Opendata, web and dolomites

IB4SD-TRISTAN SIGNED

Imaging Biomarkers (IBs) for Safer Drugs: Validation of Translational Imaging Methods in Drug Safety Assessment - Sofia ref.: 116106

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IB4SD-TRISTAN project word cloud

Explore the words cloud of the IB4SD-TRISTAN project. It provides you a very rough idea of what is the project "IB4SD-TRISTAN" about.

interstitial    follow    care    valid    withdraw    models    start    predict    biologicals    investigational    search    human    gadoxetate    specificity    biodistribution    injury    mr    translate    peptide    derive    mri    biomarker    validation    tags    fluorescence    compartmental    outstanding    pigs    transporter    underlying    developers    lung    regulatory    characterise    liability    volunteers    experts    humans    relationship    roadmap    forecasts    biologic    confidence    imaging    rat    physicians    drugs    129xe    deep    record    ibs    standard    1h    tools    trials    imaged    whatever    modeling    symptomatic    arrangements    toxicology    broad    internationally    standardise    commercially    dcemri    diild    patients    maldi    drug    animals    biologics    sensitivity    robustly    suspected    receiving    appropriate    chosen    exemplars    rheumatology    thoroughly    back    agents    centre    68ga    validate    building    healthcare    man    translating    cancer    multicentre    labeling    disease       18f    animal    pet    outcome    89zr    followed    ib    biology    believe    data    antibody    rats    clinical   

Project "IB4SD-TRISTAN" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL 

Organization address
address: Avenue E. Mounier 83
city: Brussels
postcode: 1200
website: www.eortc.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://www.imi-tristan.eu
 Total cost 22˙641˙050 €
 EC max contribution 12˙000˙000 € (53%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2015-07-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL BE (Brussels) coordinator 1˙241˙601.00
2    BIOXYDYN LIMITED UK (MANCHESTER) participant 1˙991˙627.00
3    UNIVERSITY OF LEEDS UK (LEEDS) participant 1˙367˙686.00
4    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 1˙361˙022.00
5    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 1˙310˙232.00
6    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 1˙099˙795.00
7    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) participant 994˙512.00
8    TRULY LABS AB SE (LUND) participant 644˙712.00
9    LUNDS UNIVERSITET SE (LUND) participant 609˙785.00
10    ANTAROS MEDICAL AB SE (MOLNDAL) participant 566˙025.00
11    CHALMERS TEKNISKA HOEGSKOLA AB SE (GOETEBORG) participant 563˙003.00
12    UNIVERSITE DIJON BOURGOGNE FR (DIJON CEDEX) participant 250˙000.00
13    ABBVIE DEUTSCHLAND GMBH & CO KG DE (WIESBADEN) participant 0.00
14    Bayer Pharma AG DE (Berlin) participant 0.00
15    BRUKER BIOSPIN MRI GMBH DE (ETTLINGEN) participant 0.00
16    GE HEALTHCARE LIMITED UK (LITTLE CHALFONT) participant 0.00
17    GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. UK (BRENTFORD) participant 0.00
18    MERCK SHARP & DOHME CORP US (WHITEHOUSE STATION NJ) participant 0.00
19    NOVO NORDISK A/S DK (BAGSVAERD) participant 0.00
20    PFIZER LIMITED UK (SANDWICH) participant 0.00
21    SANOFI-AVENTIS DEUTSCHLAND GMBH DE (FRANKFURT AM MAIN) participant 0.00

Map

 Project objective

1.Our consortium has broad, deep experience of drug development and imaging biomarker (IB) validation. We are internationally recognized experts in transporter biology, animal models of lung injury, toxicology, DCEMRI, compartmental modeling, 1H&129Xe lung MR, and labeling of biologicals with PET and fluorescence tags, together with physicians who care for relevant patients. We have an outstanding record of translating IBs: (a) into animals, (b) into man, (c) into tools which drug developers use with confidence in clinical trials of investigational agents, (d) into regulatory drug development and healthcare. We will develop and validate the required IBs and make them commercially available. 2.Building on our previous work with gadoxetate DCEMRI IBs we will develop and standardise, define sensitivity and specificity in rats, and show valid and comparable data multicentre in human volunteers and patients. 3.We believe the search for IBs of Drug Induced Interstitial Lung Disease (DIILD) should start in DIILD patients. Cancer and rheumatology patients receiving, in their standard care, drugs with DIILD liability, and whose physicians withdraw the drug due to suspected DIILD, will be imaged when symptomatic and followed up. From this we will derive IBs of DIILD which predict outcome. We will also develop IBs from 1H/129Xe MRI and PET to further characterise DIILD, and will back-translate and validate all these IBs in rat models. 4.To better assess biodistribution of biologics, we will thoroughly characterise two well-chosen exemplars in rats, pigs and humans: an antibody biologic and a peptide biologic. We will use 89Zr, 18F and 68Ga PET, fluorescence and MALDI imaging. 5.We will follow an imaging biomarker roadmap to establish (a) that the IBs can be deployed robustly in whatever centre they are needed, (b) the relationship of the IB to underlying biology, (c) how well the IB forecasts clinical outcome, and make appropriate arrangements for dissemination.

 Deliverables

List of deliverables.
Free-breathing 3D acquisition protocol for pre-clinical MRI Websites, patent fillings, videos etc. 2020-04-24 02:25:35
Manuscript on the progression of bleomycin induced inflammation and fibrosis in rats imaged by MRI/CT Documents, reports 2020-04-24 02:25:35
Manuscript on novel 89Zr chelates for protein labeling Documents, reports 2020-04-24 02:25:35
Manuscript for phantom imaging reproducibility Documents, reports 2020-04-24 02:25:35
Manuscript for reviews on ILD imaging in humans Documents, reports 2020-04-24 02:25:35
Free-breathing 3D acquisition protocol for clinical MRI Websites, patent fillings, videos etc. 2020-04-24 02:25:35
Gadoxetate imaging model software Websites, patent fillings, videos etc. 2020-04-24 02:25:35
Manuscript for a review on current 89Zr chelates for protein labeling Documents, reports 2020-04-24 02:25:34
Review 1 for liver transporter assessment by imaging Documents, reports 2020-04-24 02:25:34
Phantom QC for clinical MRI scanner stability over time Websites, patent fillings, videos etc. 2020-04-24 02:25:34
optimized data acquisition of 129 Xe MRI Websites, patent fillings, videos etc. 2020-04-24 02:25:34
Workplan for pre-clinical BSEP-probe evaluation Documents, reports 2020-04-24 02:25:34
Phantom QC for rat MRI scanner stability over time Websites, patent fillings, videos etc. 2020-04-24 02:25:34
Open-access website for validation SOP download Websites, patent fillings, videos etc. 2020-04-24 02:25:34

Take a look to the deliverables list in detail:  detailed list of IB4SD-TRISTAN deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Sandra Heskamp, René Raavé, Otto Boerman, Mark Rijpkema, Victor Goncalves, Franck Denat
89 Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89 Zr Radiochemistry
published pages: 2211-2223, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00325
Bioconjugate Chemistry 28/9 2020-04-24
2018 Sarah Skeoch, Nicholas Weatherley, Andrew Swift, Alexander Oldroyd, Christopher Johns, Conal Hayton, Alessandro Giollo, James Wild, John Waterton, Maya Buch, Kim Linton, Ian Bruce, Colm Leonard, Stephen Bianchi, Nazia Chaudhuri
Drug-Induced Interstitial Lung Disease: A Systematic Review
published pages: 356, ISSN: 2077-0383, DOI: 10.3390/jcm7100356
Journal of Clinical Medicine 7/10 2020-04-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IB4SD-TRISTAN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IB4SD-TRISTAN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.3.1.7.)

VITAL (2019)

Vaccines and Infectious Diseases in the Ageing PopuLation

Read More  

PD-MIND (2019)

Parkinson Disease with Mild cognition Impairment treated with Nicotinic agonist Drug

Read More  

NEURONET (2019)

Efficiently Networking European Neurodegeneration Research

Read More