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PHOTORNA SIGNED

Development of photoswitchable ligands for the reversible and selective assembly with RNA

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PHOTORNA project word cloud

Explore the words cloud of the PHOTORNA project. It provides you a very rough idea of what is the project "PHOTORNA" about.

drugs    ribonucleic    mainly    photo    reversible    designed    platform    malfunction    modified    photoactive    photochromic    surprisingly    ligands    hence    antiviral    direct    indigo    inside    fine    dynamics    acid    structures    tested    opportunity    activated    anticipated    career    innovative    interdisciplinary    comprise    association    binding    core    derivatives    researcher    binders    possesses    irradiation    spectroscopic    light    units    exhibit    synthesized    special    pattern    identification    gives    antimicrobial    relationships    forms    possibilities    character    reversibly    fulgide    easily    topical    chosen    library    photoinduced    spectrometer    function    structure    hemi    tool    selectivity    generation    rna    interactions    extensive    tuning    excellent    varied    bifunctional    toward    course    photocontrollable    professional    affinity    nmr    pharmacological    ligand    readily    anticancer    conjugates    time    substitution    physiological    maturity    responsive    functional    systematic    therapy    photoswitchable   

Project "PHOTORNA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET SIEGEN 

Organization address
address: ADOLF REICHWEIN STRASSE 2A
city: SIEGEN
postcode: 57076
website: www.uni-siegen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2019-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET SIEGEN DE (SIEGEN) coordinator 159˙460.00

Map

 Project objective

The proposed project aims at the development of novel functional ligands whose association with ribonucleic acid (RNA) is reversibly activated by light. As several RNA forms are essential key elements in physiological processes, the control of their function or malfunction by the reversible binding of photoswitchable ligands possesses a great potential as a tool in anticancer, antiviral and antimicrobial therapy. Surprisingly, this innovative approach towards a controlled reversible generation of RNA binders was mainly neglected in this highly topical research field. Hence, in this project photochromic hemi-indigo and fulgide derivatives are chosen as a platform for the design of photo-responsive RNA ligands, because i) they exhibit general features of RNA binders; ii) their structure can be reversibly modified by light, iii) the core structures are readily synthesized, and iii) the substitution pattern can be easily varied to enable fine-tuning of binding selectivity based on structure-activity relationships. In addition, conjugates that comprise two photoactive RNA-binding units will be obtained and studied because such bifunctional binders are expected to have very high affinity and selectivity toward RNA. An extensive library of derivatives will be synthesized and tested for their photocontrollable association with RNA. As a special method, real-time NMR-spectroscopic studies with direct irradiation of the sample inside a specifically designed spectrometer will be used to assess in detail the dynamics in the course of the photoinduced ligand–RNA interactions. Overall, it is anticipated that this systematic approach will enable the identification and development of lead structures for controllable RNA-targeting drugs with a great pharmacological potential. Moreover, the high interdisciplinary, innovative character of this challenging project gives the researcher an excellent opportunity to achieve professional maturity and open up best career possibilities.

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The information about "PHOTORNA" are provided by the European Opendata Portal: CORDIS opendata.

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