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CATRATS

Catalytic Enantioselective Allene Cycloisomerisation Reactions for Alkaloid Total Synthesis

Total Cost €

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EC-Contrib. €

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Partnership

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 CATRATS project word cloud

Explore the words cloud of the CATRATS project. It provides you a very rough idea of what is the project "CATRATS" about.

bioactivity    azabicyclic    quantities    potently    last    malaysian       arising    source    vincristine    route    cycloisomerisation    alkaloid    skills    develops    possess    toward    subject    profile    organic    accordingly    reaction    investigation    extremely    synthetic    calculations    maingayi    sufficient    nevertheless    involve    individual    direct    fellowship    synthesis    alkaloids    extracts    multidrug    marie    insufficient    training    isolated    prospects    cells    host    creation    material    strychnos    incorporates    fellow    combines    methodology    resistant    ring    family    molecules    core    science    computational    desired    transferable       biological    usually    augment    leuconotis    beneficial    leukemia    synthetically    natural    decades    members    resistance    career    designed    reduce    contain    catalytic    forge    hexacyclic    manipulations    total    efficient    therapeutic    drain    secure    evaluation    complement    routes    reverse    curie    hindered    transformations    plant    leuconicines    stereocenters    intensive    enantioselective   

Project "CATRATS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://dixon.chem.ox.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-12   to  2019-06-11

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

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 Project objective

A new catalytic enantioselective cycloisomerisation reaction for the direct creation of the azabicyclic core of strychnos alkaloids is proposed. Strychnos alkaloids have been the subject of intensive investigation over the last decades. Recently, leuconicines A and B, which are new members of the Strychnos alkaloid family, have been isolated from extracts of the Malaysian plant Leuconotis maingayi. Leuconicines possess significant bioactivity and they potently reverse multidrug resistance in vincristine-resistant leukemia cells. However, further studies into the biological profile of these natural products are hindered due to insufficient quantities being available from the natural source. In order to secure sufficient quantities and fully determine the therapeutic potential of the leuconicines, a new source of these target molecules is required. A new synthetic route which develops and incorporates ‘state-of-the-art’ methodologies to rapidly forge the extremely complex 6,5,5,6,6,6 hexacyclic ring system and 4 stereocenters, will provide the material. Nevertheless, the synthetic routes toward complex natural products are usually long, contain many individual steps and involve manipulations after each step. For these reasons, new, simple and synthetically efficient organic transformations which reduce the drain of resources are desired. This Fellowship project combines total synthesis, new catalytic enantioselective methodology development, computational calculations and biological evaluation. It has been designed to augment and complement the research and transferable skills sets of the Marie Curie fellow and will greatly enhance his career prospects accordingly. Through the training and the research results arising, the Fellowship will be beneficial to the fellow, the host institution and European science.

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