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MelImmuneOrg SIGNED

Deciphering the tumor-immune-microenvironment profile and organization within the tumors of melanoma patients undergoing immunotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MelImmuneOrg project word cloud

Explore the words cloud of the MelImmuneOrg project. It provides you a very rough idea of what is the project "MelImmuneOrg" about.

progression    phenotypes    uncover    spatial    first    types    models    beam    immunotherapies    treatment    understand    inhibiting    immunotherapy    individual    expression    successful    time    meet    interplay    mass    profile    proteins    architecture    dr    specimens    imaging    cells    leader    structured    murine    mibi    visualize    hits    predictive    protein    cell    joining    microenvironments    independent    immune    therapy    skills    flight    sequencing    cancer    patients    suggest    preserving    melanoma    exome    influence    efficacy    competitiveness    heterogeneity    conjugated    researcher    functional    gain    multiplexed    tumor    lab    antibodies    oncology    metals    analyze    intact    intratumor    masters    keren    tof    immunosuppression    correlates    position    simultaneously    manipulation    tumors    dozens    undergoing    therapies    beneficial    ion    depends    significance    microenvironment    acquire    biology    scientists    organization    spectrometry    secondary    examine    discover    tissue    technique    genetic    ith   

Project "MelImmuneOrg" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 185˙464 €
 EC max contribution 185˙464 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 185˙464.00

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 Project objective

Cancer progression is a complex process that depends on the interplay between tumor cells, tumor microenvironment, and the immune system. Inhibiting immunosuppression is beneficial for cancer patients. Although these therapies are promising they are successful only in part of the patients. Tumors are composed of distinct cell types with different phenotypes, that influence the efficacy of immunotherapies. Therefore, in order to better understand tumor biology and response to treatment, it is necessary to profile protein expression while preserving spatial information. Multiplexed Ion Beam Imaging by Time of Flight (MIBI-TOF) is a method in which antibodies conjugated to metals are used to simultaneously visualize dozens of proteins in intact tissue specimens by secondary ion mass spectrometry. Here we suggest to uncover the immune profile and organization within the tumors of melanoma patients undergoing immunotherapy using MIBI-TOF. My first objective is to characterize the tumor-immune microenvironments to understand how these are structured across patients and discover predictive features of response to immunotherapies. My second objective is to analyze the intratumor heterogeneity (ITH) of melanoma patients by exome sequencing. I will examine whether there are genetic correlates between ITH, immune microenvironment and response to therapy. Finally, my third objective will be the manipulation of individual hits to test their functional significance in tumor-immune architecture in murine models. By joining Dr. Keren’s lab that masters the MIBI-TOF technology, I will acquire this state-of-the art technique, as well as develop lab management and organization skills, and I will meet leader scientists from the immune-oncology field. This proposal will promote my competitiveness to gain an independent researcher position.

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The information about "MELIMMUNEORG" are provided by the European Opendata Portal: CORDIS opendata.

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