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CATRATS

Catalytic Enantioselective Allene Cycloisomerisation Reactions for Alkaloid Total Synthesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 CATRATS project word cloud

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organic    material    subject    decades    route       resistant    plant    natural    host    training    contain    marie    computational    extremely    evaluation    vincristine    designed    cells    therapeutic    efficient    resistance    total    hexacyclic    science    individual    direct    ring    synthetic    arising    creation    beneficial    profile    enantioselective    azabicyclic    alkaloid    potently    alkaloids    multidrug    bioactivity    malaysian    manipulations    synthetically    complement    catalytic    core    synthesis    forge    career    last    toward    curie    leuconicines    sufficient    usually    augment    reduce    family    possess    involve    insufficient    transformations    incorporates    drain       reaction    biological    routes    calculations    fellowship    transferable    strychnos    members    extracts    intensive    source    hindered    molecules    stereocenters    leukemia    nevertheless    maingayi    prospects    accordingly    cycloisomerisation    combines    reverse    methodology    secure    leuconotis    investigation    quantities    skills    develops    fellow    desired    isolated   

Project "CATRATS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://dixon.chem.ox.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-12   to  2019-06-11

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

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 Project objective

A new catalytic enantioselective cycloisomerisation reaction for the direct creation of the azabicyclic core of strychnos alkaloids is proposed. Strychnos alkaloids have been the subject of intensive investigation over the last decades. Recently, leuconicines A and B, which are new members of the Strychnos alkaloid family, have been isolated from extracts of the Malaysian plant Leuconotis maingayi. Leuconicines possess significant bioactivity and they potently reverse multidrug resistance in vincristine-resistant leukemia cells. However, further studies into the biological profile of these natural products are hindered due to insufficient quantities being available from the natural source. In order to secure sufficient quantities and fully determine the therapeutic potential of the leuconicines, a new source of these target molecules is required. A new synthetic route which develops and incorporates ‘state-of-the-art’ methodologies to rapidly forge the extremely complex 6,5,5,6,6,6 hexacyclic ring system and 4 stereocenters, will provide the material. Nevertheless, the synthetic routes toward complex natural products are usually long, contain many individual steps and involve manipulations after each step. For these reasons, new, simple and synthetically efficient organic transformations which reduce the drain of resources are desired. This Fellowship project combines total synthesis, new catalytic enantioselective methodology development, computational calculations and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.

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The information about "CATRATS" are provided by the European Opendata Portal: CORDIS opendata.

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