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ESSEVOL

Adapting to Change: Experimental Evolution of Environmental Sensing Systems in Bacteria

Total Cost €

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EC-Contrib. €

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Partnership

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 ESSEVOL project word cloud

Explore the words cloud of the ESSEVOL project. It provides you a very rough idea of what is the project "ESSEVOL" about.

contaminants    combining    arbitrary    gap    sensing    reading    expertise    industrial    later    biotechnology    observing    altering    drive    drugs    monitoring    practical    threats    plays    move    evolve    bacterial    evolution    detection    group    genetic    antimicrobial    global    microbe    regulation    host    plan    obscure    power    light    experimental    natural    motility    origin    dna    public    good    select    shape    environmental    nature    away    things    toxic    puzzled    difficulties    scenarios    fill    techniques    resistance    setting    accordingly    understand    background    pressing    reporters    populations    coping    sense    sudden    bioremediation    drug    sequencing    usually    despite    tree    costly    health    living    decades    solution    life    changing    pathogens    largely    readily    couple    molecular    water    efforts    hypotheses    emergence    shed    ecological    theory    bacteria    time    outcomes    metals    cues    supplies    surroundings    organisms    methodology    behaviours   

Project "ESSEVOL" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://www.cbgp.upm.es/index.php/en/scientific-information/csbgp/alejandro-couce
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2019-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Background: Coping with ever-changing conditions is a problem common to most living things. One solution that organisms have come up with is the evolution of systems that allow them to sense and respond to their surroundings. Despite being usually complex and costly to maintain, sensing devices are widespread throughout the Tree of Life, which has puzzled researchers for years. Theory has identified a number of scenarios that promote the emergence of environmental sensing systems. Yet, most aspects of their origin and evolution remain obscure; largely due to the practical difficulties of observing these processes in real time. Here I propose to fill this gap by combining experimental evolution with the Host Group's expertise on the molecular regulation of bacterial behaviour. Methodology: The plan is to couple sudden changes in growth conditions with arbitrary environmental cues (e.g., toxic metals) to select for bacteria capable of reading these cues and altering their behaviour accordingly. I will target a well-studied behaviour: motility, which plays a key role in nature allowing bacteria to find good conditions and move away from threats. Using this setting, I will test decades-long hypotheses about the genetic and ecological factors that shape the emergence of novel sensing systems. Later, I will exploit the power of new DNA sequencing techniques to work out how genetic changes drive the new behaviours. Impact: This research will shed light on how readily novel sensing systems can evolve, thus contributing to efforts to understand pressing issues such as the emergence of multi-drug resistance pathogens or the response of natural populations to the current global change. Outcomes could also help in the design of novel antimicrobial drugs and microbe-based reporters with applications in bioremediation (e.g., detection of contaminants), biotechnology (e.g. monitoring of industrial processes) and in Public Health (e.g., detection of pathogens in water supplies).

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