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CATRATS

Catalytic Enantioselective Allene Cycloisomerisation Reactions for Alkaloid Total Synthesis

Total Cost €

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EC-Contrib. €

0

Partnership

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 CATRATS project word cloud

Explore the words cloud of the CATRATS project. It provides you a very rough idea of what is the project "CATRATS" about.

beneficial    maingayi       strychnos    multidrug    route    complement    host    involve    contain    designed    core    creation    therapeutic    direct    subject    cycloisomerisation    science    family    vincristine    quantities    catalytic    efficient    isolated    insufficient    hexacyclic    material    nevertheless    profile    hindered    last    fellowship    resistance    extracts    decades    marie    stereocenters    routes    biological    drain    forge    evaluation    intensive    synthetic    methodology    molecules    malaysian    secure    cells    training    organic    incorporates    toward    source    leukemia    augment    members    potently    leuconotis    calculations    usually    transferable    alkaloid    curie    reaction    natural    arising    accordingly    synthetically    sufficient    enantioselective    extremely    combines    fellow    desired    plant    bioactivity    alkaloids    prospects    azabicyclic    reverse    computational    reduce    leuconicines    investigation    transformations    career    ring    total       develops    possess    skills    resistant    synthesis    individual    manipulations   

Project "CATRATS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://dixon.chem.ox.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-12   to  2019-06-11

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

Map

 Project objective

A new catalytic enantioselective cycloisomerisation reaction for the direct creation of the azabicyclic core of strychnos alkaloids is proposed. Strychnos alkaloids have been the subject of intensive investigation over the last decades. Recently, leuconicines A and B, which are new members of the Strychnos alkaloid family, have been isolated from extracts of the Malaysian plant Leuconotis maingayi. Leuconicines possess significant bioactivity and they potently reverse multidrug resistance in vincristine-resistant leukemia cells. However, further studies into the biological profile of these natural products are hindered due to insufficient quantities being available from the natural source. In order to secure sufficient quantities and fully determine the therapeutic potential of the leuconicines, a new source of these target molecules is required. A new synthetic route which develops and incorporates ‘state-of-the-art’ methodologies to rapidly forge the extremely complex 6,5,5,6,6,6 hexacyclic ring system and 4 stereocenters, will provide the material. Nevertheless, the synthetic routes toward complex natural products are usually long, contain many individual steps and involve manipulations after each step. For these reasons, new, simple and synthetically efficient organic transformations which reduce the drain of resources are desired. This Fellowship project combines total synthesis, new catalytic enantioselective methodology development, computational calculations and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.

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The information about "CATRATS" are provided by the European Opendata Portal: CORDIS opendata.

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