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iHealth-T2D SIGNED

Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes

Total Cost €

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EC-Contrib. €

0

Partnership

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 iHealth-T2D project word cloud

Explore the words cloud of the iHealth-T2D project. It provides you a very rough idea of what is the project "iHealth-T2D" about.

billion    members    waist    lifestyle    will    community    22    reverse    734    efficient    complete    risk    diabetes    gender    socio    weight    uk    modification    burden    healthy    prediabetes    intensive    sessions    india    screening    index    600    diet    diagnosis    central    family    thereby    power    asian    compare    clinical    secondary    poor    primary    group    80    asians    base    physician    world          intervention    physical    30    pakistan    health    prevention    equitable    utility    ge    preventing    100cm    treatment    120    session    women    glucose    worldwide    gt    locations    men    south    60    sri    endpoint    lanka    trial    effectiveness    endpoints    tolerance    predicted    strategy    24    evaluation    scalable    promotion    epidemic    coupled    cluster    hba1c    circumference    impaired    active    sites    usual    economic    onset    amongst    vs    followed    care    quarter    scalability    worker    obesity    limited    diabetic    population    randomised    t2d    annually   

Project "iHealth-T2D" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.ihealth-t2d.eu
 Total cost 3˙614˙083 €
 EC max contribution 3˙614˙083 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-HCO-2014
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 1˙386˙972.00
2    LONDON NORTH WEST HEALTHCARE NATIONAL HEALTH SERVICE TRUST UK (HARROW MIDDLESEX) participant 749˙537.00
3    DEVKI DEVI FOUNDATION SOCIETY IN (NEW DELHI) participant 247˙050.00
4    UNIVERSITY OF SURREY UK (GUILDFORD) participant 244˙233.00
5    SERVICES INSTITUTE OF MEDICAL SCIENCES PK (Lahore) participant 176˙900.00
6    OULUN YLIOPISTO FI (OULU) participant 166˙990.00
7    UNIVERSITY OF COLOMBO LK (COLOMBO WESTERN PROVINCE) participant 155˙550.00
8    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 146˙250.00
9    UNIVERSITY OF KELANIYA LK (KELANIYA) participant 121˙237.00
10    PUNJAB INSTITUTE OF CARDIOLOGY (PIC) LAHORE PK (LAHORE PUNJAB) participant 113˙612.00
11    INSTITUTE FOR HEALTH POLICY LK (COLOMBO) participant 105˙750.00
12    EALING HOSPITAL NHS TRUST UK (SOUTHALL) participant 0.00

Map

 Project objective

South Asians, who represent one-quarter of the world’s population, are at high risk of type-2 diabetes (T2D). Intensive lifestyle modification (healthy diet and physical activity) is effective at preventing T2D amongst South Asians with impaired glucose tolerance, but this approach is limited by high-cost, poor scalability and low impact on T2D burden. We will complete a cluster-randomised clinical trial at 120 locations across India, Pakistan, Sri Lanka and the UK. We will compare family-based intensive lifestyle modification (22 health promotion sessions from a community health worker, active group, N=60 sites) vs usual care (1 session, control group, N=60 sites) for prevention of T2D, amongst 3,600 non-diabetic South Asian men and women with central obesity (waist≥100cm) and/or prediabetes (HbA1c≥6.0%). Participants will be followed annually for 3 years. The primary endpoint will be new-onset T2D (physician diagnosis on treatment or HbA1c≥6.0%, predicted N~734 over 3 years). Secondary endpoints will include waist and weight in the index case and family members. Our study has 80% power to identify a reduction in T2D risk with family-based intervention vs usual care of: 30% in South Asians with central obesity; 24% in South Asians with prediabetes; and 24% overall. Health economic evaluation will determine cost-effectiveness of family based lifestyle modification for prevention of T2D amongst South Asians with central obesity and / or prediabetes. The impact of gender and socio-economic factors on clinical utility and cost-effectiveness will be investigated. Our results will determine whether screening by waist circumference and/or HbA1c, coupled with intervention by family-based lifestyle modification, is an efficient, effective and equitable strategy for prevention of T2D in South Asians. Our findings will thereby provide a robust evidence base for scalable community-wide approaches to reverse the epidemic of T2D amongst the >1.5 billion South Asians worldwide.

 Deliverables

List of deliverables.
Web Dissemination Websites, patent fillings, videos etc. 2020-03-11 10:38:00
Targeted Dissemination Other 2020-03-11 11:50:37
Final Reports on Outcomes Data Documents, reports 2020-03-11 11:50:39
Health Economic Analysis Documents, reports 2020-03-11 10:38:01
Report on Intervention Documents, reports 2019-09-02 09:23:07
Report on Recruitment Documents, reports 2019-09-02 09:23:07
Project Website Websites, patent fillings, videos etc. 2019-09-02 09:23:07

Take a look to the deliverables list in detail:  detailed list of iHealth-T2D deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Mirthe Muilwijk1*, Marie Loh2,3*, Sara Mahmood4, Saranya Palaniswamy3,5, Samreen Siddiqui6, Wnurinham Silva3, Gary S. Frost7, Heather M. Gage8, Marjo-Riitta Jarvelin3,5,9,10, Ravindra P. Rannan-Eliya11, Sajjad Ahmed12, Sujeet Jha6, Anuradhani Kasturiratne13, Prasad Katulanda14, Khadija I. Khawaja4, Jaspal S. Kooner15,16, Ananda R. Wickremasinghe13, Irene G.M. van Valkengoed1**, John C. Chambers2,3
The iHealth-T2D study: Statistical analysis plan for a cluster randomised controlled trial with intensive family-based lifestyle modification programme to reduce type 2 diabetes risk amongst South Asians
published pages: , ISSN: , DOI:
Trials 2020-03-05

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