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iChip SIGNED

Intestine-on-a-chip for investigating microbioal-epithelail interaction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 iChip project word cloud

Explore the words cloud of the iChip project. It provides you a very rough idea of what is the project "iChip" about.

mouse    guts    disease    outer    found    partly    culture    peristalsis    differently    stress    3d    mimic    villi    lines    fluidic    expanded    worldwide    colonize    generate    luminal    world    interactions    lumen    structures    insights    causality    tissues    natural    correlative    constitute    topologically    fought    first    epithelium    altogether    therapeutic    inflammation    cell    overgrowth    burden    physiology    mimics    pathogenic    organs    intestine    huge    models    occurrence    gut    microbial    reporting    time    cultured    microengineering    static    shortcomings    intestinal    inside    suppressed    epithelial    vivo    mechanisms    additionally    diseases    tumor    barrier    microenvironment    protects    react    mini    chip    cells    healthy    ways    surface    give    commensal    overcome    mechanic    primary    challenged    device    forms    animal    sheer    pathogens    microfluidics    off    difficult    bacteria    human    assayed    small    induces    occasionally    prevent    bacterial    2d    closely    crohn    tolerated    causing    model   

Project "iChip" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-02-12

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

The small intestine forms a barrier that protects us against the outer world. Here commensal bacteria are tolerated while pathogens are effectively fought off. Occasionally, however, pathogenic bacteria colonize the intestine causing different diseases, which constitute a huge burden worldwide. The ability to study interactions of pathogenic bacteria with the intestine will provide new insights into the disease mechanisms, and new therapeutic targets and ways to prevent disease occurrence. Current animal and 2D models based on tumor cell lines both have shortcomings as they react differently to pathogenic bacteria when compared to healthy human tissues.

Primary intestinal epithelial cells can now be cultured as intestinal mini-guts, 3D mini organs. This has partly overcome some of these shortcomings with mouse models and tumor cell lines. These mini-guts are, however, challenged topologically as the intestinal lumen is facing towards the inside of the structures. This makes it difficult to access the luminal surface and study microbial interactions with the epithelium. Furthermore, the static culture conditions do not mimic the in vivo conditions closely enough.

I will use microfluidics and microengineering to develop an intestine-on-a-chip device based on primary human intestinal epithelial cells expanded as mini-guts but assayed on mimics of the natural villi structures found in the small intestine. Additionally, the model will allow the fluidic (sheer stress) and mechanic (peristalsis) microenvironment to be closely controlled in order to generate in vivo-like conditions. This is important to study as e.g. Crohn’s disease, that induces suppressed peristalsis, is associated with intestinal inflammation and bacterial overgrowth.

Altogether, this intestine-on-a-chip device will go beyond state-of-the-art and for the first time give causality to the number of correlative studies reporting on how commensal and pathogenic gut bacteria affect the human physiology.

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The information about "ICHIP" are provided by the European Opendata Portal: CORDIS opendata.

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