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RAMP SIGNED

RAtionalising Membrane Protein crystallisation

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "RAMP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE GRENOBLE ALPES 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website https://ramp-itn.eu/
 Total cost 3˙199˙307 €
 EC max contribution 3˙199˙307 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE GRENOBLE ALPES FR (GRENOBLE) coordinator 525˙751.00
2    UNIVERSITE GRENOBLE ALPES FR (SAINT MARTIN D'HERES) coordinator 0.00
3    AARHUS UNIVERSITET DK (AARHUS C) participant 580˙163.00
4    UNIVERSITY OF LEEDS UK (LEEDS) participant 546˙575.00
5    NATIONAL UNIVERSITY OF IRELAND MAYNOOTH IE (Maynooth) participant 398˙511.00
6    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 273˙287.00
7    UNIVERSITY OF SURREY UK (GUILDFORD) participant 273˙287.00
8    EUROPEAN SPALLATION SOURCE ERIC SE (LUND) participant 263˙659.00
9    UNIVERSITAET HAMBURG DE (HAMBURG) participant 249˙216.00
10    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) participant 88˙853.00

Map

 Project objective

Membrane proteins form more than 85% of drug targets, but just 600 unique membrane protein crystal structures have been determined. A better understanding of how to crystallize membrane proteins reliably is therefore urgently required. The Innovative Training Network “RAtionalising Membrane Protein crystallisation” – RAMP will bring together cutting-edge physical chemistry methods for crystallisation condition control and phase diagram exploration, and the development of new lipids and screens in conjunction with industry with the most challenging biological problems. The network includes expert academic and industrial research groups in crystallisation theory, methods development, membrane protein crystallography, drug development and novel structural techniques like time-resolved and neutron crystallography. We will develop new, rational methods for crystallising membrane proteins, focusing particularly on transporters that are also interesting drug targets. The new robust crystallisation methods will also allow us to use emerging European research infrastructures like XFEL or ESS to gain insight into membrane protein function because the techniques will provide the necessary precise control of crystal size. A structured training programme organized by academia and industry together will equip the early stage researchers with the skills needed for a successful research career in the field of structural biology. Frequent secondments, research visits and meetings between early-career scientists ensure an efficient exchange of ideas and practical experiences between different groups leading to better integration of European research and innovations in structural biology. Supervision and mentoring by several senior scientists will give the researchers a strong scientific education and make them highly competitive in the work place of tomorrow. The work programme here will improve European competitiveness and advance graduate training.

 Deliverables

List of deliverables.
Appointment of a project manager Other 2020-02-12 10:37:46
Updated outreach plan Documents, reports 2020-02-12 10:37:46
Recruitment of all ESRs Other 2020-02-12 10:37:46

Take a look to the deliverables list in detail:  detailed list of RAMP deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Cristina Cecchetti, Euan Pyle, Bernadette Byrne
Transporter oligomerisation: roles in structure and function
published pages: 433-440, ISSN: 0300-5127, DOI: 10.1042/bst20180316
Biochemical Society Transactions 47/1 2020-02-12

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The information about "RAMP" are provided by the European Opendata Portal: CORDIS opendata.

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