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MelImmuneOrg SIGNED

Deciphering the tumor-immune-microenvironment profile and organization within the tumors of melanoma patients undergoing immunotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MelImmuneOrg project word cloud

Explore the words cloud of the MelImmuneOrg project. It provides you a very rough idea of what is the project "MelImmuneOrg" about.

mibi    skills    individual    metals    correlates    cells    imaging    functional    discover    ith    understand    specimens    tissue    masters    oncology    competitiveness    first    microenvironments    architecture    types    scientists    position    uncover    interplay    time    microenvironment    meet    proteins    protein    dr    sequencing    significance    suggest    patients    multiplexed    heterogeneity    leader    secondary    keren    ion    depends    spatial    cell    predictive    therapy    joining    researcher    cancer    beam    models    treatment    organization    expression    tumors    flight    exome    preserving    beneficial    lab    tumor    structured    dozens    successful    immunotherapy    acquire    analyze    therapies    efficacy    profile    spectrometry    inhibiting    immunotherapies    hits    technique    genetic    progression    biology    conjugated    melanoma    immune    tof    intratumor    undergoing    intact    murine    mass    independent    visualize    phenotypes    gain    examine    manipulation    simultaneously    influence    antibodies    immunosuppression   

Project "MelImmuneOrg" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 185˙464 €
 EC max contribution 185˙464 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 185˙464.00

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 Project objective

Cancer progression is a complex process that depends on the interplay between tumor cells, tumor microenvironment, and the immune system. Inhibiting immunosuppression is beneficial for cancer patients. Although these therapies are promising they are successful only in part of the patients. Tumors are composed of distinct cell types with different phenotypes, that influence the efficacy of immunotherapies. Therefore, in order to better understand tumor biology and response to treatment, it is necessary to profile protein expression while preserving spatial information. Multiplexed Ion Beam Imaging by Time of Flight (MIBI-TOF) is a method in which antibodies conjugated to metals are used to simultaneously visualize dozens of proteins in intact tissue specimens by secondary ion mass spectrometry. Here we suggest to uncover the immune profile and organization within the tumors of melanoma patients undergoing immunotherapy using MIBI-TOF. My first objective is to characterize the tumor-immune microenvironments to understand how these are structured across patients and discover predictive features of response to immunotherapies. My second objective is to analyze the intratumor heterogeneity (ITH) of melanoma patients by exome sequencing. I will examine whether there are genetic correlates between ITH, immune microenvironment and response to therapy. Finally, my third objective will be the manipulation of individual hits to test their functional significance in tumor-immune architecture in murine models. By joining Dr. Keren’s lab that masters the MIBI-TOF technology, I will acquire this state-of-the art technique, as well as develop lab management and organization skills, and I will meet leader scientists from the immune-oncology field. This proposal will promote my competitiveness to gain an independent researcher position.

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The information about "MELIMMUNEORG" are provided by the European Opendata Portal: CORDIS opendata.

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