Opendata, web and dolomites

iChip SIGNED

Intestine-on-a-chip for investigating microbioal-epithelail interaction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 iChip project word cloud

Explore the words cloud of the iChip project. It provides you a very rough idea of what is the project "iChip" about.

microfluidics    mechanisms    inflammation    crohn    burden    forms    expanded    healthy    outer    mimic    pathogens    microenvironment    model    pathogenic    partly    closely    surface    mini    natural    reporting    sheer    give    peristalsis    protects    world    huge    overcome    microbial    bacteria    correlative    tumor    ways    disease    overgrowth    microengineering    device    animal    assayed    prevent    shortcomings    suppressed    altogether    differently    mechanic    topologically    inside    generate    intestinal    occasionally    guts    epithelium    human    vivo    villi    difficult    therapeutic    cells    3d    found    first    structures    chip    tissues    primary    static    react    2d    insights    causing    occurrence    barrier    off    constitute    mouse    physiology    additionally    models    induces    commensal    bacterial    fought    luminal    causality    epithelial    challenged    cell    worldwide    small    fluidic    culture    tolerated    lumen    cultured    stress    intestine    colonize    lines    time    gut    interactions    diseases    organs    mimics   

Project "iChip" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-02-12

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

The small intestine forms a barrier that protects us against the outer world. Here commensal bacteria are tolerated while pathogens are effectively fought off. Occasionally, however, pathogenic bacteria colonize the intestine causing different diseases, which constitute a huge burden worldwide. The ability to study interactions of pathogenic bacteria with the intestine will provide new insights into the disease mechanisms, and new therapeutic targets and ways to prevent disease occurrence. Current animal and 2D models based on tumor cell lines both have shortcomings as they react differently to pathogenic bacteria when compared to healthy human tissues.

Primary intestinal epithelial cells can now be cultured as intestinal mini-guts, 3D mini organs. This has partly overcome some of these shortcomings with mouse models and tumor cell lines. These mini-guts are, however, challenged topologically as the intestinal lumen is facing towards the inside of the structures. This makes it difficult to access the luminal surface and study microbial interactions with the epithelium. Furthermore, the static culture conditions do not mimic the in vivo conditions closely enough.

I will use microfluidics and microengineering to develop an intestine-on-a-chip device based on primary human intestinal epithelial cells expanded as mini-guts but assayed on mimics of the natural villi structures found in the small intestine. Additionally, the model will allow the fluidic (sheer stress) and mechanic (peristalsis) microenvironment to be closely controlled in order to generate in vivo-like conditions. This is important to study as e.g. Crohn’s disease, that induces suppressed peristalsis, is associated with intestinal inflammation and bacterial overgrowth.

Altogether, this intestine-on-a-chip device will go beyond state-of-the-art and for the first time give causality to the number of correlative studies reporting on how commensal and pathogenic gut bacteria affect the human physiology.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ICHIP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ICHIP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

GrowthDevStability (2020)

Characterization of the developmental mechanisms ensuring a robust symmetrical growth in the bilateral model organism Drosophila melanogaster

Read More  

TCFLAND2SEA (2020)

Thawing Carbon From LAND to SEA: Microbial Degradation of Organic Matter and Response to Thawing Permafrost in the Northeast Siberian Land-Shelf System

Read More