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PHOTORNA SIGNED

Development of photoswitchable ligands for the reversible and selective assembly with RNA

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PHOTORNA project word cloud

Explore the words cloud of the PHOTORNA project. It provides you a very rough idea of what is the project "PHOTORNA" about.

photocontrollable    malfunction    photoswitchable    researcher    career    opportunity    irradiation    affinity    toward    inside    forms    nmr    dynamics    possibilities    therapy    gives    antiviral    indigo    time    relationships    photo    comprise    spectrometer    structures    mainly    selectivity    conjugates    hence    core    activated    pattern    antimicrobial    rna    possesses    exhibit    identification    character    association    tool    interdisciplinary    hemi    photoinduced    innovative    interactions    physiological    platform    modified    tested    drugs    function    reversible    easily    maturity    functional    special    ligands    systematic    structure    tuning    professional    bifunctional    varied    topical    substitution    ribonucleic    excellent    photoactive    photochromic    surprisingly    synthesized    generation    fulgide    acid    reversibly    spectroscopic    fine    anticipated    units    anticancer    binders    readily    binding    pharmacological    chosen    designed    course    derivatives    extensive    ligand    light    direct    responsive    library   

Project "PHOTORNA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET SIEGEN 

Organization address
address: ADOLF REICHWEIN STRASSE 2A
city: SIEGEN
postcode: 57076
website: www.uni-siegen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET SIEGEN DE (SIEGEN) coordinator 159˙460.00

Map

 Project objective

The proposed project aims at the development of novel functional ligands whose association with ribonucleic acid (RNA) is reversibly activated by light. As several RNA forms are essential key elements in physiological processes, the control of their function or malfunction by the reversible binding of photoswitchable ligands possesses a great potential as a tool in anticancer, antiviral and antimicrobial therapy. Surprisingly, this innovative approach towards a controlled reversible generation of RNA binders was mainly neglected in this highly topical research field. Hence, in this project photochromic hemi-indigo and fulgide derivatives are chosen as a platform for the design of photo-responsive RNA ligands, because i) they exhibit general features of RNA binders; ii) their structure can be reversibly modified by light, iii) the core structures are readily synthesized, and iii) the substitution pattern can be easily varied to enable fine-tuning of binding selectivity based on structure-activity relationships. In addition, conjugates that comprise two photoactive RNA-binding units will be obtained and studied because such bifunctional binders are expected to have very high affinity and selectivity toward RNA. An extensive library of derivatives will be synthesized and tested for their photocontrollable association with RNA. As a special method, real-time NMR-spectroscopic studies with direct irradiation of the sample inside a specifically designed spectrometer will be used to assess in detail the dynamics in the course of the photoinduced ligand–RNA interactions. Overall, it is anticipated that this systematic approach will enable the identification and development of lead structures for controllable RNA-targeting drugs with a great pharmacological potential. Moreover, the high interdisciplinary, innovative character of this challenging project gives the researcher an excellent opportunity to achieve professional maturity and open up best career possibilities.

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The information about "PHOTORNA" are provided by the European Opendata Portal: CORDIS opendata.

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