoglucanase that plays a key role in symbiosis development
published pages: 1309-1321, ISSN: 0028-646X, DOI: 10.1111/nph.15113
New Phytologist 220/4 2019-09-25

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